INT40748

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Context Info
Confidence 0.56
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 10
Disease Relevance 8.33
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mif) cell proliferation (Mif) extracellular space (Mif)
extracellular region (Mif) nucleus (Mif) cytoplasm (Mif)
Anatomy Link Frequency
macrophage 1
liver 1
Mif (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 4 99.84 Very High Very High Very High
dexamethasone 8 99.30 Very High Very High Very High
Opioid 2 97.16 Very High Very High Very High
Neuritis 6 97.08 Very High Very High Very High
Enkephalin 2 95.68 Very High Very High Very High
Inflammatory mediators 15 92.08 High High
Inflammation 139 87.28 High High
narcan 1 86.80 High High
cytokine 65 85.44 High High
Morphine 4 85.00 Quite High
Disease Link Frequency Relevance Heat
Glioma 5 99.74 Very High Very High Very High
Cancer 210 99.36 Very High Very High Very High
Sepsis 99 99.36 Very High Very High Very High
Syndrome 6 98.52 Very High Very High Very High
Metastasis 15 98.22 Very High Very High Very High
Experimental Autoimmune Neuritis 6 97.08 Very High Very High Very High
Colon Cancer 20 96.08 Very High Very High Very High
Hypoxia 40 95.52 Very High Very High Very High
Skin Cancer 5 93.76 High High
Malignant Neoplastic Disease 10 92.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The findings show that MIF-I weakly and selectively inhibits mu-type opiate receptors which suggests that MIF-I could be an endogenous inhibitor of opiate receptors.
Negative_regulation (inhibitor) of MIF-I associated with opiate
1) Confidence 0.56 Published 1980 Journal Peptides Section Abstract Doc Link 6117839 Disease Relevance 0.08 Pain Relevance 0.84
Transformation induced by Ras was restored upon deletion of p53.25,26

MIF receptor signalling and tumour pathogenesis

Negative_regulation (deletion) of MIF receptor associated with cancer
2) Confidence 0.41 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.44 Pain Relevance 0.12
Small molecular weight inhibitors of MIF tautomerase activity have also been used to dissect out the importance of this unique activity in cancer pathogenesis.
Negative_regulation (inhibitors) of MIF tautomerase associated with cancer
3) Confidence 0.41 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 0.94 Pain Relevance 0.06
ISO-1 is one such inhibitor designed to fit into the catalytic site of MIF.60 Using colorectal cancer as a model where serum concentration of MIF have been shown to correlate with increased risk of metastasis to the liver, in vivo treatment of colon carcinoma-bearing mice with ISO-1 results in decreased tumour volume, reduced angiogenesis and less liver metastasis.61 ISO-1 has also been shown to restore dexamethasone sensitivity in glioma cells which inhibits MIF-induced promotion of migration and invasion of the cells via MAP kinases.
Negative_regulation (inhibits) of MIF-induced in liver associated with cancer, colon cancer, dexamethasone, glioma and metastasis
4) Confidence 0.41 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.08 Pain Relevance 0.08
Therefore, to evaluate the role of macrophage migration inhibitory factor (MIF) in Guillain-Barré syndrome (GBS) and experimental allergic neuritis (EAN), we determined MIF circulating levels in a series of patients with GBS and healthy subjects with ELISA and evaluated the effect of two specific inhibitors of MIF, a neutralizing monoclonal antibody or a chemical inhibitor ISO1 on the course of murine EAN.
Negative_regulation (inhibitors) of MIF in macrophage associated with experimental autoimmune neuritis, syndrome and neuritis
5) Confidence 0.37 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 16171874 Disease Relevance 1.36 Pain Relevance 0.66
and, more importantly, loss of MIF results in inefficient HIF-1?
Negative_regulation (loss) of MIF
6) Confidence 0.36 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 1.33 Pain Relevance 0
While binding of MIF to CD74 and JAB1 was not significantly reduced, the mutation eliminated MIF enzymatic activity and intriguingly impaired specific MIF biological activity.
Negative_regulation (impaired) of MIF
7) Confidence 0.36 Published 2010 Journal QJM: An International Journal of Medicine Section Body Doc Link PMC2955282 Disease Relevance 0.78 Pain Relevance 0.04
For instance, blockade of MIF with
         neutralising antibodies as late as 8 h after onset of experimental sepsis
         improved survival in mice (Ref. 22). 
Negative_regulation (blockade) of MIF associated with sepsis
8) Confidence 0.16 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 1.18 Pain Relevance 0.21
Incubation of marrow cells in liquid culture and removal of Tyr-MIF prior to quantitating progenitor cell proliferation demonstrated that opioid-induced inhibition was reversible.
Negative_regulation (removal) of Tyr-MIF associated with opioid
9) Confidence 0.13 Published 2002 Journal Int. Immunopharmacol. Section Abstract Doc Link 12013510 Disease Relevance 0 Pain Relevance 0.46
RESULTS: A significant decrease in MIF occurred at all times after the EE.
Negative_regulation (decrease) of MIF
10) Confidence 0.05 Published 2002 Journal Med Sci Sports Exerc Section Body Doc Link 11880808 Disease Relevance 0.16 Pain Relevance 0

General Comments

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