INT40954

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Context Info
Confidence 0.32
First Reported 1982
Last Reported 2008
Negated 0
Speculated 2
Reported most in Abstract
Documents 5
Total Number 8
Disease Relevance 3.71
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serping1) extracellular region (Serping1) molecular_function (Serping1)
cellular_component (Serping1) biological_process (Serping1)
Serping1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 12 99.36 Very High Very High Very High
Morphine 18 98.84 Very High Very High Very High
abdominal pain 4 97.52 Very High Very High Very High
Antihistamine 2 95.52 Very High Very High Very High
corticosteroid 2 94.80 High High
Potency 4 71.64 Quite High
bradykinin 6 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
iatrogenic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hereditary Angioedema 100 100.00 Very High Very High Very High
Emergencies 4 100.00 Very High Very High Very High
Pressure And Volume Under Development 39 98.92 Very High Very High Very High
Abdominal Pain 4 97.52 Very High Very High Very High
Disease 14 87.12 High High
Infection 38 84.00 Quite High
Fever 2 66.40 Quite High
Hypothermia 2 65.84 Quite High
Catalepsy 2 65.24 Quite High
Urticaria 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that while all three treatment options are theoretically effective in the emergency treatment of HAE, C1-INH is the treatment of choice.
Regulation (effective) of C1-INH associated with hereditary angioedema and emergencies
1) Confidence 0.32 Published 2005 Journal Int. J. Clin. Pract. Section Abstract Doc Link 15857357 Disease Relevance 1.12 Pain Relevance 0.09
Resulting from mutations affecting C1 esterase inhibitor (C1-INH), inhibitor of the first complement system component, attacks are not histamine-mediated and do not respond to antihistamines or corticosteroids.
Regulation (affecting) of C1-INH associated with corticosteroid and antihistamine
2) Confidence 0.25 Published 2004 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 15356535 Disease Relevance 0.87 Pain Relevance 0.19
Resulting from mutations affecting C1 esterase inhibitor (C1-INH), inhibitor of the first complement system component, attacks are not histamine-mediated and do not respond to antihistamines or corticosteroids.
Regulation (affecting) of C1 esterase inhibitor associated with corticosteroid and antihistamine
3) Confidence 0.25 Published 2004 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 15356535 Disease Relevance 0.82 Pain Relevance 0.19
We investigated the effects of oral contraception on their level of C1-INH, functional C1-INH assay and their clinical symptoms.
Spec (investigated) Regulation (effects) of C1-INH
4) Confidence 0.25 Published 2003 Journal Presse Med Section Body Doc Link 12870385 Disease Relevance 0 Pain Relevance 0
The effects of several analogs of melanotropin-release inhibiting factor (MIF, Pro-Leu-Gly-NH2) on the development of tolerance to the hyperthermic, hypothermic and cataleptic actions of morphine were investigated in male Sprague-Dawley rats.
Spec (investigated) Regulation (effects) of melanotropin-release inhibiting factor associated with tolerance and morphine
5) Confidence 0.09 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 6128692 Disease Relevance 0 Pain Relevance 0.48
Effect of melanotropin-release inhibiting factor and analogs on tolerance to morphine in the rat.
Regulation (Effect) of melanotropin-release inhibiting factor associated with tolerance and morphine
6) Confidence 0.06 Published 1982 Journal Neuropharmacology Section Title Doc Link 6128692 Disease Relevance 0.20 Pain Relevance 0.89
These authors, however, used another methodology which did not enable the exclusion of an influence of endogenous C4 and C1-INH and, because of that, their results are difficult to compare with ours.
Regulation (influence) of C1-INH
7) Confidence 0.04 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2734250 Disease Relevance 0.42 Pain Relevance 0.04
We also compared the values for C1-INH biological activity with those for MBL pathway activity in each patient, but no correlation was observed (r= -0.08, p=0.56; Fig. 1).


Regulation (values) of C1-INH
8) Confidence 0.04 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2734250 Disease Relevance 0.29 Pain Relevance 0

General Comments

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