INT40782

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Context Info
Confidence 0.57
First Reported 1981
Last Reported 2007
Negated 2
Speculated 2
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 4.59
Pain Relevance 5.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc7a2) transmembrane transport (Slc7a2) cytoplasm (Slc7a2)
Anatomy Link Frequency
leaf 2
blood 1
Slc7a2 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 183 100.00 Very High Very High Very High
Action potential 306 99.84 Very High Very High Very High
Inflammation 64 99.38 Very High Very High Very High
cytokine 34 99.08 Very High Very High Very High
Enkephalin 20 98.04 Very High Very High Very High
potassium channel 15 94.44 High High
sodium channel 69 93.68 High High
addiction 60 90.80 High High
tolerance 62 86.64 High High
Inflammatory response 12 82.88 Quite High
Disease Link Frequency Relevance Heat
Asthma 66 100.00 Very High Very High Very High
Diabetes Mellitus 302 99.84 Very High Very High Very High
INFLAMMATION 76 99.38 Very High Very High Very High
Nicotine Addiction 92 98.40 Very High Very High Very High
Pneumonia 8 97.28 Very High Very High Very High
Rhinitis 10 94.60 High High
Insulin Resistance 12 93.64 High High
Obesity 18 89.40 High High
Impaired Glucose Tolerance 42 86.64 High High
Injury 11 76.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To clarify the status of these genes, the same RNA samples that had been subjected to the microarray assay underwent qRT-PCR to determine differential expression of 14 genes previously associated with asthma by other investigators (Arg1, Ccl8, Ccl11, Ccl24, Ear11, Mcpt1, Sprr2a, Chi3l3, Chi3l4, Chia, Pde4b, Pde4d, Slc7a2, Tgfb1), as well as 7 cytokine genes associated with asthma and/or pulmonary inflammation (Ifn?
Spec (determine) Gene_expression (expression) of Slc7a2 associated with asthma, inflammation, pneumonia and cytokine
1) Confidence 0.57 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 0.38 Pain Relevance 0.14
However, the few asthma/inflammatory genes that are differentially expressed (Pik3cd, Arg1, Slc7a2, Ccl24, Mcpt1) are all up-regulated in ETS-exposed mice.
Gene_expression (expressed) of Slc7a2 associated with asthma, nicotine addiction and inflammation
2) Confidence 0.57 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137099 Disease Relevance 1.29 Pain Relevance 0.30
Compared with stimulation in the absence of TEA, the rate constant was 8 times greater for [Leu]enkephalin and 20 times greater for [Met]enkephalin.
Neg (absence) Gene_expression (absence) of TEA associated with enkephalin
3) Confidence 0.53 Published 1981 Journal Proc. R. Soc. Lond., B, Biol. Sci. Section Abstract Doc Link 6120513 Disease Relevance 0 Pain Relevance 1.28
For this group of cells tested in the presence of TEA, 4-AP as well as TTX, AP amplitude decreased gradually for Vh values between -60 and -20 (Figure 4).
Gene_expression (presence) of TEA associated with tetrodotoxin and action potential
4) Confidence 0.27 Published 2007 Journal Mol Pain Section Body Doc Link PMC1892009 Disease Relevance 0 Pain Relevance 0.96
An example of currents produced by this protocol for two cells, one in the absence (A) and one in the presence (B) of TEA and 4-AP are shown in Figure 3.
Gene_expression (produced) of TEA associated with action potential
5) Confidence 0.24 Published 2007 Journal Mol Pain Section Body Doc Link PMC1892009 Disease Relevance 0 Pain Relevance 1.07
To test this hypothesis, we performed the same AP amplitude/Vh analysis in the presence of TTX (300 nM), TEA (25 mM) and 4-AP (3 mM) to block a significant portion of outward potassium current.
Gene_expression (presence) of TEA associated with tetrodotoxin and action potential
6) Confidence 0.24 Published 2007 Journal Mol Pain Section Body Doc Link PMC1892009 Disease Relevance 0.05 Pain Relevance 1.15
These results suggest that both fresh green tea leaf extract and green tea suspension lower BGL without changing serum insulin concentration.


Gene_expression (suspension) of tea in leaf
7) Confidence 0.14 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC517497 Disease Relevance 0.65 Pain Relevance 0
No elevation of blood insulin levels was observed during the decrease in BGL either by tea leaf extract or by green tea suspension in STZ-diabetic mice (data not shown).
Gene_expression (leaf) of tea in leaf associated with diabetes mellitus
8) Confidence 0.14 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC517497 Disease Relevance 0.70 Pain Relevance 0
Especially, to determine the significance of the time-dependent effects of green tea (Fig. 1 and 2) on the blood glucose levels, repeated measures ANOVA was performed, and then, if the statistical significance was detected by this analysis, further statistical comparison at each measurement time between the groups was conducted by one-way ANOVA, followed by the Scheffé test.


Spec (determine) Gene_expression (effects) of tea in blood
9) Confidence 0.14 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC517497 Disease Relevance 0 Pain Relevance 0
In the present study, we demonstrated that green tea produces an antihyperglycemic effect without affecting insulin secretion in STZ-diabetic mice.
Neg (without) Gene_expression (produces) of tea associated with diabetes mellitus
10) Confidence 0.14 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC517497 Disease Relevance 0.30 Pain Relevance 0
Antihyperglycemic effects of green tea in diabetic mice
Gene_expression (effects) of tea associated with diabetes mellitus
11) Confidence 0.14 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC517497 Disease Relevance 0.67 Pain Relevance 0.12
Since the administration of green tea produced an acute antihyperglycemic effect on BGL in diabetic mice in the present study, additional mechanisms, such as changes in amelioration or enhancement of insulin action, should be clarified in a future study.
Gene_expression (produced) of tea associated with diabetes mellitus
12) Confidence 0.12 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC517497 Disease Relevance 0.56 Pain Relevance 0

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