INT40742

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Context Info
Confidence 0.37
First Reported 1981
Last Reported 1994
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pomc, Gh1) signal transduction (Pomc, Gh1) extracellular region (Pomc, Gh1)
mitochondrion (Gh1) cell-cell signaling (Pomc) cytoplasm (Pomc)
Anatomy Link Frequency
brain 2
Pomc (Rattus norvegicus)
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 2 100.00 Very High Very High Very High
opiate 5 98.98 Very High Very High Very High
monoamine 1 98.64 Very High Very High Very High
antagonist 6 93.12 High High
Morphine 1 76.64 Quite High
Opioid 3 75.00 Quite High
narcan 1 53.68 Quite High
Dopamine 2 35.92 Quite Low
Clonidine 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of synthetic enkephalin analog (KF 33-824) and beta-endorphin on growth hormone (GH) secretion and their interaction with brain monoamines were investigated in unanesthetized male rats.
beta-endorphin Spec (investigated) Regulation (effects) of Localization (secretion) of GH in brain associated with enkephalin and monoamine
1) Confidence 0.37 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6117022 Disease Relevance 0 Pain Relevance 0.32
These results provide evidence that all three opiate receptor subtypes are involved in the stimulatory effect of beta-endorphin on GH release.
beta-endorphin Regulation (effect) of Localization (release) of GH associated with opiate
2) Confidence 0.16 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 8090284 Disease Relevance 0 Pain Relevance 0.54

General Comments

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