INT40777

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Context Info
Confidence 0.69
First Reported 1982
Last Reported 2010
Negated 2
Speculated 7
Reported most in Body
Documents 163
Total Number 195
Disease Relevance 59.41
Pain Relevance 49.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt1) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1)
Anatomy Link Frequency
neurons 10
neuronal 8
dorsal horn 5
dorsal root ganglia 5
brain 4
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 1320 100.00 Very High Very High Very High
Pain 182 100.00 Very High Very High Very High
Morphine 121 100.00 Very High Very High Very High
qutenza 90 100.00 Very High Very High Very High
Nucleus accumbens 18 100.00 Very High Very High Very High
neuralgia 17 100.00 Very High Very High Very High
nociceptor 14 100.00 Very High Very High Very High
agonist 510 99.98 Very High Very High Very High
Neuropathic pain 30 99.84 Very High Very High Very High
bDMF 144 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1120 99.84 Very High Very High Very High
Aging 425 99.84 Very High Very High Very High
Targeted Disruption 114 99.84 Very High Very High Very High
Neuropathic Pain 34 99.84 Very High Very High Very High
Gliosis 12 99.76 Very High Very High Very High
Cv General 4 Under Development 432 99.72 Very High Very High Very High
Neuroblastoma 11 99.64 Very High Very High Very High
Stress 260 99.62 Very High Very High Very High
Fistula 190 99.62 Very High Very High Very High
Myocardial Infarction 685 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intradermal injection of capsaicin results in activation of PKB/Akt in the lumbar spinal cord, most prominently in the dorsal horn, starting by 5 min after capsaicin injection and lasting at least 1h.
Positive_regulation (activation) of Akt in dorsal horn associated with qutenza, dorsal horn and spinal cord
1) Confidence 0.69 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.30 Pain Relevance 0.55
The present study examined the regulation of ERK and Akt activation in the nucleus accumbens and caudate putamen following acute and chronic morphine administration in the rat.
Spec (examined) Positive_regulation (activation) of Akt in caudate putamen associated with nucleus accumbens and morphine
2) Confidence 0.69 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15056728 Disease Relevance 0 Pain Relevance 0.53
When P7 rats (at the peak of brain development) were exposed to a commonly-used and highly pro-apoptotic anesthesia protocol (midazolam, isoflurane, nitrous oxide) for a period of 2, 4 or 6 h, we found that anesthesia modulates the key steps in BDNF-activated apoptotic cascade in two of the most vulnerable brain regions--cerebral cortex and thalamus in time-dependent fashion by activating both Trk-dependent (in thalamus) and Trk-independent p75NTR dependent (in cerebral cortex) neurotrophic pathways. beta-estradiol, a sex hormone that upregulates the protein levels of the activated Akt, protects against anesthesia-induced neuroapoptosis.
Positive_regulation (upregulates) of Akt in brain associated with anesthesia, versed, thalamus, isoflurane, apoptosis and cerebral cortex
3) Confidence 0.68 Published 2006 Journal Apoptosis Section Abstract Doc Link 16738805 Disease Relevance 0.32 Pain Relevance 0.68
Activation of phosphatidylinositol 3-kinase and protein kinase B/Akt in dorsal root ganglia and spinal cord contributes to the neuropathic pain induced by spinal nerve ligation in rats.
Positive_regulation (Activation) of Akt in dorsal root ganglia associated with neuralgia, spinal nerve ligature, neuropathic pain and spinal cord
4) Confidence 0.68 Published 2007 Journal Exp. Neurol. Section Title Doc Link 17628541 Disease Relevance 0.41 Pain Relevance 1.04
Immunohistochemistry revealed that intrathecal injection of wortmannin significantly inhibited the activation of PKB/Akt in L5 DRG and L5 spinal cord.
Positive_regulation (activation) of Akt in DRG associated with spinal cord and intrathecal
5) Confidence 0.68 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17628541 Disease Relevance 0.50 Pain Relevance 0.84
Intradermal injection of capsaicin results in activation of PKB/Akt in the lumbar spinal cord, most prominently in the dorsal horn, starting by 5 min after capsaicin injection and lasting at least 1h.
Positive_regulation (activation) of PKB in dorsal horn associated with qutenza, dorsal horn and spinal cord
6) Confidence 0.67 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.25 Pain Relevance 0.55
In this study, we investigated whether PKB/Akt in primary sensory neurons is activated after noxious stimulation and contributes to pain behavior induced in rats by capsaicin.
Spec (whether) Positive_regulation (activated) of Akt in primary sensory neurons associated with pain and qutenza
7) Confidence 0.67 Published 2007 Journal Neuroscience Section Abstract Doc Link 17084039 Disease Relevance 0.46 Pain Relevance 0.72
Activation of protein kinase B/Akt in the periphery contributes to pain behavior induced by capsaicin in rats.
Positive_regulation (Activation) of Akt associated with pain and qutenza
8) Confidence 0.67 Published 2007 Journal Neuroscience Section Title Doc Link 17084039 Disease Relevance 0.42 Pain Relevance 1.07
Activation of Akt requires the phosphorylation of Ser473 within the carboxyl-terminal hydrophobic motif, which primarily facilitates the phosphorylation of Thr308 in the activation loop to fully activate Akt kinase activity [12].
Positive_regulation (activate) of Akt kinase
9) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.46 Pain Relevance 0.14
We found that both the abundance of S-nitrosylated Akt and ratio of S-nitrosylated Akt/total Akt were substantially increased with aging (Figure 5A).
Positive_regulation (increased) of Akt associated with aging
10) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.47 Pain Relevance 0.16
Activation of Akt requires the phosphorylation of Ser473 within the carboxyl-terminal hydrophobic motif, which primarily facilitates the phosphorylation of Thr308 in the activation loop to fully activate Akt kinase activity [12].
Positive_regulation (Activation) of Akt
11) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.49 Pain Relevance 0.21
Increase in reactive oxygen species and activation of Akt signaling pathway in neuropathic pain.
Positive_regulation (activation) of Akt associated with neuralgia and neuropathic pain
12) Confidence 0.66 Published 2008 Journal Cell. Mol. Neurobiol. Section Title Doc Link 18379870 Disease Relevance 0.70 Pain Relevance 0.91
Wortmannin blocked FBF, MXD, and liver P-Akt/Akt increases from 10 mU.min-1.kg-1 insulin.
Positive_regulation (increases) of Akt in liver
13) Confidence 0.61 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17106063 Disease Relevance 0.50 Pain Relevance 0.06
In present study, the abundance of pAkt-Ser473 was higher in muscles obtained from both the 33-month control and acetaminophen-treated rats, while pAkt-Thr308 was dramatically increased in control rats.
Positive_regulation (increased) of pAkt-Thr308 in muscles associated with paracetamol
14) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.30 Pain Relevance 0.41
It is known that Akt is activated by oxidative stress in a variety of cell types, including renal cells.
Positive_regulation (activated) of Akt associated with stress
15) Confidence 0.57 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.70 Pain Relevance 0
High glucose activates the PI 3-kinase/Akt/mTOR signaling cascade to stimulate protein synthesis (37).
Positive_regulation (activates) of Akt
16) Confidence 0.57 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.71 Pain Relevance 0
Importantly, we show that ROS, and specifically hydrogen peroxide, directly induce Akt activation and tuberin phosphorylation, resulting in downregulation of OGG1 in MCT cells, indicating that ROS are potential upstream mediators of the effects of high glucose on oxidative DNA damage.
Positive_regulation (activation) of Akt
17) Confidence 0.57 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.64 Pain Relevance 0
Thus, activation of Akt represents a very proximal step in the intracellular signaling pathway triggered by high glucose.
Positive_regulation (activation) of Akt in proximal
18) Confidence 0.57 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.57 Pain Relevance 0
PI 3-kinaseĀ–dependent activation of Akt in response to glucose has been demonstrated in MCT cells (37).
Positive_regulation (activation) of Akt
19) Confidence 0.57 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0 Pain Relevance 0
This rapid effect supports the contention that ROS mediate early signaling events, such as Akt activation in response to high glucose.
Positive_regulation (activation) of Akt
20) Confidence 0.57 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.52 Pain Relevance 0

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