INT4075

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Context Info
Confidence 0.68
First Reported 1976
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 24
Total Number 25
Disease Relevance 19.99
Pain Relevance 4.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gast) extracellular region (Gast)
Anatomy Link Frequency
blood 4
plasma 2
margin 2
neurons 2
proximal 2
Gast (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 13 100.00 Very High Very High Very High
Cholecystokinin 32 99.90 Very High Very High Very High
Chronic pancreatitis 17 99.36 Very High Very High Very High
Nicotine 68 97.88 Very High Very High Very High
calcitonin gene related peptide 1 97.60 Very High Very High Very High
Bile 3 96.04 Very High Very High Very High
alcohol 9 95.44 Very High Very High Very High
Inflammation 9 94.88 High High
qutenza 8 94.16 High High
cytokine 2 93.84 High High
Disease Link Frequency Relevance Heat
Infection 191 100.00 Very High Very High Very High
Disease 153 100.00 Very High Very High Very High
Gastritis 6 99.98 Very High Very High Very High
Pancreatitis 44 99.36 Very High Very High Very High
Alcoholic Pancreatitis 2 99.36 Very High Very High Very High
Streptococcal Infections 12 99.08 Very High Very High Very High
Ulcers 39 99.02 Very High Very High Very High
Atrophic Gastritis 5 98.84 Very High Very High Very High
Duodenal Ulcer 3 98.04 Very High Very High Very High
Hyperplasia 1 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicate that diseases with increased synthesis of gastrin are accompanied by an abnormal degree of sulfation.
Positive_regulation (increased) of Gene_expression (synthesis) of gastrin associated with disease
1) Confidence 0.68 Published 1983 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 6669933 Disease Relevance 0.98 Pain Relevance 0.07
Chronic alcoholism, however, does not appear to be the only factor responsible for the increased plasma gastrin levels in these patients.


Positive_regulation (increased) of Gene_expression (levels) of gastrin in plasma
2) Confidence 0.67 Published 2001 Journal Ann Saudi Med Section Body Doc Link 17264580 Disease Relevance 0.14 Pain Relevance 0
After a single dose of 100 mg/kg in fasting rats, ebrotidine increased significantly serum gastrin levels within 2 and 5 h after administration, but 8 h after administration serum gastrin levels returned to normal values.
Positive_regulation (increased) of Gene_expression (levels) of gastrin
3) Confidence 0.50 Published 1997 Journal Arzneimittelforschung Section Abstract Doc Link 9205740 Disease Relevance 0 Pain Relevance 0.15
The increase in somatostatin secretion caused by DMPP and field stimulation, as well as the resistance of gastrin and somatostatin secretion to atropine, was consistent with preferential activation of noncholinergic neurons at the stimulatory modalities used.
Positive_regulation (increase) of Gene_expression (resistance) of gastrin in neurons associated with somatostatin
4) Confidence 0.50 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 2892415 Disease Relevance 0 Pain Relevance 0.47
Eight patients with chronic duodenal ulcer and referred for proximal gastric vagotomy were studied. 24-hour intragastric acidity and plasma gastrin levels were investigated in the same patients on three consecutive occasions: preentry without any treatment; after 4 weeks of administration of 20 mg of omeprazole daily, and 4-6 months after proximal gastric vagotomy.
Spec (investigated) Positive_regulation (investigated) of Gene_expression (levels) of gastrin in proximal associated with duodenal ulcer
5) Confidence 0.49 Published 1990 Journal Gastroenterology Section Abstract Doc Link 2227275 Disease Relevance 0.36 Pain Relevance 0.09
Post-stimulation gastrin concentration were higher in chronic pancreatitis patients or in normal alcoholics (peak post-stimulation value: 74 +/- 41 and 74 +/- 43 pg/ml respectively) than in cirrhotics or non alcoholic controls (45 +/- 26 and 41 +/- 15 pg/ml respectively) (m +/- SD).
Positive_regulation (Post-stimulation) of Gene_expression (concentration) of gastrin associated with chronic pancreatitis
6) Confidence 0.49 Published 1980 Journal Horm. Metab. Res. Section Abstract Doc Link 7409735 Disease Relevance 0.44 Pain Relevance 0.15
Sodium taurocholate and deoxycholate (> 2.5 mM) significantly increased the serum levels of gastrin.
Positive_regulation (increased) of Gene_expression (levels) of gastrin
7) Confidence 0.47 Published 1995 Journal J. Gastroenterol. Section Abstract Doc Link 7719401 Disease Relevance 0 Pain Relevance 0.60
In contrast, ranitidine increased serum gastrin levels significantly and in a dose-dependent manner with respect to control group.
Positive_regulation (increased) of Gene_expression (levels) of gastrin
8) Confidence 0.46 Published 1997 Journal Arzneimittelforschung Section Abstract Doc Link 9205740 Disease Relevance 0 Pain Relevance 0.24
We conclude that (1) exogenous melatonin and that derived from its precursor, L-tryptophan, accelerate ulcer healing probably via interaction with MT2 receptors; (2) this ulcer healing action is caused by an enhancement by melatonin of the microcirculation at the ulcer margin possibly mediated by COX-derived PG and NO because of overexpression of iNOS and (3) gastrin, which exhibits trophic activity in the gastric mucosa and calcitonin gene related peptide (CGRP), released from sensory nerves, may also contribute to the ulcer healing action of melatonin.
Positive_regulation (overexpression) of Gene_expression (overexpression) of gastrin in margin associated with calcitonin gene related peptide and ulcers
9) Confidence 0.46 Published 2002 Journal J. Pineal Res. Section Abstract Doc Link 12074098 Disease Relevance 1.16 Pain Relevance 0.11
A significant increase in serum gastrin levels was observed in patients with chronic pancreatitis compared with controls, both in basal conditions and following food stimulation.
Positive_regulation (increase) of Gene_expression (levels) of gastrin associated with chronic pancreatitis
10) Confidence 0.46 Published 1976 Journal Minerva Med. Section Abstract Doc Link 967355 Disease Relevance 0.27 Pain Relevance 0.10
As seen from various publications, the adjuvant use of transcranial electrostimulation (TCE) stimulates ulcer healing (the defect healed 2-3.5 times faster), promotes normalization of serum gastrin levels both in its high and low values produces analgetic, membrane stabilizing, reparative, sedative, immunomodulating and antitumor effects.
Positive_regulation (promotes) of Gene_expression (levels) of gastrin associated with ulcers
11) Confidence 0.46 Published 1994 Journal Vopr Kurortol Fizioter Lech Fiz Kult Section Abstract Doc Link 7762203 Disease Relevance 0.10 Pain Relevance 0.07
Urinary 5-hydroxyindoleacetic acid (5-HIAA) and serum gastrin levels were elevated in 17% and 50% of those tested, respectively.
Positive_regulation (elevated) of Gene_expression (levels) of gastrin
12) Confidence 0.46 Published 1994 Journal World J Surg Section Abstract Doc Link 7725731 Disease Relevance 1.65 Pain Relevance 0.08
PPIs have been shown to increase serum gastrin levels.
Positive_regulation (increase) of Gene_expression (levels) of gastrin
13) Confidence 0.41 Published 2008 Journal Rev Prat Section Abstract Doc Link 18924330 Disease Relevance 1.04 Pain Relevance 0.09
Suppression of endogenous gastrin restored responsiveness to exogenous gastrin.
Positive_regulation (Suppression) of Gene_expression (Suppression) of gastrin
14) Confidence 0.39 Published 1988 Journal Surgery Section Abstract Doc Link 2903562 Disease Relevance 0.70 Pain Relevance 0.11
There were moderate increases in fasting serum gastrin levels with both treatments at 4 and 8 weeks.
Positive_regulation (increases) of Gene_expression (levels) of gastrin
15) Confidence 0.25 Published 1995 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 7766739 Disease Relevance 0 Pain Relevance 0
Increased serum gastrin levels confirm the diagnosis biochemically.
Positive_regulation (Increased) of Gene_expression (levels) of gastrin
16) Confidence 0.22 Published 2007 Journal Wien. Klin. Wochenschr. Section Abstract Doc Link 17985090 Disease Relevance 1.38 Pain Relevance 0.26
However, CCK and gastrin levels in the blood were significantly elevated.
Positive_regulation (elevated) of Gene_expression (levels) of gastrin in blood associated with cholecystokinin
17) Confidence 0.16 Published 2003 Journal Tob Induc Dis Section Abstract Doc Link PMC2671550 Disease Relevance 0.79 Pain Relevance 0.39
However, CCK and gastrin levels in the blood were significantly elevated.
Positive_regulation (elevated) of Gene_expression (levels) of gastrin in blood associated with cholecystokinin
18) Confidence 0.16 Published 2003 Journal Tob Induc Dis Section Abstract Doc Link PMC2669561 Disease Relevance 0.79 Pain Relevance 0.39
invasive GAS disease that was
Positive_regulation (invasive) of Gene_expression (disease) of GAS associated with disease
19) Confidence 0.15 Published 2008 Journal Infectious Diseases in Obstetrics and Gynecology Section Body Doc Link PMC2612756 Disease Relevance 2.22 Pain Relevance 0.04
noted that the obstetric patient is especially vulnerable to invasive GAS infection acquired via disrupted mucosal or cutaneous
Positive_regulation (vulnerable) of Gene_expression (infection) of GAS associated with infection
20) Confidence 0.15 Published 2008 Journal Infectious Diseases in Obstetrics and Gynecology Section Body Doc Link PMC2612756 Disease Relevance 1.56 Pain Relevance 0.04

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