INT40857

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Context Info
Confidence 0.49
First Reported 1982
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.51
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MAOA) small molecule metabolic process (MAOA) oxidoreductase activity (MAOA)
MAOA (Homo sapiens)
Pain Link Frequency Relevance Heat
monoamine 11 100.00 Very High Very High Very High
antidepressant 45 99.46 Very High Very High Very High
sSRI 23 99.36 Very High Very High Very High
Serotonin 15 98.92 Very High Very High Very High
transdermal 20 95.92 Very High Very High Very High
Dopamine 3 82.12 Quite High
fluoxetine 18 82.00 Quite High
Analgesic 5 75.00 Quite High
Central nervous system 4 66.96 Quite High
Neurotransmitter 3 60.52 Quite High
Disease Link Frequency Relevance Heat
Disease 17 99.76 Very High Very High Very High
Diarrhoea 2 98.24 Very High Very High Very High
Pulmonary Hypertension 85 97.92 Very High Very High Very High
Confusion 4 97.68 Very High Very High Very High
Agoraphobia 70 94.64 High High
Panic Disorder 153 93.52 High High
Increased Venous Pressure Under Development 5 93.12 High High
Abnormal Reflex 1 88.56 High High
Tremor 1 87.80 High High
Myoclonus 1 86.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients on monoamine oxidase inhibitors and selective serotonin reuptake inhibitors are at particular risk, and indeed care must be taken with a multiplicity of drugs with similar properties which are frequently used in anaesthesia and intensive care.
Positive_regulation (Patients) of monoamine oxidase associated with ssri and monoamine
1) Confidence 0.49 Published 2008 Journal Crit Care Section Body Doc Link PMC2374627 Disease Relevance 1.05 Pain Relevance 0.14
Experimental studies have demonstrated that the antidepressant-like effect of selegiline requires greater than 70% inhibition of MAO-A activity (Gordon et al 1999).
Positive_regulation (requires) of MAO associated with antidepressant
2) Confidence 0.40 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656289 Disease Relevance 0.05 Pain Relevance 0.41
Selective and reversible MAO-A inhibitors (RIMAs) exemplified by moclobemide and brofaromine do not require dietary restrictions, have fewer drug interactions than irreversible MAO inhibitors, and are better tolerated.
Positive_regulation (require) of MAO
3) Confidence 0.37 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536545 Disease Relevance 0.84 Pain Relevance 0.43
- and fundamental aspects of neuroendocrine regulation - e.g., do the MAO inhibitors stimulate the production of a PRF?
Positive_regulation (stimulate) of MAO
4) Confidence 0.32 Published 1982 Journal Adv. Biochem. Psychopharmacol. Section Abstract Doc Link 6124090 Disease Relevance 0 Pain Relevance 0.28
The upregulation of MAOA is of interest given the "serotonin" hypothesis of pulmonary hypertension.
Positive_regulation (upregulation) of MAOA associated with pulmonary hypertension and serotonin
5) Confidence 0.18 Published 2006 Journal Respir Res Section Body Doc Link PMC1351173 Disease Relevance 0.56 Pain Relevance 0.24
Likewise, no involvement of human monoamine oxidase (isoforms A and B) was found for either flupirtine or D13223.
Neg (no) Positive_regulation (involvement) of monoamine oxidase associated with monoamine
6) Confidence 0.11 Published 2009 Journal Drug Metab. Dispos. Section Abstract Doc Link 19074524 Disease Relevance 0 Pain Relevance 0.20

General Comments

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