INT41250

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Context Info
Confidence 0.06
First Reported 1984
Last Reported 1984
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.40
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Adra2a, Eef1a1) signal transduction (Adra2a) nucleus (Eef1a1)
plasma membrane (Adra2a) translation (Eef1a1) GTPase activity (Eef1a1)
Adra2a (Rattus norvegicus)
Eef1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 6 99.58 Very High Very High Very High
addiction 1 95.96 Very High Very High Very High
antagonist 5 93.36 High High
Clonidine 1 62.20 Quite High
Potency 1 55.68 Quite High
Disease Link Frequency Relevance Heat
Hypotension 2 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 2 87.80 High High
Hypertension 1 56.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For the agonists, the central, alpha 2-adrenoceptor-elicited, hypotensive activity was not correlated with alpha 1-adrenoceptor binding affinity but was most significantly described in terms of affinity for alpha 2-adrenoceptors and a parabolic dependence on log P' (octanol/buffer; pH 7.4; 37 degrees C).
2-adrenoceptor-elicited Binding (affinity) of alpha 1 associated with addiction, hypotension and agonist
1) Confidence 0.06 Published 1984 Journal J. Med. Chem. Section Abstract Doc Link 6142954 Disease Relevance 0.40 Pain Relevance 0.56

General Comments

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