INT4104

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Context Info
Confidence 0.78
First Reported 1976
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 2.68
Pain Relevance 4.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (ADRB3) aging (ADRB3) plasma membrane (ADRB3)
nucleus (ADRB3) carbohydrate metabolic process (ADRB3) signal transducer activity (ADRB3)
Anatomy Link Frequency
myometrium 3
bladder 3
CHO 3
neurons 2
plasma 1
ADRB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 100 99.92 Very High Very High Very High
Mexiletine 24 99.76 Very High Very High Very High
lidocaine 9 98.56 Very High Very High Very High
agonist 290 98.44 Very High Very High Very High
Analgesic 4 94.08 High High
Somatostatin 8 89.12 High High
adenocard 13 84.36 Quite High
Calcium channel 20 84.12 Quite High
Catecholamine 1 80.24 Quite High
Angina 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Obesity 26 100.00 Very High Very High Very High
Overactive Bladder 73 99.06 Very High Very High Very High
Myocardial Infarction 4 98.68 Very High Very High Very High
Increased Venous Pressure Under Development 10 95.52 Very High Very High Very High
Stress 10 94.48 High High
Heart Rate Under Development 3 83.12 Quite High
Cv General 3 Under Development 3 75.00 Quite High
Stable Angina Pectoris 1 74.72 Quite High
Pre-term Labor 20 70.56 Quite High
Dysmenorrhea 10 62.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this paper the two key messages were as follows: (i) ADRB3 expression differs strongly between Human and Mouse myometrium and (ii) human ADRB3 is highly expressed in placenta, ovaries and myometrium (the relative level of expression being as follow: placenta = bladder > aorta > ovary > myometrium)
Gene_expression (expression) of ADRB3 in bladder
1) Confidence 0.78 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0 Pain Relevance 0.14
Indeed it has recently been suggested that ADRB3 are expressed in the endothelium of human coronary resistance arteries, or internal mammary arteries, and mediate adrenergic vasodilatation [18,19].
Gene_expression (expressed) of ADRB3 in internal associated with increased venous pressure under development
2) Confidence 0.78 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0.41 Pain Relevance 0.16
The presence of ADRB3 in human myometrium was confirmed in a work by Hakak et al. [36] who compared the ADRB3 expression in Human and mouse.
Gene_expression (expression) of ADRB3 in myometrium
3) Confidence 0.78 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0 Pain Relevance 0.11
We characterized the beta-adrenoceptor-blocking property of mexiletine, a class Ib antiarrhythmic drug, on Chinese hamster ovary (CHO) cells stably expressing cloned human beta1-, beta2-, and beta3-adrenoceptors.
Gene_expression (expressing) of beta3-adrenoceptor in CHO associated with mexiletine
4) Confidence 0.75 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15104234 Disease Relevance 0 Pain Relevance 0.28
In the light of our new results, we wanted to assess the influence of pregnancy on the function and the expression of the myometrial ADRB3-subtype [29].
Gene_expression (expression) of ADRB3
5) Confidence 0.68 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0 Pain Relevance 0.17
Binding competition studies, transcripts and protein analysis were then performed to determine whether any changes in the number of ADRB2 and ADRB3 binding sites and in the transcript and protein expression might explain the observed change in the contractile response between non-pregnant and pregnant myometrium to ADRB2 and ADRB3 agonists.
Gene_expression (expression) of ADRB3 in myometrium associated with agonist
6) Confidence 0.67 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0 Pain Relevance 0.07
The data suggest that the use of low and fixed doses of propranolol may not produce adequate plasma levels or significant beta-adrenoceptor blockade in the early stages of acute myocardial infarction in man.
Neg (not) Gene_expression (produce) of beta-adrenoceptor in plasma associated with myocardial infarction
7) Confidence 0.60 Published 1976 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 975619 Disease Relevance 0.64 Pain Relevance 0.22
Beta3-Adrenoceptor Agonists: Possible Role in the Treatment of Overactive Bladder

In the present review article, we present an overview of beta-adrenoceptor (?

Gene_expression (overview) of beta-adrenoceptor in Bladder associated with agonist and overactive bladder
8) Confidence 0.59 Published 2010 Journal Korean Journal of Urology Section Title Doc Link PMC3016425 Disease Relevance 0.76 Pain Relevance 0.27
The ADRB3 shares 40 to 50% amino acid sequence identity with ADRB1 and ADRB2.
Gene_expression (shares) of ADRB3
9) Confidence 0.59 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0.38 Pain Relevance 0.23
The ADRB3 is predominant over the ADRB2 and its expression is increased during pregnancy
Gene_expression (over) of ADRB3
10) Confidence 0.59 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0 Pain Relevance 0.25
The ADRB3 is predominant over the ADRB2 and its expression is increased during pregnancy
Gene_expression (predominant) of ADRB3
11) Confidence 0.59 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0 Pain Relevance 0.25
Lidocaine (10 and 100 microM and 1 mM) tend to reduce basal cAMP level on CHO cells stably expressing cloned human beta1-adrenoceptors, whereas the drug did not reduce the isoprenaline-induced cAMP accumulation on CHO cells stably expressing cloned human beta1-, beta2-, and beta3-adrenoceptors.
Gene_expression (expressing) of beta3-adrenoceptor in CHO associated with lidocaine
12) Confidence 0.58 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15104234 Disease Relevance 0 Pain Relevance 0.74
In this paper the two key messages were as follows: (i) ADRB3 expression differs strongly between Human and Mouse myometrium and (ii) human ADRB3 is highly expressed in placenta, ovaries and myometrium (the relative level of expression being as follow: placenta = bladder > aorta > ovary > myometrium)
Gene_expression (expressed) of ADRB3 in bladder
13) Confidence 0.53 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0 Pain Relevance 0.15
The ADRB3 is present and functional in human near term myometrium
Gene_expression (present) of ADRB3 in myometrium
14) Confidence 0.53 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0.28 Pain Relevance 0.15
BACKGROUND & AIMS: beta3 Adrenoceptor (beta3-AR) is expressed on adipocytes and enteric neurons.
Gene_expression (expressed) of beta3-AR in neurons associated with obesity
15) Confidence 0.53 Published 2010 Journal Gastroenterology Section Abstract Doc Link 19786030 Disease Relevance 0.10 Pain Relevance 0.26
BACKGROUND & AIMS: beta3 Adrenoceptor (beta3-AR) is expressed on adipocytes and enteric neurons.
Gene_expression (expressed) of beta3 Adrenoceptor in neurons associated with obesity
16) Confidence 0.53 Published 2010 Journal Gastroenterology Section Abstract Doc Link 19786030 Disease Relevance 0.10 Pain Relevance 0.26
Adipocytes expressed adiponectin, beta3-AR, and SST.
Gene_expression (expressed) of beta3-AR in Adipocytes
17) Confidence 0.53 Published 2010 Journal Gastroenterology Section Body Doc Link 19786030 Disease Relevance 0 Pain Relevance 0
Immunohistochemistry was used to detect adiponectin, beta3-AR, SST, SST2 receptors, tyrosine hydroxylase (TH), and protein gene product 9.5.
Gene_expression (receptors) of beta3-AR
18) Confidence 0.20 Published 2010 Journal Gastroenterology Section Body Doc Link 19786030 Disease Relevance 0 Pain Relevance 0
Characterization of mexiletine as an antagonist of beta-adrenoceptor in Chinese hamster ovary cells expressing cloned human beta-adrenoceptors.
Gene_expression (expressing) of beta-adrenoceptor in ovary associated with antagonist and mexiletine
19) Confidence 0.07 Published 2004 Journal Biochem. Pharmacol. Section Title Doc Link 15104234 Disease Relevance 0 Pain Relevance 0.42

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