INT4096

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Context Info
Confidence 0.58
First Reported 1976
Last Reported 2006
Negated 1
Speculated 1
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 3.97
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pth) extracellular region (Pth) cellular_component (Pth)
Anatomy Link Frequency
parathyroid glands 4
parathyroid 4
body 4
thyroid 2
Pth (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 3 99.84 Very High Very High Very High
Dismenorea 3 88.20 High High
depression 2 83.20 Quite High
fibrosis 12 78.24 Quite High
peptic ulcer disease 1 70.56 Quite High
cytokine 6 66.40 Quite High
Pain 7 63.12 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 4 99.98 Very High Very High Very High
Chronic Renal Failure 84 99.84 Very High Very High Very High
Hypercalcemia 116 98.72 Very High Very High Very High
Left Ventricular Hypertrophy 6 98.64 Very High Very High Very High
Calcification 15 96.92 Very High Very High Very High
Bone Cancer 9 94.40 High High
Parathyroid Cancer 13 93.28 High High
Hypocalcemia 2 92.80 High High
Reprotox - General 1 3 88.20 High High
Disease 11 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vitamin D receptors are dispersed throughout the body in a number of tissues, and activation of these receptors may affect not only secretion of PTH but also modulation of the renin┬ľangiotensin system, left ventricular hypertrophy, and vascular calcification (Levin and Li 2005).
Spec (may) Regulation (affect) of Localization (secretion) of PTH in body associated with calcification and left ventricular hypertrophy
1) Confidence 0.58 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.44 Pain Relevance 0.10
Based on the evidence presented above, oral paricalcitol is able to effectively control PTH secretion in CKD patients when compared with placebo.
Regulation (control) of Localization (secretion) of PTH associated with chronic renal failure
2) Confidence 0.58 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.87 Pain Relevance 0
REVIEW: The paper reviews the physiologic regulation of PTH secretion and types and forms of HPT.
Regulation (regulation) of Localization (secretion) of PTH
3) Confidence 0.46 Published 2005 Journal Clin. Chim. Acta Section Body Doc Link 15698586 Disease Relevance 0 Pain Relevance 0
We conclude that enkephalins do not influence the secretion and metabolism of the parathyroid hormone, but block its peripheral effects and stimulate thyroid C-cell function.
Neg (not) Regulation (influence) of Localization (secretion) of parathyroid hormone in thyroid associated with enkephalin
4) Confidence 0.45 Published 1986 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 3025768 Disease Relevance 0 Pain Relevance 0.26
The osteoblastic effect of inorganic phosphorus and the inhibitory action of calcium on parathyroid hormone secretion formed the basis for a therapeutic trial in which both elements were given intravenously in an alternating sequence for one year to five patients with severe osteoporosis.
Regulation (effect) of Localization (secretion) of parathyroid hormone in parathyroid associated with osteoporosis
5) Confidence 0.43 Published 1976 Journal Am. J. Med. Section Abstract Doc Link 973642 Disease Relevance 0.39 Pain Relevance 0.06
Vitamin D receptors are dispersed throughout the body in a number of tissues, and activation of these receptors may affect not only secretion of PTH but also modulation of the renin┬ľangiotensin system, left ventricular hypertrophy, and vascular calcification (Levin and Li 2005).
Regulation (modulation) of Localization (secretion) of PTH in body associated with calcification and left ventricular hypertrophy
6) Confidence 0.42 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.44 Pain Relevance 0.10
The mechanism by which cimetidine affects calcium transport may be secondary to its effect on the release of parathyroid hormone from the parathyroid gland or an effect on vitamin D metabolism.
Regulation (effect) of Localization (release) of parathyroid hormone in parathyroid gland
7) Confidence 0.27 Published 1981 Journal J. Nutr. Section Abstract Doc Link 7310539 Disease Relevance 0.22 Pain Relevance 0.07
Primary hyperparathyroidism is a clinical condition related to an excessive and abnormally regulated secretion of parathyroid hormone (PTH) from the parathyroid glands which is responsible for an alteration of the calcium and phosphorus metabolism.
Regulation (regulated) of Localization (secretion) of PTH in parathyroid glands associated with hypercalcemia
8) Confidence 0.16 Published 2006 Journal Minerva Chir Section Abstract Doc Link 16568023 Disease Relevance 0.90 Pain Relevance 0.06
Estrogen regulates calcium metabolism, intestinal calcium absorption and parathyroid gene expression and secretion, triggering fluctuations across the menstrual cycle.
Regulation (regulates) of Localization (secretion) of parathyroid gene in parathyroid
9) Confidence 0.02 Published 2000 Journal J Am Coll Nutr Section Abstract Doc Link 10763903 Disease Relevance 0.72 Pain Relevance 0.28

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