INT4122

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Context Info
Confidence 0.60
First Reported 1976
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.37
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PGC) extracellular space (PGC) extracellular region (PGC)
nucleolus (PGC) nucleus (PGC)
Anatomy Link Frequency
stomach 4
peptic cells 2
PGC (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 1 95.88 Very High Very High Very High
peptic ulcer disease 2 94.72 High High
cINOD 3 78.32 Quite High
qutenza 1 68.24 Quite High
substance P 1 49.04 Quite Low
Neuropeptide 1 45.56 Quite Low
Disease Link Frequency Relevance Heat
Duodenal Ulcer 3 100.00 Very High Very High Very High
Disease 3 100.00 Very High Very High Very High
Nicotine Addiction 1 96.94 Very High Very High Very High
Peptic Ulcer 1 96.34 Very High Very High Very High
Ulcers 4 94.40 High High
Infection 3 87.92 High High
Injury 3 76.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Effect of indomethacin on the secretion of pepsinogen in isolated human cells in vitro].
Regulation (Effect) of Localization (secretion) of pepsinogen
1) Confidence 0.60 Published 1996 Journal Rev Esp Enferm Dig Section Title Doc Link 9004795 Disease Relevance 0.06 Pain Relevance 0.06
The effects of indomethacin on pepsinogen secretion were studied in isolated human peptic cells prepared from endoscopically obtained biopsies after collagenase digestion, mechanical disruption and percoll gradient centrifugation.
Regulation (effects) of Localization (secretion) of pepsinogen in peptic cells
2) Confidence 0.52 Published 1996 Journal Rev Esp Enferm Dig Section Abstract Doc Link 9004795 Disease Relevance 0 Pain Relevance 0
Historically studies of pepsin over time have proved methodologically difficult, and as a result little work has been done on the effect of H. pylori on luminal pepsin secretion.
Regulation (effect) of Localization (secretion) of pepsin
3) Confidence 0.49 Published 2004 Journal Dig. Dis. Sci. Section Abstract Doc Link 15387329 Disease Relevance 0.52 Pain Relevance 0.09
Increase of pepsinogen secretion was dependent on extracellular calcium because potentiation was abolished by calcium depletion of the medium.
Regulation (dependent) of Localization (secretion) of pepsinogen
4) Confidence 0.26 Published 1996 Journal Rev Esp Enferm Dig Section Abstract Doc Link 9004795 Disease Relevance 0.08 Pain Relevance 0.08
1) In chronic gastric ulcer bed rest, leaving out smoking and carbenoxolone have increased the rate of healing. 2) In chronic duodenal ulcer it has yet to be shown that any medical measure so far significantly altered the course of the disease. 3) The surgical approach to the treatment of chronic duodenal ulcer is based upon three principles, all of them aiming at reducing the acid-pepsin secretion: a) Removal of the acid secreting mucosa decreases the acid secretory capacity of the stomach; b) Removal of the pyloric antrum eliminates the main source of gastrin, the major known humoral excitant of acid secretion; c) Section of the vagi probably renders the acid secreting cells less responsive to humoral stimulation (Brooks).
Regulation (altered) of Localization (secretion) of acid-pepsin in stomach associated with nicotine addiction, duodenal ulcer, disease and peptic ulcer
5) Confidence 0.01 Published 1976 Journal Klin. Wochenschr. Section Abstract Doc Link 979073 Disease Relevance 0.71 Pain Relevance 0.07
The importance of tachykinins for the regulation of pepsinogen and hormone secretion from the stomach remains unclear.
Regulation (regulation) of Localization (secretion) of pepsinogen and hormone in stomach
6) Confidence 0.01 Published 2000 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 11130458 Disease Relevance 0 Pain Relevance 0.12

General Comments

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