INT40800

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Context Info
Confidence 0.61
First Reported 1982
Last Reported 2009
Negated 1
Speculated 0
Reported most in Title
Documents 8
Total Number 8
Disease Relevance 1.82
Pain Relevance 4.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
nucleus 3
sertoli cells 2
hippocampus 1
Oprl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 12 100.00 Very High Very High Very High
cocaine 8 100.00 Very High Very High Very High
Opioid 8 100.00 Very High Very High Very High
Kappa opioid receptor 6 100.00 Very High Very High Very High
opiate 4 100.00 Very High Very High Very High
orphanin 3 100.00 Very High Very High Very High
narcan 6 99.62 Very High Very High Very High
dexamethasone 24 99.26 Very High Very High Very High
Hippocampus 3 98.04 Very High Very High Very High
antagonist 1 97.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 6 99.48 Very High Very High Very High
Neuropathic Pain 4 94.96 High High
Pulmonary Disease 3 94.28 High High
Respiratory Distress 3 92.44 High High
Critical Illness 3 87.84 High High
Cerebral Palsy 6 85.48 High High
Nervous System Injury 2 75.00 Quite High
Pain 3 67.80 Quite High
Nociception 1 67.08 Quite High
Stupor 1 66.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of single and dual administration of cocaine and ethanol on opioid and ORL1 receptor expression in rat CNS: an autoradiographic study.
Regulation (Effects) of Gene_expression (expression) of ORL1 receptor associated with opioid and cocaine
1) Confidence 0.61 Published 2003 Journal Brain Res. Section Title Doc Link 12834892 Disease Relevance 0 Pain Relevance 0.90
Dexamethasone exposure during the neonatal period alters ORL1 mRNA expression in the hypothalamic paraventricular nucleus and hippocampus of the adult rat.
Regulation (alters) of Gene_expression (expression) of ORL1 in nucleus associated with hippocampus and dexamethasone
2) Confidence 0.45 Published 2003 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 14643007 Disease Relevance 0.57 Pain Relevance 0.50
Naloxone: analeptic action unrelated to opiate receptor antagonism?
Regulation (unrelated) of Gene_expression (antagonism) of opiate receptor associated with narcan and opiate
3) Confidence 0.45 Published 1982 Journal Anesthesiology Section Title Doc Link 6121523 Disease Relevance 0.07 Pain Relevance 0.86
These results suggest that prolonged glucocorticoid receptor (GR) occupation in the neonatal period leads to permanent alterations in ORL1 expression in the LHPA stress axis of the adult rat.
Regulation (alterations) of Gene_expression (expression) of ORL1 associated with stress
4) Confidence 0.27 Published 2003 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 14643007 Disease Relevance 0.22 Pain Relevance 0.41
No significant changes were observed for either the nociceptin precursor or mu-opioid receptor expression.
Neg (No) Regulation (changes) of Gene_expression (expression) of nociceptin precursor associated with orphanin and opioid receptor
5) Confidence 0.27 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12106803 Disease Relevance 0.38 Pain Relevance 0.69
These alterations in the kappa opioid receptor expression are possibly attributed to a previously observed pronounced impact of nandrolone decanoate on the dynorphinergic system and could also include involvement of the dopaminergic reward system.
Regulation (alterations) of Gene_expression (expression) of kappa opioid receptor associated with kappa opioid receptor
6) Confidence 0.26 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19201466 Disease Relevance 0 Pain Relevance 0.28
Dexamethasone exposure during the neonatal period alters ORL1 mRNA expression in the hypothalamic paraventricular nucleus and hippocampus of the adult rat.
Regulation (alters) of in hippocampus Gene_expression (expression) of ORL1 in nucleus associated with hippocampus and dexamethasone
7) Confidence 0.15 Published 2003 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 14643007 Disease Relevance 0.57 Pain Relevance 0.50
Interleukin-6 regulation of kappa opioid receptor gene expression in primary sertoli cells.
Regulation (regulation) of Gene_expression (expression) of kappa opioid receptor gene in sertoli cells associated with kappa opioid receptor
8) Confidence 0.13 Published 2000 Journal Endocrine Section Title Doc Link 11051042 Disease Relevance 0 Pain Relevance 0.60

General Comments

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