INT41108

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Context Info
Confidence 0.03
First Reported 1983
Last Reported 1983
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.81

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nucleoplasm (Adarb1) extracellular space (Ins1) extracellular region (Ins1)
mRNA processing (Adarb1) nucleolus (Adarb1) RNA binding (Adarb1)
Adarb1 (Rattus norvegicus)
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 1 100.00 Very High Very High Very High
Dynorphin 13 99.92 Very High Very High Very High
Somatostatin 4 93.14 High High
antagonist 2 62.20 Quite High
narcan 1 60.00 Quite High
Opioid receptor 1 1 59.16 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that (1) dynorphin is a very potent stimulus for insulin secretion; (2) dynorphin does not affect somatostatin secretion in static incubations of islets, in the same way as does glucose and glyceraldehyde; (3) dynorphin's effects may involve increased calcium ion movement and can be blocked by verapamil; (4) dynorphin can also increase islet c-AMP, and could thereby modulate the responsiveness of other secretagogues; (5) the actions of dynorphin on insulin secretion are not mediated by delta or mu opiate receptors in islets.
receptors Neg (not) Positive_regulation (mediated) of Localization (secretion) of insulin associated with dynorphin, somatostatin and opiate
1) Confidence 0.03 Published 1983 Journal Diabetes Section Abstract Doc Link 6135634 Disease Relevance 0 Pain Relevance 0.81

General Comments

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