INT4103

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Context Info
Confidence 0.60
First Reported 1976
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 0.78
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (G6PD) small molecule metabolic process (G6PD) oxidoreductase activity (G6PD)
carbohydrate metabolic process (G6PD) lipid metabolic process (G6PD) cytoplasm (G6PD)
Anatomy Link Frequency
blood 1
hepatocytes 1
G6PD (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 99.40 Very High Very High Very High
Paracetamol 4 97.28 Very High Very High Very High
Analgesic 2 85.92 High High
Pain 2 54.32 Quite High
Codeine 1 25.00 Low Low
Morphine 1 25.00 Low Low
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sickle Cell Anemia 16 99.32 Very High Very High Very High
INFLAMMATION 3 77.52 Quite High
Stress 6 75.00 Quite High
Sepsis 2 53.60 Quite High
Toxicity 1 48.72 Quite Low
Sickle Cell Trait 2 21.48 Low Low
Malaria 8 15.64 Low Low
Overdose 3 5.00 Very Low Very Low Very Low
Leukemia 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hexokinase/glucose-6-phosphate dehydrogenase method (Boehringer Hexokinase method) is not affected by these substances.
Neg (not) Regulation (affected) of glucose-6-phosphate dehydrogenase
1) Confidence 0.60 Published 1976 Journal Clin. Chem. Section Abstract Doc Link 975521 Disease Relevance 0 Pain Relevance 0.35
DNA extracted from volunteering Danish blood donors were used as controls for wildtype HbAA and G6PD (B) (68VV/126NN).
Regulation (controls) of G6PD in blood
2) Confidence 0.45 Published 2005 Journal Malar J Section Body Doc Link PMC1326224 Disease Relevance 0 Pain Relevance 0
Effects of glucose-6-phosphate dehydrogenase deficiency upon sickle cell anemia.
Regulation (Effects) of glucose-6-phosphate dehydrogenase associated with sickle cell anemia
3) Confidence 0.29 Published 1988 Journal Blood Section Title Doc Link 3345344 Disease Relevance 0.55 Pain Relevance 0.05
We hypothesised then that G6PD is the target of carboxylic NSAIDs, via their CoA metabolites.
Regulation (target) of G6PD associated with cinod
4) Confidence 0.27 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17094951 Disease Relevance 0.23 Pain Relevance 0.33
In fact, estrogen-regulation of g6pd provides a likely explanation for differences we observed in hepatic g6pd expression between the sexes in this study (lower expression in females; data not shown), since female fish have higher circulating levels of endogenous estrogens than males.
Regulation (regulation) of g6pd
5) Confidence 0.20 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1802086 Disease Relevance 0 Pain Relevance 0
The down-regulation of hepatic ef1a and g6pd by EE2 observed in the present study also concurs with data from zebrafish embryos [39], where two ef1a isoforms were down-regulated by estrogen, and from the European flounder (Platichthys flesus), where E2 inhibited activity of the G6pd enzyme in hepatocytes by 30% in males and 80% in females [44].
Regulation (regulation) of g6pd in hepatocytes
6) Confidence 0.13 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1802086 Disease Relevance 0 Pain Relevance 0
In particular, ef1a, g6pd, bactin, and gapdh were found to be strongly regulated by estrogen, and this is consistent with data published for other teleosts.
Regulation (regulated) of g6pd
7) Confidence 0.09 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1802086 Disease Relevance 0 Pain Relevance 0
Glucose-6-phosphate dehydrogenase deficiency (G6PD) is the most common inherited enzymopathy affecting approximately 400 million people.
Regulation (affecting) of G6PD
8) Confidence 0.09 Published 1996 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 8911746 Disease Relevance 0 Pain Relevance 0.09

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