INT4109

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Context Info
Confidence 0.81
First Reported 1976
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 5.57
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PGF) signal transduction (PGF) extracellular region (PGF)
cell-cell signaling (PGF)
Anatomy Link Frequency
endometrium 3
placenta 2
platelet 1
uterine 1
decidua 1
PGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 9 98.88 Very High Very High Very High
cINOD 2 90.80 High High
antagonist 3 85.68 High High
Inflammation 40 75.36 Quite High
cytokine 37 73.44 Quite High
aspirin 21 63.76 Quite High
fibrosis 2 19.60 Low Low
tolerance 2 13.72 Low Low
agonist 9 5.00 Very Low Very Low Very Low
Inflammatory marker 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 78 98.96 Very High Very High Very High
Dysmenorrhea 5 98.88 Very High Very High Very High
Pre-eclampsia 272 98.50 Very High Very High Very High
Diabetes Mellitus 49 94.96 High High
Hypertension 63 94.24 High High
Cancer 104 91.44 High High
INFLAMMATION 46 90.56 High High
Malignant Neoplastic Disease 6 87.80 High High
Body Weight 2 86.08 High High
Increased Venous Pressure Under Development 24 85.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Progesterone (1,000 ng/ml) markedly inhibited PGF secretion by proliferative but not secretory endometrium. 17 beta-estradiol and progesterone had no effect on prostaglandin E (PGE) secretion by both types of endometrium.
Localization (secretion) of PGF in endometrium
1) Confidence 0.81 Published 1982 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 7065034 Disease Relevance 0 Pain Relevance 0
Cyclooxygenase and PGF2?
Localization (Cyclooxygenase) of PGF
2) Confidence 0.73 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293427 Disease Relevance 0 Pain Relevance 0
Though the mechanism for PG cytoprotection is not fully elucidated, the concept of PGF-related buffering of BAK-induced toxicity may have implications for its use.62
Localization (related) of PGF associated with toxicity
3) Confidence 0.73 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2921296 Disease Relevance 0.66 Pain Relevance 0.07
These fluctuations correlate timedepending to the uterine contractions recorded and may be interpreted as a result of uterine PGF-release.
Localization (release) of PGF in uterine associated with dismenorea
4) Confidence 0.68 Published 1976 Journal Geburtshilfe Frauenheilkd Section Abstract Doc Link 976715 Disease Relevance 0.10 Pain Relevance 0.10
We concluded that the IUD did not cause continuous PG release and suggest that close contact of the IUD with the endometrium may prevent the endometrial cells from releasing PGF(2alpha).
Localization (releasing) of PGF in endometrium
5) Confidence 0.68 Published 2008 Journal Anim. Reprod. Sci. Section Abstract Doc Link 17643876 Disease Relevance 0.12 Pain Relevance 0.06
This was more apparent with PGF secretion and was detectable within the first 2 hours of culture.
Localization (secretion) of PGF
6) Confidence 0.62 Published 1982 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 7065034 Disease Relevance 0 Pain Relevance 0.08
Secretion of both PGF and PGE by proliferative and secretory endometria was inhibited by mefenamic acid ( 1 microgram/ml).
Localization (Secretion) of PGF
7) Confidence 0.62 Published 1982 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 7065034 Disease Relevance 0 Pain Relevance 0.06
Late proliferative (days 9 to 14) and midsecretory (days 18 to 24) human endometria were maintained in organ culture in the presence of 17 beta-estradiol and/or progesterone or mefenamic acid 17 beta-estradiol (0.1 to 1,000 ng/ml) increased prostaglandin F (PGF) secretion by both proliferative and secretory endometria.
Localization (secretion) of PGF
8) Confidence 0.62 Published 1982 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 7065034 Disease Relevance 0 Pain Relevance 0
Indomethacin had a greater effect than sulindac on the inhibition of collagen-induced platelet aggregation and thromboxane synthesis and the two drugs had equivalent effects on the reduction of PGF-M excretion.
Localization (excretion) of PGF-M in platelet
9) Confidence 0.61 Published 1985 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 4028619 Disease Relevance 0.31 Pain Relevance 0.09
In addition, atosiban suppresses OT-mediated release of PGE and PGF from the decidua.79,80

Phase II and III studies

Localization (release) of PGF in decidua
10) Confidence 0.24 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2861440 Disease Relevance 0.16 Pain Relevance 0.04
In conclusion, we have observed that the maternal concentration of the angiogenic factors sFlt1, sEng and PlGF are significantly higher among women with multifetal gestations compared with other high-risk groups including: pre-existing diabetes, chronic hypertension and previous preeclampsia.
Localization (sEng) of PlGF associated with diabetes mellitus, hypertension and pre-eclampsia
11) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952583 Disease Relevance 0.88 Pain Relevance 0.03
The odds for developing preeclampsia were significantly increased 2 to 3 fold for each 2-fold elevation in the concentration of sFlt1, sEng and the ratio of combined angiogenic factors (sFlt1+ sEng/PlGF) at study entry among women with multifetal gestations who later developed preeclampsia (Table 2).
Localization (concentration) of PlGF associated with pre-eclampsia
12) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952583 Disease Relevance 1.21 Pain Relevance 0.06
secreted by uNK cells from both non-pregnant <span style="background-color:#FFDEAD">endometrium</span> and early decidua [24].
Localization (secreted) of Placental Growth Factor in endometrium
13) Confidence 0.10 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.10
The VEGF-related gene family comprises six secreted glycoproteins: VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, placenta growth factor-1 and placenta growth factor-2 [91].
Localization (secreted) of placenta growth factor-2 in placenta
14) Confidence 0.08 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2972555 Disease Relevance 1.07 Pain Relevance 0
The VEGF-related gene family comprises six secreted glycoproteins: VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, placenta growth factor-1 and placenta growth factor-2 [91].
Localization (secreted) of placenta growth factor-1 in placenta
15) Confidence 0.08 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2972555 Disease Relevance 1.05 Pain Relevance 0

General Comments

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