INT40900

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Context Info
Confidence 0.07
First Reported 1980
Last Reported 1982
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.56
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PDYN, POMC) small molecule metabolic process (POMC) cell-cell signaling (POMC)
cytoplasm (POMC) extracellular space (POMC) generation of precursor metabolites and energy (POMC)
Anatomy Link Frequency
melanocyte 2
PDYN (Homo sapiens)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 7 100.00 Very High Very High Very High
substance P 1 99.48 Very High Very High Very High
Opioid 1 96.32 Very High Very High Very High
Neuropeptide 4 93.36 High High
Somatostatin 4 92.40 High High
agonist 1 75.00 Quite High
opiate 1 75.00 Quite High
narcan 2 73.44 Quite High
Disease Link Frequency Relevance Heat
Adenoma 2 90.20 High High
Syndrome 3 85.32 High High
Pituitary Cancer 3 83.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of Leu-enkephalin, Met-enkephalin, and beta-endorphin on melanocyte-stimulating hormone (MSH) secretion were studied in vivo and in vitro.
Leu-enkephalin Regulation (effects) of Localization (secretion) of MSH in melanocyte associated with enkephalin
1) Confidence 0.07 Published 1980 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 7378936 Disease Relevance 0 Pain Relevance 0.62
Substance P, TRF, Met-enkephalin and Leu-enkephalin were also found to modulate the secretion of POMC-derived peptides.
Leu-enkephalin Regulation (modulate) of Localization (secretion) of POMC associated with enkephalin and substance p
2) Confidence 0.03 Published 1982 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6126487 Disease Relevance 0.56 Pain Relevance 0.60

General Comments

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