INT41099

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Context Info
Confidence 0.64
First Reported 1983
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.38
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mdk) extracellular region (Mdk)
Anatomy Link Frequency
spinal 1
nodules 1
Mdk (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 14 100.00 Very High Very High Very High
central sensitization 5 100.00 Very High Very High Very High
Thermal hyperalgesia 19 99.84 Very High Very High Very High
narcan 6 99.84 Very High Very High Very High
Somatostatin 5 96.80 Very High Very High Very High
Inflammation 30 95.64 Very High Very High Very High
electroacupuncture 2 95.48 Very High Very High Very High
intrathecal 6 94.68 High High
Morphine 2 94.12 High High
Arthritis 10 93.48 High High
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 36 99.84 Very High Very High Very High
Hyperalgesia 21 99.84 Very High Very High Very High
Disease 9 96.44 Very High Very High Very High
INFLAMMATION 29 95.64 Very High Very High Very High
Autoimmune Disease 12 94.96 High High
Arthritis 10 93.48 High High
Cancer 76 89.92 High High
Severe Combined Immunodeficiency 9 86.92 High High
Rheumatoid Arthritis 5 81.20 Quite High
Psoriasis 3 79.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduction of thermal hyperalgesia in the DN MEK mice is possibly due to decreased central sensitization since we showed clearly that spinal ERK activation following formalin injection was decreased in these mice.
Localization (sensitization) of DN MEK in spinal associated with central sensitization and thermal hyperalgesia
1) Confidence 0.64 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.65 Pain Relevance 0.76
The release of irDyn during electrostimulation at 5 Hz frequency was less active than irMEK release.
Localization (release) of irMEK
2) Confidence 0.55 Published 2005 Journal Bull. Exp. Biol. Med. Section Abstract Doc Link 16224585 Disease Relevance 0 Pain Relevance 0.22
In the present study, the more focal pattern of MEK-MAPK observed in HCC nodules may reflect local autocrine/paracrine signalling.
Localization (observed) of MEK in nodules associated with hepatocellular cancer
3) Confidence 0.26 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.76 Pain Relevance 0
NAL (10 microM) similarly counteracted the MEK (50 nM)-induced pertubations in islet hormone secretion.
Localization (secretion) of MEK associated with narcan and enkephalin
4) Confidence 0.24 Published 1983 Journal Endocrinology Section Abstract Doc Link 6135603 Disease Relevance 0 Pain Relevance 1.69
A number of drugs targeting the kinases p38, JNK, MEK, IKK2, JAK3, Lck, and Syk are currently undergoing clinical trials for the treatment of diseases related to inflammation and autoimmunity.
Localization (targeting) of MEK associated with autoimmune disease, inflammation and disease
5) Confidence 0.06 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.97 Pain Relevance 0.22

General Comments

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