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Context Info
Confidence 0.53
First Reported 1982
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 2.88
Pain Relevance 3.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Naga) molecular_function (Naga) cellular_component (Naga)
biological_process (Naga) lysosome (Naga) cytoplasm (Naga)
Anatomy Link Frequency
cleavage 1
brush 1
Naga (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 4 100.00 Very High Very High Very High
Dynorphin 8 99.84 Very High Very High Very High
Paracetamol 33 99.52 Very High Very High Very High
opiate 1 85.44 High High
Opioid 3 77.68 Quite High
Analgesic 3 54.72 Quite High
Disease Link Frequency Relevance Heat
Renal Disease 24 99.78 Very High Very High Very High
Balkan Nephropathy 18 98.92 Very High Very High Very High
Nephrotoxicity 3 92.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only a minor portion of the smallest dynorphin-related molecular weight form, dynorphin-(1-8), released alpha-N-acetyl-leucine-enkephalin upon enzymatic cleavage.
Localization (released) of alpha-N-acetyl-leucine-enkephalin in cleavage associated with dynorphin and enkephalin
1) Confidence 0.53 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 6123547 Disease Relevance 0 Pain Relevance 0.95
After acetaminophen administration urinary excretion of APN, dipeptidylpeptidase IV (DPP IV), gamma-glutamyltranspeptidase (GGT) and N-acetyl-beta-D-glucosaminidase (NAGA) did not increase significantly in any group studied.
Localization (excretion) of NAGA associated with paracetamol
2) Confidence 0.10 Published 1999 Journal Ren Fail Section Abstract Doc Link 10516997 Disease Relevance 0.98 Pain Relevance 0.80
This study has shown that urinary excretion of APN, DPP IV, NAGA and GGT, as markers of kidney brush border and lysosomal damage, did not change after 2 g of acetaminophen taken orally. beta 2-microglobulin was a marker of acute acetaminophen nephrotoxicity in kidney disease patients and in clinically healthy adults from nephropathic families.
Localization (excretion) of NAGA in brush associated with nephrotoxicity, paracetamol and renal disease
3) Confidence 0.09 Published 1999 Journal Ren Fail Section Abstract Doc Link 10516997 Disease Relevance 0.87 Pain Relevance 0.77
Excretion of aminopeptidase N (APN) activity before acetaminophen treatment was significantly higher in patients with GN, however, NAGA excretion was higher in both GN and BEN patients than in healthy controls.
Localization (excretion) of NAGA in BEN associated with paracetamol, balkan nephropathy and renal disease
4) Confidence 0.08 Published 1999 Journal Ren Fail Section Abstract Doc Link 10516997 Disease Relevance 1.03 Pain Relevance 0.90

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