INT4073

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Context Info
Confidence 0.81
First Reported 1976
Last Reported 2008
Negated 0
Speculated 3
Reported most in Abstract
Documents 28
Total Number 34
Disease Relevance 6.06
Pain Relevance 16.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Dbh) cytoplasm (Dbh)
Anatomy Link Frequency
vesicles 4
spinal cord 3
neurons 3
nerve 3
peptidergic neurons 2
Dbh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 81 100.00 Very High Very High Very High
Calcitonin gene-related peptide 81 100.00 Very High Very High Very High
Enkephalin 68 100.00 Very High Very High Very High
substance P 57 100.00 Very High Very High Very High
Catecholamine 22 100.00 Very High Very High Very High
Opioid 7 100.00 Very High Very High Very High
Serotonin 3 100.00 Very High Very High Very High
antagonist 4 99.60 Very High Very High Very High
Peripheral nervous system 4 99.60 Very High Very High Very High
Neuropeptide 28 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Spinal Cord Injury 12 97.80 Very High Very High Very High
Urological Neuroanatomy 7 93.88 High High
Injury 60 93.80 High High
Autonomic Dysreflexia 4 92.32 High High
Ataxia 4 90.76 High High
Spasticity 4 90.24 High High
Pain 20 89.36 High High
Diabetic Neuropathy 2 88.88 High High
Syndrome 4 88.84 High High
Increased Venous Pressure Under Development 11 88.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since noradrenergic neurons in the brain appear to inhibit ACTH secretion and dopamine-beta-hydroxylase (DBH) is found in noradrenergic neurons, the effect of variations in pituitary-adrenal activity on the activity of DBH in the brain stem, hypothalamus and hippocampus was determined.
Localization (secretion) of dopamine-beta-hydroxylase in neurons associated with dopamine and hippocampus
1) Confidence 0.81 Published 1976 Journal Neuroendocrinology Section Abstract Doc Link 967301 Disease Relevance 0.19 Pain Relevance 0.21
The catecholaminergic and peptidergic neurons in the area postrema and adjacent portion of the medial nucleus tractus solitarii (mNTS) were characterized by the immunocytochemical localization of the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) and two neuropeptides, substance P and (Leu5)-enkephalin.
Localization (localization) of DBH in peptidergic neurons associated with dopamine, catecholamine, neuropeptide, enkephalin and substance p
2) Confidence 0.79 Published 1981 Journal J. Comp. Neurol. Section Abstract Doc Link 6163796 Disease Relevance 0 Pain Relevance 0.41
The catecholaminergic and peptidergic neurons in the area postrema and adjacent portion of the medial nucleus tractus solitarii (mNTS) were characterized by the immunocytochemical localization of the catecholamine synthesizing enzymes tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) and two neuropeptides, substance P and (Leu5)-enkephalin.
Localization (localization) of dopamine-beta-hydroxylase in peptidergic neurons associated with dopamine, catecholamine, neuropeptide, enkephalin and substance p
3) Confidence 0.79 Published 1981 Journal J. Comp. Neurol. Section Abstract Doc Link 6163796 Disease Relevance 0 Pain Relevance 0.41
Immunohistologic localization of tyrosine hydroxylase (TOH), dopamine-beta-hydroxylase (DBH) and selected neuropeptides (vasoactive intestinal polypeptide, gastrin-releasing peptide (GRP)/bombesin, substance P, Leu-enkephalin, Met-enkephalin, dynorphin B, neuropeptide Y (NPY), somatostatin) was used to investigate the innervation of the small bowel in a rat model of diabetic autonomic neuropathy.
Spec (investigate) Localization (localization) of dopamine-beta-hydroxylase in bowel associated with dopamine, dynorphin, diabetic neuropathy, somatostatin, neuropeptide, enkephalin and substance p
4) Confidence 0.77 Published 1988 Journal Brain Res. Section Abstract Doc Link 2905198 Disease Relevance 0.23 Pain Relevance 0.48
Immunohistologic localization of tyrosine hydroxylase (TOH), dopamine-beta-hydroxylase (DBH) and selected neuropeptides (vasoactive intestinal polypeptide, gastrin-releasing peptide (GRP)/bombesin, substance P, Leu-enkephalin, Met-enkephalin, dynorphin B, neuropeptide Y (NPY), somatostatin) was used to investigate the innervation of the small bowel in a rat model of diabetic autonomic neuropathy.
Spec (investigate) Localization (localization) of DBH in bowel associated with dopamine, dynorphin, diabetic neuropathy, somatostatin, neuropeptide, enkephalin and substance p
5) Confidence 0.77 Published 1988 Journal Brain Res. Section Abstract Doc Link 2905198 Disease Relevance 0.23 Pain Relevance 0.48
Dopamine-beta-hydroxylase (DBH) and norepinephrine are both localized in noradrenergic storage vesicles.
Localization (localized) of Dopamine-beta-hydroxylase in vesicles associated with dopamine
6) Confidence 0.76 Published 1980 Journal Brain Res. Section Abstract Doc Link 7363084 Disease Relevance 0 Pain Relevance 0.13
Dopamine-beta-hydroxylase (DBH) and norepinephrine are both localized in noradrenergic storage vesicles.
Localization (localized) of DBH in vesicles associated with dopamine
7) Confidence 0.76 Published 1980 Journal Brain Res. Section Abstract Doc Link 7363084 Disease Relevance 0 Pain Relevance 0.13
Since noradrenergic neurons in the brain appear to inhibit ACTH secretion and dopamine-beta-hydroxylase (DBH) is found in noradrenergic neurons, the effect of variations in pituitary-adrenal activity on the activity of DBH in the brain stem, hypothalamus and hippocampus was determined.
Localization (secretion) of DBH in neurons associated with dopamine and hippocampus
8) Confidence 0.75 Published 1976 Journal Neuroendocrinology Section Abstract Doc Link 967301 Disease Relevance 0.22 Pain Relevance 0.22
Since noradrenergic neurons in the brain appear to inhibit ACTH secretion and dopamine-beta-hydroxylase (DBH) is found in noradrenergic neurons, the effect of variations in pituitary-adrenal activity on the activity of DBH in the brain stem, hypothalamus and hippocampus was determined.
Localization (secretion) of DBH in neurons associated with dopamine and hippocampus
9) Confidence 0.75 Published 1976 Journal Neuroendocrinology Section Abstract Doc Link 967301 Disease Relevance 0.20 Pain Relevance 0.21
Their staining properties appear to reflect mainly noradrenaline and small molecules that can leak out from the vesicles in parallel with the transmitter. (6) Dopamine beta-hydroxylase and opioid peptides secreted from the noradrenergic terminals most probably originate from the large vesicles. (7) The hypothesis that only the large dense-cored vesicles contain and secrete dopamine beta-hydroxylase and opioids can help to explain the species differences in the concentrations of these substances observed in certain tissues.
Localization (secrete) of dopamine beta-hydroxylase in vesicles associated with dopamine, noradrenaline and opioid
10) Confidence 0.72 Published 1983 Journal Neuroscience Section Abstract Doc Link 6633860 Disease Relevance 0 Pain Relevance 0.41
Antibodies directed towards calcitonin gene-related peptide (CGRP) and dopamine beta-hydroxylase (DBH) were used for the staining of peptidergic and sympathetic fibers, respectively.
Localization (directed) of dopamine beta-hydroxylase in sympathetic associated with dopamine and calcitonin gene-related peptide
11) Confidence 0.71 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2637239 Disease Relevance 0.70 Pain Relevance 0.72
Antibodies directed towards calcitonin gene-related peptide (CGRP) and dopamine beta-hydroxylase (DBH) were used for the staining of peptidergic and sympathetic fibers, respectively.
Localization (directed) of DBH in sympathetic associated with dopamine and calcitonin gene-related peptide
12) Confidence 0.71 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2637239 Disease Relevance 0.70 Pain Relevance 0.72
In the present study we evaluated the distribution of biochemically specific cells and fibers within the AVPv and adjacent regions by using an indirect immunohistochemical method with antisera to serotonin (5-HT), dopamine beta-hydroxylase (DBH), tyrosine hydroxylase (TH), neuropeptide Y (NPY), cholecystokinin-8 (CCK), vasoactive intestinal polypeptide (VIP), substance P (SP), neurotensin (NT), corticotropin-releasing factor (CRF), luteotropin-releasing hormone (LRH), somatostatin (SS), thyrotropin-releasing hormone (TRH), oxytocin (OXY), vasopressin (VAS), adrenocorticotropic hormone (ACTH1-24), alpha-melanocyte-stimulating hormone (alpha-MSH), leucine-enkephalin (L-ENK), and calcitonin gene-related peptide (CGRP).
Localization (using) of DBH in AVPv associated with dopamine, somatostatin, enkephalin, calcitonin gene-related peptide, neuropeptide, serotonin, cholecystokinin and substance p
13) Confidence 0.67 Published 1987 Journal Brain Res. Section Abstract Doc Link 2880634 Disease Relevance 0 Pain Relevance 0.62
In the present study we evaluated the distribution of biochemically specific cells and fibers within the AVPv and adjacent regions by using an indirect immunohistochemical method with antisera to serotonin (5-HT), dopamine beta-hydroxylase (DBH), tyrosine hydroxylase (TH), neuropeptide Y (NPY), cholecystokinin-8 (CCK), vasoactive intestinal polypeptide (VIP), substance P (SP), neurotensin (NT), corticotropin-releasing factor (CRF), luteotropin-releasing hormone (LRH), somatostatin (SS), thyrotropin-releasing hormone (TRH), oxytocin (OXY), vasopressin (VAS), adrenocorticotropic hormone (ACTH1-24), alpha-melanocyte-stimulating hormone (alpha-MSH), leucine-enkephalin (L-ENK), and calcitonin gene-related peptide (CGRP).
Localization (using) of dopamine beta-hydroxylase in AVPv associated with dopamine, somatostatin, enkephalin, calcitonin gene-related peptide, neuropeptide, serotonin, cholecystokinin and substance p
14) Confidence 0.67 Published 1987 Journal Brain Res. Section Abstract Doc Link 2880634 Disease Relevance 0 Pain Relevance 0.62
Their staining properties appear to reflect mainly noradrenaline and small molecules that can leak out from the vesicles in parallel with the transmitter. (6) Dopamine beta-hydroxylase and opioid peptides secreted from the noradrenergic terminals most probably originate from the large vesicles. (7) The hypothesis that only the large dense-cored vesicles contain and secrete dopamine beta-hydroxylase and opioids can help to explain the species differences in the concentrations of these substances observed in certain tissues.
Localization (secreted) of Dopamine beta-hydroxylase in vesicles associated with dopamine, noradrenaline and opioid
15) Confidence 0.67 Published 1983 Journal Neuroscience Section Abstract Doc Link 6633860 Disease Relevance 0 Pain Relevance 0.42
The catecholamine synthesizing enzymes TH and DBH, found jointly only in noradrenergic and adrenergic neurons, were localized in cells having a similar morphology and topographical distribution.
Localization (localized) of DBH in adrenergic neurons associated with catecholamine
16) Confidence 0.65 Published 1981 Journal J. Comp. Neurol. Section Abstract Doc Link 6163796 Disease Relevance 0.06 Pain Relevance 0.44
The immunocytochemical localizations of substance P, neurotensin, enkephalin and the catecholamine-synthesizing enzymes tyrosine hydroxylase and dopamine-beta-hydroxylase were examined in the rat parabrachial region.
Spec (examined) Localization (localizations) of dopamine-beta-hydroxylase associated with dopamine, catecholamine, enkephalin, parabrachial and substance p
17) Confidence 0.65 Published 1984 Journal J. Comp. Neurol. Section Abstract Doc Link 6205025 Disease Relevance 0 Pain Relevance 0.56
In the upper dermis, the DBH-IR fibers were rarely located around blood vessels, but were often observed wrapping around calcitonin gene-related peptide (CGRP)-IR fibers (Figure 2C, arrows).
Localization (located) of DBH-IR in blood vessels associated with calcitonin gene-related peptide
18) Confidence 0.62 Published 2008 Journal Mol Pain Section Body Doc Link PMC2637239 Disease Relevance 0.35 Pain Relevance 0.25
All the material used for quantification was single-labeled for either CGRP or DBH.
Localization (labeled) of DBH associated with calcitonin gene-related peptide
19) Confidence 0.62 Published 2008 Journal Mol Pain Section Body Doc Link PMC2637239 Disease Relevance 0 Pain Relevance 0.17
Co-localization of substance P and dopamine beta-hydroxylase with growth-associated protein-43 is lost caudal to a spinal cord transection.
Localization (Co-localization) of dopamine beta-hydroxylase in spinal cord associated with dopamine, spinal cord and substance p
20) Confidence 0.61 Published 1999 Journal Neuroscience Section Title Doc Link 10336136 Disease Relevance 0.99 Pain Relevance 0.62

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