INT40962

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Context Info
Confidence 0.80
First Reported 1982
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 40
Total Number 51
Disease Relevance 20.50
Pain Relevance 6.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
signal transducer activity (Avp)
Anatomy Link Frequency
neurohypophysis 4
pituitary 4
supraoptic nucleus 3
brain 3
paraventricular hypothalamic nucleus 2
Avp (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 5 99.90 Very High Very High Very High
medulla 121 99.76 Very High Very High Very High
depression 248 99.52 Very High Very High Very High
Enkephalin 3 99.02 Very High Very High Very High
Central nervous system 24 99.00 Very High Very High Very High
cytokine 158 98.90 Very High Very High Very High
Opioid 5 98.88 Very High Very High Very High
Morphine 19 98.38 Very High Very High Very High
antagonist 238 98.20 Very High Very High Very High
agonist 111 98.06 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 732 99.84 Very High Very High Very High
Stress 1433 99.82 Very High Very High Very High
Pressure Volume 2 Under Development 24 99.70 Very High Very High Very High
Targeted Disruption 862 99.62 Very High Very High Very High
Depression 272 99.52 Very High Very High Very High
Hypoglycemia 62 98.40 Very High Very High Very High
Pain 15 96.08 Very High Very High Very High
Hyponatremia 60 94.48 High High
Attention Deficit Hyperactivity Disorder 24 94.44 High High
Viral Meningitis 12 93.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several laboratories have reported that dynorphin and vasopressin may be present in the same neurons and released together in a fixed ratio.
Localization (released) of vasopressin in neurons associated with dynorphin
1) Confidence 0.80 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6129149 Disease Relevance 0 Pain Relevance 0.95
The release of arginine vasopressin (AVP) from the magnocellular neurosecretory cells (MNCs) in the supraoptic nucleus (SON) is crucial for body fluid homeostasis.
Localization (release) of arginine vasopressin in supraoptic nucleus
2) Confidence 0.78 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20089896 Disease Relevance 0 Pain Relevance 0
The release of arginine vasopressin (AVP) from the magnocellular neurosecretory cells (MNCs) in the supraoptic nucleus (SON) is crucial for body fluid homeostasis.
Localization (release) of AVP in supraoptic nucleus
3) Confidence 0.78 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20089896 Disease Relevance 0 Pain Relevance 0
The application of similar breeding strategies in two different species (Rattus norvegicus and Mus musculus) resulted in similar findings concerning the identification of polymorphisms in and around the Avp gene and both the expression and release patterns of AVP.
Localization (release) of Avp
4) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.72 Pain Relevance 0.08
Vibratome (Series 1000, Ted Pella Inc., Redding, CA) sections (50 µm) were preincubated in immunobuffer containing 5% normal donkey serum (Jackson ImmunoResearch, West Grove, PA) and then incubated for 48 h at room temperature with a polyclonal rabbit antibody to AVP (dilution 1?
Localization (dilution) of AVP
5) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.20 Pain Relevance 0
In contrast to strictly intermediate F1, NAB mice displayed in about 70% of all animals a HAB-like Avp expression and depression-like behavior in the tail-suspension test (Fig. 1B, D, E and [24]), which has also been demonstrated recently in an unselected CD1 population [59], thus further emphasizing the functional implications of centrally released AVP.
Localization (released) of AVP in tail associated with depression and anxiety disorder
6) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.87 Pain Relevance 0.10
Preclinical studies, including findings from the HAB/LAB rat model [18]–[21] and voles [22], as well as clinical observations [23] support a direct involvement of centrally released AVP in anxiety/depression-like behaviors and disorders.
Localization (released) of AVP associated with depression and anxiety disorder
7) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.90 Pain Relevance 0.11
In the present study, expression profiling in combination with qPCR and receptor autoradiography revealed no V1a/b-related difference between HAB and LAB mice in a variety of anxiety-associated brain regions, suggesting that line-specific divergences in behavior are primarily due to events upstream of the receptor, i.e. differential expression and release of AVP.
Localization (release) of AVP in brain associated with anxiety disorder
8) Confidence 0.70 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.75 Pain Relevance 0.08
Among the hypothetically discussed underlying mechanisms, one suggestion is that exogenous vasopressin interacts with an assumed discriminative stimulus function of endogenously released vasopressin.
Localization (released) of vasopressin
9) Confidence 0.70 Published 1984 Journal Behav. Brain Res. Section Abstract Doc Link 6539117 Disease Relevance 0 Pain Relevance 0.18
Plasma corticosterone (CORT), adrenocorticotropic hormone (ACTH), and estradiol (E2) levels were determined by RIA, whereas gene expression in brains, lymphoid organs, and skin was measured by quantitative RT-PCR for corticotropin-releasing hormone (Crh), arginine vasopressin (Avp), proopiomelanocortin (Pomc), glucocorticoid receptor (Nr3c1), mineralocorticoid receptor (Nr3c2), corticotropin-releasing hormone receptor types 1 and 2 (Crhr1, Crhr2), interleukin-12 (Il12), tumor necrosis factor-alpha (Tnf alpha), and estrogen receptors type-1 (Esr1) and type-2 (Esr2).
Localization (quantitative) of arginine vasopressin in skin associated with necrosis and cancer
10) Confidence 0.68 Published 2009 Journal J. Invest. Dermatol. Section Abstract Doc Link 19020552 Disease Relevance 0.88 Pain Relevance 0.09
In times of stress the hypothalamic-pituitary-adrenal (HPA) axis is activated and releases two neurohormones, corticotropin-releasing hormone (Crh) and arginine vasopressin (Avp), to synergistically stimulate the secretion of adrenocorticotropin hormone (ACTH) from the anterior pituitary, culminating in a rise in circulating glucocorticoids.
Localization (releases) of Avp in anterior pituitary associated with stress
11) Confidence 0.66 Published 2008 Journal Psychoneuroendocrinology Section Abstract Doc Link 18243568 Disease Relevance 0.25 Pain Relevance 0.19
Furthermore, we have assumed that the dynamics of stress-induced Avp, Crh and/or other ACTH secretagogue is similar in Avpr1b and wild-type mice.
Localization (secretagogue) of Avp associated with stress
12) Confidence 0.64 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.88 Pain Relevance 0
Moreover, studies of some specific acute stressors indicate that Avp may be preferentially released in favour of Crh (e.g. insulin-induced hypoglycaemia (IIH) in rats (Plotsky et al. 1985), ketamine anaesthesia and IIH in sheep (Engler et al. 1989)).
Localization (released) of Avp associated with hypoglycemia and ketamine
13) Confidence 0.64 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.80 Pain Relevance 0.08
Increased Avp secretion and enhanced pituitary responsiveness to Avp have been reported in some subtypes of depression (e.g. melancholic depression)(see, Dinan and Scott 2005 for a review).
Localization (secretion) of Avp in pituitary associated with depression
14) Confidence 0.64 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.29 Pain Relevance 0.26
As Oxt at high concentrations can elicit ACTH release via the Avpr1b, and the Oxtr may be expressed in corticotrophs, it has been suggested that increased expression of Oxtrs may be a compensatory mechanism through which Avpr1b KO mice and Brattleboro rats can, to some degree, make up for the lack of Avpr1b/Avp-mediated ACTH release (Nakamura et al. 2008).
Localization (release) of Avp-mediated in corticotrophs associated with targeted disruption
15) Confidence 0.64 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.62 Pain Relevance 0
The application of similar breeding strategies in two different species (Rattus norvegicus and Mus musculus) resulted in similar findings concerning the identification of polymorphisms in and around the Avp gene and both the expression and release patterns of AVP.
Localization (release) of AVP
16) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.72 Pain Relevance 0.08
Thus, the identification of polymorphisms in the Avp gene promoter explains gene expression differences in association with the observed phenotype, thus further strengthening the concept of the critical involvement of centrally released AVP in trait anxiety.



Localization (released) of AVP associated with anxiety disorder
17) Confidence 0.61 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2663030 Disease Relevance 0.42 Pain Relevance 0.04
Body fluid homeostasis requires the release of arginine-vasopressin (AVP, an antidiuretic hormone) from the neurohypophysis.
Localization (release) of AVP in neurohypophysis
18) Confidence 0.60 Published 2006 Journal Nat. Neurosci. Section Abstract Doc Link 16327782 Disease Relevance 0 Pain Relevance 0.06
Body fluid homeostasis requires the release of arginine-vasopressin (AVP, an antidiuretic hormone) from the neurohypophysis.
Localization (release) of arginine-vasopressin in neurohypophysis
19) Confidence 0.60 Published 2006 Journal Nat. Neurosci. Section Abstract Doc Link 16327782 Disease Relevance 0 Pain Relevance 0.06
Increased Avp secretion and enhanced pituitary responsiveness to Avp have been reported in some subtypes of depression (e.g. melancholic depression)(see, Dinan and Scott 2005 for a review).
Localization (secretion) of Avp in pituitary associated with depression
20) Confidence 0.59 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.31 Pain Relevance 0.26

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