INT4097

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Context Info
Confidence 0.81
First Reported 1976
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 66
Total Number 66
Disease Relevance 47.17
Pain Relevance 4.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pth) extracellular region (Pth) cellular_component (Pth)
Anatomy Link Frequency
parathyroid 37
parathyroid glands 4
thyroid 2
Autonomic 1
left lobe 1
Pth (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 5 99.56 Very High Very High Very High
Catecholamine 2 99.50 Very High Very High Very High
anesthesia 17 97.36 Very High Very High Very High
fibrosis 38 93.92 High High
Pain 71 91.76 High High
palliative 2 90.60 High High
imagery 44 90.00 High High
Analgesic 8 89.44 High High
Dismenorea 3 85.64 High High
depression 2 83.20 Quite High
Disease Link Frequency Relevance Heat
Parathyroid Cancer 81 99.96 Very High Very High Very High
Chronic Renal Failure 406 99.84 Very High Very High Very High
Hypocalcemia 36 99.82 Very High Very High Very High
Thymoma 48 99.68 Very High Very High Very High
Hypercalcemia 490 99.44 Very High Very High Very High
Cholangiocarcinoma 15 99.44 Very High Very High Very High
Metastasis 11 99.40 Very High Very High Very High
Acidosis 24 99.28 Very High Very High Very High
Bone Disease 11 99.16 Very High Very High Very High
Adenoma 3 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These effects were not correlated with anesthesia or immobilization, and we suggest that inaktin-induced changes in calcium metabolism involve an impairment of hypocalcemia-induced parathyroid hormone secretion, in addition to the impairment of parathyroid hormone effects previously reported.
Localization (secretion) of parathyroid hormone in parathyroid associated with hypocalcemia and anesthesia
1) Confidence 0.81 Published 1988 Journal Fundam Clin Pharmacol Section Abstract Doc Link 3402897 Disease Relevance 0.10 Pain Relevance 0.10
It is concluded that enkephalins do not influence the secretion and metabolism of the parathyroid hormone but block its peripheral effects and stimulate thyroid C-cell function.
Localization (secretion) of parathyroid hormone in thyroid associated with enkephalin
2) Confidence 0.81 Published 1985 Journal Probl Endokrinol (Mosk) Section Abstract Doc Link 3983100 Disease Relevance 0 Pain Relevance 0.17
We conclude that enkephalins do not influence the secretion and metabolism of the parathyroid hormone, but block its peripheral effects and stimulate thyroid C-cell function.
Localization (secretion) of parathyroid hormone in thyroid associated with enkephalin
3) Confidence 0.81 Published 1986 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 3025768 Disease Relevance 0 Pain Relevance 0.26
Evidence is presented to support the hypothesis that in subjects with parathyroid hyperactivity and Mg++ deficiency, the stimulus of a rise in serum ionic calcium (Ca++), and the resultant inhibition of parathyroid hormone (PTH) secretion, trigger the transfer of Ca++, Mg++ and other ions from the extracellular space into the exchangeable bone compartment.
Localization (secretion) of PTH in parathyroid associated with attention deficit hyperactivity disorder
4) Confidence 0.80 Published 1991 Journal Med. Hypotheses Section Abstract Doc Link 2056930 Disease Relevance 0.33 Pain Relevance 0.07
Evidence is presented to support the hypothesis that in subjects with parathyroid hyperactivity and Mg++ deficiency, the stimulus of a rise in serum ionic calcium (Ca++), and the resultant inhibition of parathyroid hormone (PTH) secretion, trigger the transfer of Ca++, Mg++ and other ions from the extracellular space into the exchangeable bone compartment.
Localization (secretion) of parathyroid hormone in parathyroid associated with attention deficit hyperactivity disorder
5) Confidence 0.80 Published 1991 Journal Med. Hypotheses Section Abstract Doc Link 2056930 Disease Relevance 0.34 Pain Relevance 0.07
Catecholamines are known stimulants of PTH secretion.
Localization (secretion) of PTH associated with catecholamine
6) Confidence 0.79 Published 2005 Journal Endocr. J. Section Abstract Doc Link 16410663 Disease Relevance 0.17 Pain Relevance 0.16
Autonomic and persistent hypersecretion of PTH is a frequent and tormenting complication of the patients with chronic renal dialysis for end stage renal disease (ESRD).
Localization (hypersecretion) of PTH in Autonomic associated with chronic renal failure and renal failure
7) Confidence 0.79 Published 2003 Journal Chirurgia (Bucur) Section Abstract Doc Link 14999960 Disease Relevance 0.57 Pain Relevance 0.03
Parathyroid hormone (PTH) is a straight-chain polypeptide secreted by the parathyroid gland that regulates calcium metabolism.
Localization (secreted) of PTH in Parathyroid
8) Confidence 0.78 Published 2010 Journal Med. Hypotheses Section Abstract Doc Link 19945800 Disease Relevance 0.17 Pain Relevance 0.07
Parathyroid hormone (PTH) is a straight-chain polypeptide secreted by the parathyroid gland that regulates calcium metabolism.
Localization (secreted) of Parathyroid hormone in Parathyroid
9) Confidence 0.78 Published 2010 Journal Med. Hypotheses Section Abstract Doc Link 19945800 Disease Relevance 0.17 Pain Relevance 0.07
Primary hyperparathyroidism is a fairly frequent pathologic diagnosis characterized by hypersecretion of parathyroid hormone, which results from adenomas in 80% to 85% of all cases.
Localization (hypersecretion) of parathyroid hormone in parathyroid associated with adenoma and hypercalcemia
10) Confidence 0.77 Published 2009 Journal J Craniofac Surg Section Abstract Doc Link 19884850 Disease Relevance 1.24 Pain Relevance 0.09
These findings suggested that benign parathyroid adenoma may mimic the clinical presentation of parathyroid carcinoma, releasing excess parathyroid hormone and resulting in hyperparathyroid crisis.
Localization (releasing) of parathyroid hormone in parathyroid associated with parathyroid cancer
11) Confidence 0.77 Published 2007 Journal J. Formos. Med. Assoc. Section Abstract Doc Link 17493890 Disease Relevance 1.25 Pain Relevance 0.08
The osteoblastic effect of inorganic phosphorus and the inhibitory action of calcium on parathyroid hormone secretion formed the basis for a therapeutic trial in which both elements were given intravenously in an alternating sequence for one year to five patients with severe osteoporosis.
Localization (secretion) of parathyroid hormone in parathyroid associated with osteoporosis
12) Confidence 0.77 Published 1976 Journal Am. J. Med. Section Abstract Doc Link 973642 Disease Relevance 0.39 Pain Relevance 0.06
One explanation might be that PTH secretion was lower after long-term cinacalcet therapy due to a reduction in the number of functional parathyroid cells (mass reduction).
Localization (secretion) of PTH in parathyroid
13) Confidence 0.76 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2644631 Disease Relevance 0.41 Pain Relevance 0
In response to the fall in serum calcium levels, PTH secretion increases as a compensatory mechanism to maintain mineral homeostasis.
Localization (secretion) of PTH
14) Confidence 0.75 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.45 Pain Relevance 0
Based on the evidence presented above, oral paricalcitol is able to effectively control PTH secretion in CKD patients when compared with placebo.
Localization (secretion) of PTH associated with chronic renal failure
15) Confidence 0.75 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.87 Pain Relevance 0
Vitamin D receptors are dispersed throughout the body in a number of tissues, and activation of these receptors may affect not only secretion of PTH but also modulation of the renin┬ľangiotensin system, left ventricular hypertrophy, and vascular calcification (Levin and Li 2005).
Localization (secretion) of PTH in body associated with calcification and left ventricular hypertrophy
16) Confidence 0.75 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936265 Disease Relevance 0.44 Pain Relevance 0.10
In two other rat studies, however, no influence of PTH on mineralization was found [2, 33].
Localization (mineralization) of PTH
17) Confidence 0.75 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2765647 Disease Relevance 0.13 Pain Relevance 0
Large vein sampling for intact parathyroid hormone in preoperative localization of enlarged parathyroid glands.
Localization (localization) of parathyroid hormone in parathyroid glands
18) Confidence 0.74 Published 1992 Journal Acta Radiol Section Title Doc Link 1449874 Disease Relevance 0.31 Pain Relevance 0.15
We conclude that EDTA treatment increases endogenous PTH secretion considerably and leads to increased bone resorption.
Localization (secretion) of PTH associated with hypercalcemia
19) Confidence 0.74 Published 1993 Journal Dan Med Bull Section Abstract Doc Link 8299406 Disease Relevance 0.31 Pain Relevance 0.06
MAIN OUTCOME MEASURES: Delay in surgical referral; improvement in symptoms and normalization of serum calcium and parathyroid hormone levels; and perioperative morbidity and mortality.
Localization (normalization) of parathyroid hormone in parathyroid
20) Confidence 0.72 Published 2003 Journal Arch Surg Section Body Doc Link 12912745 Disease Relevance 0.08 Pain Relevance 0

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