INT41124

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 1983
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 3.17
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rb1) enzyme binding (Rb1) DNA binding (Rb1)
cell division (Rb1) transcription factor binding (Rb1)
Anatomy Link Frequency
spinal nerves 1
hearts 1
Rb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
noradrenaline 3 99.82 Very High Very High Very High
Brush evoked pain 4 99.16 Very High Very High Very High
Clonidine 1 97.92 Very High Very High Very High
agonist 49 97.52 Very High Very High Very High
antagonist 1 97.20 Very High Very High Very High
lidocaine 3 96.52 Very High Very High Very High
chung model 1 95.84 Very High Very High Very High
intrathecal 1 90.24 High High
Catecholamine 1 87.84 High High
anesthesia 9 80.08 Quite High
Disease Link Frequency Relevance Heat
Retinoblastoma 2 100.00 Very High Very High Very High
Neuropathic Pain 5 99.16 Very High Very High Very High
Cancer 45 96.80 Very High Very High Very High
Glioma 24 91.40 High High
Apoptosis 27 85.00 Quite High
Death 1 84.48 Quite High
Colon Cancer 4 84.36 Quite High
Infection 106 79.96 Quite High
Targeted Disruption 32 79.48 Quite High
Metastasis 1 77.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The noradrenaline-induced Rb+-efflux was effectively inhibited in the presence of prazosin, an alpha 1-blocker, whereas the alpha 2-antagonist, yohimbine, was roughly 50 times less potent.
Negative_regulation (inhibited) of Rb associated with antagonist and noradrenaline
1) Confidence 0.44 Published 1983 Journal Acta Physiol. Scand. Section Abstract Doc Link 6136155 Disease Relevance 0 Pain Relevance 0.42
Estradiol treatment the last 24 hrs before sacrifice decreased both PRAB and PRB levels significantly.
Negative_regulation (decreased) of PRB
2) Confidence 0.38 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.12 Pain Relevance 0
m) were used and a standard immunohistochemical technique (avidin-biotin-peroxidase) was utilized as described before [20], to visualize PRAB and PRB immunostaining intensity and distribution.
Negative_regulation (visualize) of PRB
3) Confidence 0.38 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0 Pain Relevance 0.08
In LE E2 and PPT treatments resulted in a major decrease of PRB immunostaining, from over 90% to below 20%, while DPN had no effect (Fig 5B,D,F,H; Fig 7 second panel).
Negative_regulation (decrease) of PRB
4) Confidence 0.33 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0 Pain Relevance 0.03
Dimethylamiloride (15 to 20 mumol/L), an inhibitor of the Na+/H+ exchanger, slightly reduced [Na+]i and Rb+ entry into the cardiomyocytes (by 15 +/- 5%). 31P NMR spectroscopy was used to monitor the energetic state and intracellular pH (pHi) in a parallel series of hearts.
Negative_regulation (reduced) of Rb in hearts
5) Confidence 0.33 Published 1995 Journal Circ. Res. Section Abstract Doc Link 7729001 Disease Relevance 0 Pain Relevance 0.25
Sulindac and sulindac sulfide decrease the levels of mitotic cyclins, induce the levels of p21WAF-1/cip1, and reduce the total levels of pRB, with a relative increase in the amount of the underphosphorylated form of pRB in a time- and concentration-dependent manner.
Negative_regulation (reduce) of pRB
6) Confidence 0.17 Published 1996 Journal Oncogene Section Abstract Doc Link 8632912 Disease Relevance 0.82 Pain Relevance 0.07
We found though, that DPN treatment caused down regulation of the PR protein level in GE, and indeed it also decreased the PRAB and PRB mRNA levels.
Negative_regulation (decreased) of PRB
7) Confidence 0.17 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.22 Pain Relevance 0
The Akt-mTOR-P70S6 kinase pathway is the central regulator of cell growth and proliferation, and increases cell proliferation by inhibiting the activities of p27Kip1 and retinoblastoma protein (RB).
Negative_regulation (inhibiting) of RB associated with retinoblastoma
8) Confidence 0.08 Published 2008 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2615285 Disease Relevance 0.31 Pain Relevance 0
The combination of decreased pRb in the absence of functional p16 may cause the cell to lose adequate control over the pRb pathway which is reinforced by the increase in cyclin D1 expression.
Negative_regulation (decreased) of pRb
9) Confidence 0.07 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.94 Pain Relevance 0
We investigated the effects of inhibiting spinal protein kinases including PKC, PKA and PKG on tactile allodynia in rats with a unilateral tight ligation on L5/L6 spinal nerves (Chung model).
Spec (investigated) Negative_regulation (inhibiting) of kinases including in spinal nerves associated with brush evoked pain and chung model
10) Confidence 0.01 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10624801 Disease Relevance 0.38 Pain Relevance 0.36
Using qRT-PCR, we found that AS 99 transcript abundances are reduced in both RB and IRB mosquitoes relative to S females (Figure 3E), though Ribeiro [15], also using transcript frequency analysis, found that both Trypsin 1 and Chymotrypsin 2 are up-regulated in whole adult female A. gambiae PBM.
Negative_regulation (reduced) of RB
11) Confidence 0.00 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1508153 Disease Relevance 0 Pain Relevance 0
S, RB and IRB cDNA libraries were constructed using the SMART™ cDNA Library Construction Kit (Clontech) from 1.54, 3.82 and 2.1?
Negative_regulation (libraries) of RB
12) Confidence 0.00 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1508153 Disease Relevance 0.38 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox