INT40907

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Context Info
Confidence 0.71
First Reported 1982
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Adra2c) cytoplasm (Adra2c) signal transducer activity (Adra2c)
Anatomy Link Frequency
dorsal horn 1
Adra2c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 7 100.00 Very High Very High Very High
Intracerebroventricular 2 99.72 Very High Very High Very High
Potency 4 98.60 Very High Very High Very High
Clonidine 14 98.24 Very High Very High Very High
Spinal cord 2 50.00 Quite Low
Peripheral nerve injury 1 50.00 Quite Low
Analgesic 1 10.00 Low Low
intrathecal 1 5.00 Very Low Very Low Very Low
antinociception 1 5.00 Very Low Very Low Very Low
allodynia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nervous System Injury 2 50.00 Quite Low
Neuropathic Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subcutaneous injection of alpha-adrenoceptor agonists also reduced gastric secretion, in the following order (relative potency, clonidine = 1): clonidine (1) greater than oxymetazoline (0.3), much greater than phenylephrine (0.001) approximately methoxamine (0.0006).
Localization (secretion) of alpha-adrenoceptor associated with agonist, clonidine and potency
1) Confidence 0.71 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6126820 Disease Relevance 0 Pain Relevance 0.80
Intracerebroventricular injection of alpha-adrenoceptor agonists reduced gastric secretion, in the following order (relative potency, clonidine = 1): oxymetazoline (100) greater than clonidine (1) greater than methoxamine (0.024) greater than phenylephrine (0.003).
Localization (secretion) of alpha-adrenoceptor associated with agonist, intracerebroventricular, clonidine and potency
2) Confidence 0.71 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6126820 Disease Relevance 0 Pain Relevance 0.66
Alpha2C adrenoceptors colocalized with cholinergic neurons in both superficial and deep dorsal horn.
Localization (colocalized) of Alpha2C in dorsal horn
3) Confidence 0.25 Published 2003 Journal Anesthesiology Section Body Doc Link 12606922 Disease Relevance 0 Pain Relevance 0

General Comments

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