INT40750

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Context Info
Confidence 0.78
First Reported 1980
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 61
Total Number 94
Disease Relevance 34.59
Pain Relevance 20.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mif) cell proliferation (Mif) extracellular space (Mif)
aging (Mif) extracellular region (Mif) nucleus (Mif)
Anatomy Link Frequency
bladder 18
urothelial cells 9
macrophages 5
neurons 4
viscera 2
Mif (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 1705 100.00 Very High Very High Very High
cytokine 397 100.00 Very High Very High Very High
aspirin 5 100.00 Very High Very High Very High
lidocaine 321 99.92 Very High Very High Very High
Spinal cord 447 99.60 Very High Very High Very High
narcan 18 99.16 Very High Very High Very High
Neurotransmitter 71 99.08 Very High Very High Very High
Enkephalin 10 99.00 Very High Very High Very High
ischemia 484 98.96 Very High Very High Very High
Inflammatory stimuli 205 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1857 100.00 Very High Very High Very High
Overactive Bladder 24 99.88 Very High Very High Very High
Injury 326 99.76 Very High Very High Very High
Cystitis 382 99.42 Very High Very High Very High
Skin Cancer 9 99.40 Very High Very High Very High
Ocular Hypertension 282 99.32 Very High Very High Very High
Cv Unclassified Under Development 484 98.96 Very High Very High Very High
Disease 107 98.56 Very High Very High Very High
Reperfusion Injury 21 97.60 Very High Very High Very High
Stress 164 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the L6-S1 dorsal root ganglia (DRG) that provide afferent innervation to the bladder [13] and other pelvic viscera constitutively expressed MIF.
Gene_expression (expressed) of MIF in viscera
1) Confidence 0.78 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0.39 Pain Relevance 0.19
Basal cells in the urothelium undergo proliferation to give rise to the intermediate and superficial layers [18] and MIF expression was correlated with cell differentiation in the lens [17].
Gene_expression (expression) of MIF in Basal cells
2) Confidence 0.78 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0 Pain Relevance 0
These findings provide anatomical localization for our previous report of constitutive expression of MIF in the MPG previously [10,11].
Gene_expression (expression) of MIF
3) Confidence 0.78 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0.49 Pain Relevance 0.15
Further examination showed that levels of both MIF and the MIF receptor CD74 were substantially increased within the ipsilateral spinal cord dorsal horn after formalin administration.
Gene_expression (levels) of MIF receptor CD74 in spinal cord dorsal horn associated with dorsal horn and spinal cord
4) Confidence 0.75 Published 2010 Journal Pain Section Abstract Doc Link 20005040 Disease Relevance 0.57 Pain Relevance 0.61
Further examination showed that levels of both MIF and the MIF receptor CD74 were substantially increased within the ipsilateral spinal cord dorsal horn after formalin administration.
Gene_expression (levels) of MIF in spinal cord dorsal horn associated with dorsal horn and spinal cord
5) Confidence 0.75 Published 2010 Journal Pain Section Abstract Doc Link 20005040 Disease Relevance 0.57 Pain Relevance 0.60
Bladder MIF and SDF-1 levels are expressed normalized to protein amount (BCA, Thermo Scientific) present in the samples.
Gene_expression (expressed) of MIF in Bladder
6) Confidence 0.74 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0 Pain Relevance 0
In addition, we document that UROtsa cells express MIF and we show, using dual-immunofluorescence that UROtsa cells can express PAR1 and MIF simultaneously.
Gene_expression (express) of MIF
7) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0.37 Pain Relevance 0.10
Inflammatory stimuli elicit MIF release from the urothelium into the bladder lumen and upregulation of MIF expression by the bladder in general and urothelium in particular [8], [9].
Gene_expression (expression) of MIF in lumen associated with inflammatory stimuli
8) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0.62 Pain Relevance 0.37
Thrombin induced upregulation of MIF expression in rat bladder tissue was determined by real time PCR.
Gene_expression (expression) of MIF in bladder
9) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0 Pain Relevance 0
In addition, we document that UROtsa cells express MIF and we show, using dual-immunofluorescence that UROtsa cells can express PAR1 and MIF simultaneously.
Gene_expression (express) of MIF
10) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0.38 Pain Relevance 0.11
MIF is constitutively expressed by urothelial cells and mediates inflammation in the bladder [6], [7].
Gene_expression (expressed) of MIF in bladder associated with inflammation
11) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0.49 Pain Relevance 0.33
Therefore, release of urothelial preformed MIF and activation of MIF production in the bladder (and urothelium in particular) by inflammatory stimuli are key elements in MIF-mediated bladder inflammation.
Gene_expression (production) of MIF in bladder associated with inflammation and inflammatory stimuli
12) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0.77 Pain Relevance 0.45
Given that both human and rat urothelial cells were shown to express both MIF and PAR1 we consider it likely that thrombin stimulated PAR1 receptors on rat urothelial cells to elicit MIF release.
Gene_expression (express) of MIF in urothelial cells
13) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013117 Disease Relevance 0.06 Pain Relevance 0.03
The present findings provide anatomical evidence of MIF protein in the bladder and prostate epithelia of the rat and confirm our earlier findings demonstrating MIF expression in the bladder by immunohistochemistry, Western blotting analysis and RT-PCR [10,11].
Gene_expression (expression) of MIF in bladder
14) Confidence 0.68 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0.24 Pain Relevance 0
These differences in epithelial MIF staining within the bladder and the prostate suggest a change in MIF synthesis as epithelia undergo differentiation as has been reported for the eye lens [17].
Gene_expression (synthesis) of MIF in bladder
15) Confidence 0.68 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0.05 Pain Relevance 0.03
Therefore, neurons in the brain appear to synthesize MIF and quickly release it so that nearby glial cells accumulate MIF protein, without synthesizing it.
Gene_expression (synthesize) of MIF in brain
16) Confidence 0.68 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0 Pain Relevance 0.41
We conclude that significant increases in bladder MIF expression and protein in response to intravesical LPS may represent part of this organ's initial innate immune response.
Gene_expression (expression) of MIF in bladder
17) Confidence 0.68 Published 2004 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 14980085 Disease Relevance 0.59 Pain Relevance 0.45
The pituitary also produces prolactin (PRL), which is pro-inflammatory, and macrophage inhibitory factor (MIF), which by counteracting the anti-inflammatory and immunosuppressive effects of CS, is pro-inflammatory.
Gene_expression (produces) of macrophage inhibitory factor in macrophage associated with corticosteroid and inflammation
18) Confidence 0.68 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11268412 Disease Relevance 1.33 Pain Relevance 0.81
Control sections that were exposed to both the MIF blocking peptide and the antiserum or those that did not receive primary antiserum to MIF, did not show any immunoreactivity (data not shown).
Gene_expression (exposed) of MIF blocking peptide
19) Confidence 0.67 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0.07 Pain Relevance 0.11
Thus, MIF staining was observed in sympathetic and parasympathetic cells of the MPG.
Gene_expression (staining) of MIF in parasympathetic
20) Confidence 0.67 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0.08 Pain Relevance 0

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