INT41099

Context Info Confidence 0.64 First Reported 1983 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 2.38 Pain Relevance 2.89

cell differentiation (Mdk) extracellular region (Mdk)

Anatomy Link Frequency spinal 1 nodules 1 Mdk (Mus musculus)

Pain Link Frequency Relevance Heat Enkephalin 14 100.00 central sensitization 5 100.00 Thermal hyperalgesia 19 99.84 narcan 6 99.84 Somatostatin 5 96.80 Inflammation 30 95.64 electroacupuncture 2 95.48 intrathecal 6 94.68 Morphine 2 94.12 Arthritis 10 93.48

Disease Link Frequency Relevance Heat Hepatocellular Cancer 36 99.84 Hyperalgesia 21 99.84 Disease 9 96.44 INFLAMMATION 29 95.64 Autoimmune Disease 12 94.96 Arthritis 10 93.48 Cancer 76 89.92 Severe Combined Immunodeficiency 9 86.92 Rheumatoid Arthritis 5 81.20 Psoriasis 3 79.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Reduction of thermal hyperalgesia in the DN MEK mice is possibly due to decreased central sensitization since we showed clearly that spinal ERK activation following formalin injection was decreased in these mice.

Localization (sensitization) of DN MEK in spinal associated with central sensitization and thermal hyperalgesia

1) Confidence 0.64 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.65 Pain Relevance 0.76

The release of irDyn during electrostimulation at 5 Hz frequency was less active than irMEK release.

Localization (release) of irMEK

2) Confidence 0.55 Published 2005 Journal Bull. Exp. Biol. Med. Section Abstract Doc Link 16224585 Disease Relevance 0 Pain Relevance 0.22

In the present study, the more focal pattern of MEK-MAPK observed in HCC nodules may reflect local autocrine/paracrine signalling.

Localization (observed) of MEK in nodules associated with hepatocellular cancer

3) Confidence 0.26 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.76 Pain Relevance 0

NAL (10 microM) similarly counteracted the MEK (50 nM)-induced pertubations in islet hormone secretion.

Localization (secretion) of MEK associated with narcan and enkephalin

4) Confidence 0.24 Published 1983 Journal Endocrinology Section Abstract Doc Link 6135603 Disease Relevance 0 Pain Relevance 1.69

A number of drugs targeting the kinases p38, JNK, MEK, IKK2, JAK3, Lck, and Syk are currently undergoing clinical trials for the treatment of diseases related to inflammation and autoimmunity.

Localization (targeting) of MEK associated with autoimmune disease, inflammation and disease

5) Confidence 0.06 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.97 Pain Relevance 0.22

General Comments

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