INT40817

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Context Info
Confidence 0.26
First Reported 1981
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.98
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pla2g1b) extracellular space (Pla2g1b) extracellular region (Pla2g1b)
response to stress (Pla2g1b)
Pla2g1b (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 2 99.98 Very High Very High Very High
IPN 1 98.56 Very High Very High Very High
Thermal hyperalgesia 1 94.64 High High
Pain 5 93.36 High High
aspirin 52 92.40 High High
nMDA receptor 1 92.24 High High
Spinal cord 13 91.04 High High
Hyperalgesia 3 88.28 High High
bradykinin 1 84.68 Quite High
cINOD 18 83.20 Quite High
Disease Link Frequency Relevance Heat
Injury 4 99.88 Very High Very High Very High
Inflammatory Pain 1 98.56 Very High Very High Very High
Hyperalgesia 4 94.64 High High
Pain 4 93.36 High High
Asthma 25 93.08 High High
Frailty 8 91.52 High High
INFLAMMATION 11 83.12 Quite High
Nasal Polyps 5 76.20 Quite High
Nociception 1 75.00 Quite High
Spinal Cord Compression 2 72.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect may be of importance in inflammatory pain in that the effect of algogens (including histamine) is enhanced by an increased phospholipase A2-mediated synthesis of prostaglandins.
Positive_regulation (increased) of Gene_expression (synthesis) of phospholipase A2 associated with ipn
1) Confidence 0.26 Published 1981 Journal Agents Actions Section Abstract Doc Link 6122358 Disease Relevance 0.41 Pain Relevance 0.57
Clearly, this was not mediated by increased expression of COX and most likely, therefore, was due to increased expression of phospholipase A2 (19), the enzyme responsible for liberation of the substrate arachidonic acid.
Positive_regulation (increased) of Gene_expression (expression) of phospholipase A2
2) Confidence 0.17 Published 2008 Journal FASEB J Section Body Doc Link PMC2691413 Disease Relevance 0.36 Pain Relevance 0.57
Activation of the N-methyl-D-aspartate (NMDA) receptor results in a calcium-dependent production of nitric oxide, while activation of alpha-amino-3-hydroxy-5-methylisoxazole-5-propionate (AMPA)-and 1,3- trans-1-amino-cyclopentyl-1,3-dicarboxylate (trans-ACPD)-sensitive glutamate receptors results in a phospholipase A2 (PLA2)-mediated production of different intracellular mediators, including arachidonic acid.
Positive_regulation (results) of Gene_expression (production) of phospholipase A2 associated with glutamate receptor
3) Confidence 0.07 Published 1994 Journal Drugs Section Abstract Doc Link 7525181 Disease Relevance 0.34 Pain Relevance 0.60
However, injury also triggers the immediate calcium-mediated activation of phospholipase A2 (PLA2), the release of arachidonic acid, and the enzymatic formation of potentially deleterious prostaglandins (PGE2 alpha, PGE2), thromboxane A2 (TXA2), and leukotrienes (LTs).
Positive_regulation (activation) of Gene_expression (formation) of phospholipase A2 associated with injury
4) Confidence 0.04 Published 1995 Journal J. Neurotrauma Section Abstract Doc Link 7473799 Disease Relevance 0.43 Pain Relevance 0.23
However, injury also triggers the immediate calcium-mediated activation of phospholipase A2 (PLA2), the release of arachidonic acid, and the enzymatic formation of potentially deleterious prostaglandins (PGE2 alpha, PGE2), thromboxane A2 (TXA2), and leukotrienes (LTs).
Positive_regulation (triggers) of Gene_expression (formation) of phospholipase A2 associated with injury
5) Confidence 0.04 Published 1995 Journal J. Neurotrauma Section Abstract Doc Link 7473799 Disease Relevance 0.44 Pain Relevance 0.23

General Comments

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