INT40832

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Context Info
Confidence 0.73
First Reported 1982
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.21
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ADRB2) plasma membrane (ADRB2) nucleus (ADRB2)
lysosome (ADRB2) cytoplasm (ADRB2) signal transducer activity (ADRB2)
Anatomy Link Frequency
coronary artery 1
ADRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 5 100.00 Very High Very High Very High
antagonist 6 99.96 Very High Very High Very High
agonist 6 99.68 Very High Very High Very High
Potency 1 99.48 Very High Very High Very High
cva 5 96.64 Very High Very High Very High
Neurotransmitter 1 90.84 High High
Clonidine 7 86.96 High High
ischemia 4 82.24 Quite High
noradrenaline 7 81.20 Quite High
Serotonin 1 72.36 Quite High
Disease Link Frequency Relevance Heat
Hypertension 4 99.80 Very High Very High Very High
Pheochromocytoma 1 99.04 Very High Very High Very High
Coronary Artery Disease 12 98.58 Very High Very High Very High
Syndrome 4 97.44 Very High Very High Very High
Bradycardia 2 96.92 Very High Very High Very High
Affective Disorder 2 96.64 Very High Very High Very High
Cv General 4 Under Development 1 96.64 Very High Very High Very High
Myocardial Stunning 1 95.28 Very High Very High Very High
Takotsubo Cardiomyopathy 25 91.28 High High
Squamous Cell Carcinoma 1 83.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lithium suppresses signaling and induces rapid sequestration of beta2-adrenergic receptors.
Localization (sequestration) of beta2-adrenergic
1) Confidence 0.73 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 11594766 Disease Relevance 0.18 Pain Relevance 0.22
Pithing or beta-adrenoceptor blockade reduced the potency of ouabain for producing arrhythmias, but bilateral adrenalectomy did not give protection.
Localization (blockade) of beta-adrenoceptor associated with potency
2) Confidence 0.71 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6122584 Disease Relevance 0.32 Pain Relevance 0.28
Isoprenaline (beta 1- and beta 2-adrenoreceptor agonist) and procaterol (beta 2-adrenoreceptor agonist) increased the release, propranolol (beta 1- and beta 2-adrenoreceptor antagonist) reduced it, and prenalterol (beta 1-adrenoreceptor agonist) and atenolol (beta 1-adrenoreceptor antagonist) had no effect.
Localization (release) of beta 2-adrenoreceptor associated with antagonist and agonist
3) Confidence 0.56 Published 1984 Journal J Auton Pharmacol Section Abstract Doc Link 6152266 Disease Relevance 0 Pain Relevance 0.90
These patients were newly diagnosed with coronary artery disease, some of whom were taking vasoactive drugs such as ACE inhibitors and beta adrenoceptor blockers for hypertension prior to study enrolment.
Localization (blockers) of beta adrenoceptor in coronary artery associated with coronary artery disease and hypertension
4) Confidence 0.10 Published 2008 Journal Atherosclerosis Section Body Doc Link PMC2292239 Disease Relevance 0.25 Pain Relevance 0.09
Genetic variations in catecholamine receptor location could place susceptible individuals at increased risk for this syndrome (Van De Walle et al 2006).
Localization (location) of catecholamine receptor associated with syndrome and catecholamine
5) Confidence 0.06 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643117 Disease Relevance 1.46 Pain Relevance 0.31

General Comments

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