INT40776

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Context Info
Confidence 0.77
First Reported 1982
Last Reported 2010
Negated 3
Speculated 4
Reported most in Abstract
Documents 99
Total Number 105
Disease Relevance 34.91
Pain Relevance 24.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt1) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1)
Anatomy Link Frequency
neurons 6
dorsal horn 5
liver 3
neurite 3
brain structures 2
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 110 99.96 Very High Very High Very High
qutenza 80 99.84 Very High Very High Very High
Dopamine 758 99.68 Very High Very High Very High
Nucleus accumbens 26 99.68 Very High Very High Very High
dopamine receptor 80 99.52 Very High Very High Very High
Hippocampus 9 99.52 Very High Very High Very High
Dorsal horn 19 99.44 Very High Very High Very High
spinal dorsal horn 7 99.24 Very High Very High Very High
Paracetamol 660 99.12 Very High Very High Very High
agonist 284 99.06 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 280 100.00 Very High Very High Very High
Aging 420 99.92 Very High Very High Very High
Hepatitis 231 99.84 Very High Very High Very High
Hypertrophy 15 99.72 Very High Very High Very High
Cirrhosis 399 99.56 Very High Very High Very High
Stress 104 99.46 Very High Very High Very High
Disease 218 99.36 Very High Very High Very High
Chronic Hepatitis 217 99.00 Very High Very High Very High
Recurrence 2 98.80 Very High Very High Very High
Lactic Acidosis 1 97.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, levels of Akt and phospho-Akt in all experimental groups remained unchanged.
Gene_expression (levels) of Akt
1) Confidence 0.77 Published 2009 Journal Pharmacol Rep Section Abstract Doc Link 19815943 Disease Relevance 0.81 Pain Relevance 0.45
Moreover, levels of Akt and phospho-Akt in all experimental groups remained unchanged.
Gene_expression (levels) of Akt
2) Confidence 0.77 Published 2009 Journal Pharmacol Rep Section Abstract Doc Link 19815943 Disease Relevance 0.81 Pain Relevance 0.45
ERK and Akt are activated by phosphorylation, hence the levels of phosphorylated ERK (pERK) and Akt (pAkt) as well as total levels of ERK and Akt protein were measured by Western blot analysis.
Gene_expression (levels) of Akt
3) Confidence 0.77 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15056728 Disease Relevance 0 Pain Relevance 0.78
Phosphorylated Akt levels in the nucleus accumbens were significantly increased after a single morphine injection.
Gene_expression (levels) of Akt in nucleus accumbens associated with nucleus accumbens and morphine
4) Confidence 0.77 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15056728 Disease Relevance 0 Pain Relevance 1.09
ERK and Akt are activated by phosphorylation, hence the levels of phosphorylated ERK (pERK) and Akt (pAkt) as well as total levels of ERK and Akt protein were measured by Western blot analysis.
Gene_expression (levels) of Akt
5) Confidence 0.77 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15056728 Disease Relevance 0 Pain Relevance 0.71
In this study, we show that in naive animals almost all cells express Akt but only a subset of small-diameter neurons expresses a high level of phospho-Akt (p-Akt Ser 473).
Gene_expression (expresses) of Akt in neurons
6) Confidence 0.77 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15869474 Disease Relevance 0.48 Pain Relevance 0.51
In this study, we show that in naive animals almost all cells express Akt but only a subset of small-diameter neurons expresses a high level of phospho-Akt (p-Akt Ser 473).
Gene_expression (express) of Akt in neurons
7) Confidence 0.77 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15869474 Disease Relevance 0.42 Pain Relevance 0.45
Double immunofluorescence staining showed that p-PKB/Akt expressed entirely in DRG neurons, especially in IB4-positive neurons.
Gene_expression (expressed) of Akt in neurons
8) Confidence 0.76 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17628541 Disease Relevance 0.65 Pain Relevance 0.91
Total PKB/Akt was detected in all hepatic diseases as a single 60 kDa protein.
Gene_expression (detected) of Akt associated with disease
9) Confidence 0.75 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.84 Pain Relevance 0
Threonine (Thr)-phosphorylated PKB/Akt was less present in AH and CIRR, whereas CH and LDH showed no apparent quantitative differences toward healthy controls.
Gene_expression (present) of Akt associated with chronic hepatitis, cirrhosis and hepatitis
10) Confidence 0.75 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.97 Pain Relevance 0
ERK and Akt are activated by phosphorylation, hence the levels of phosphorylated ERK (pERK) and Akt (pAkt) as well as total levels of ERK and Akt protein were measured by Western blot analysis.
Gene_expression (levels) of pAkt
11) Confidence 0.67 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15056728 Disease Relevance 0 Pain Relevance 0.72
In this study, we show that in naive animals almost all cells express Akt but only a subset of small-diameter neurons expresses a high level of phospho-Akt (p-Akt Ser 473).
Gene_expression (expresses) of p-Akt Ser 473 in neurons
12) Confidence 0.67 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15869474 Disease Relevance 0.48 Pain Relevance 0.51
Western blot analysis on STAT3, PKB/Akt, ERK1/2, and p38MAPK in canine liver homogenates
Gene_expression (/) of Akt in liver
13) Confidence 0.65 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.45 Pain Relevance 0.03
Western blot analysis on STAT3, PKB/Akt, ERK1/2, and p38MAPK in canine liver homogenates
Gene_expression (analysis) of Akt in liver
14) Confidence 0.65 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.50 Pain Relevance 0.03
Treatment of the cells with Shh or instrinsic Shh gene overexpression in response to various factors involve signaling pathways including PI3K/Akt, Ras/ERK and PKC.
Gene_expression (pathways) of Akt
15) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797399 Disease Relevance 0.07 Pain Relevance 0
Threonine (Thr)-phosphorylated PKB/Akt was less present in AH and CIRR, whereas CH and LDH showed no apparent quantitative differences toward healthy controls.
Gene_expression (present) of Akt associated with chronic hepatitis, cirrhosis and hepatitis
16) Confidence 0.65 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.97 Pain Relevance 0
Western blot analysis on STAT3, PKB/Akt, ERK1/2, and p38MAPK in canine liver homogenates
Gene_expression (/) of Akt in liver
17) Confidence 0.65 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.44 Pain Relevance 0.03
We demonstrated that phospho-PKB/Akt (p-PKB/Akt) is increased in dorsal root ganglia (DRG) at 5 min after intradermal injection of capsaicin. p-PKB/Akt is distributed predominantly in small- and medium-sized DRG cells.
Gene_expression (distributed) of Akt in dorsal root ganglia associated with qutenza
18) Confidence 0.65 Published 2007 Journal Neuroscience Section Abstract Doc Link 17084039 Disease Relevance 0.42 Pain Relevance 0.80
The main findings were found seven days after SNT, when there was an increase in HNE-Michael adducts formation, total and p-Akt expression, and H(2)O(2) concentration.
Gene_expression (expression) of p-Akt
19) Confidence 0.65 Published 2008 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 18379870 Disease Relevance 0.77 Pain Relevance 0.76
Akt dysfunction is associated with increases in myocyte apoptosis
Gene_expression (dysfunction) of Akt in myocyte associated with apoptosis
20) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.18 Pain Relevance 0.36

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