INT41296

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Context Info
Confidence 0.85
First Reported 1984
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 0.79
Pain Relevance 3.48

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plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Anatomy Link Frequency
adrenal medulla 1
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 17 100.00 Very High Very High Very High
Opioid 11 100.00 Very High Very High Very High
Dynorphin 2 100.00 Very High Very High Very High
Endogenous opioid 1 100.00 Very High Very High Very High
narcan 6 99.44 Very High Very High Very High
Immobilon 6 99.18 Very High Very High Very High
Enkephalin 5 97.60 Very High Very High Very High
medulla 1 95.56 Very High Very High Very High
Morphine 3 93.44 High High
agonist 7 92.80 High High
Disease Link Frequency Relevance Heat
Pain 2 87.04 High High
Charcot Marie Tooth Disease 1 81.08 Quite High
Neuroblastoma 1 79.00 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 75 64.56 Quite High
Myoclonus 1 59.60 Quite High
Convulsion 2 57.20 Quite High
Ataxia 1 55.84 Quite High
Paralysis 1 27.44 Quite Low
Infection 10 5.00 Very Low Very Low Very Low
Superinfection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this review, our knowledge on the molecular mechanisms of desensitization and recent progress on the role of opioid receptor internalization, recycling or degradation in desensitization will be reported.
Protein_catabolism (degradation) of opioid receptor associated with opioid receptor
1) Confidence 0.85 Published 2006 Journal Cell. Signal. Section Abstract Doc Link 16750901 Disease Relevance 0.16 Pain Relevance 0.81
The stability of the digitonin-soluble opioid receptor at room temperature makes it useful for purification and characterization.
Protein_catabolism (stability) of digitonin-soluble opioid receptor associated with opioid receptor
2) Confidence 0.43 Published 1984 Journal FEBS Lett. Section Abstract Doc Link 6144572 Disease Relevance 0 Pain Relevance 0.33
The fentanyl dose-response curve was unchanged by opioid receptor blockade with 10(-6)M naloxone and by alpha and beta adrenoceptor blockade produced by 10(-6)M prazosin and 10(-6)M propranolol.
Protein_catabolism (blockade) of opioid receptor associated with narcan and opioid receptor
3) Confidence 0.09 Published 1995 Journal Life Sci. Section Abstract Doc Link 8614244 Disease Relevance 0 Pain Relevance 0.51
The present study was designed to investigate the rate at which opioid receptor subtypes degrade postmortem.
Protein_catabolism (degrade) of opioid receptor associated with opioid receptor
4) Confidence 0.05 Published 1997 Journal Life Sci. Section Abstract Doc Link 9366506 Disease Relevance 0 Pain Relevance 0.25
The endogenous opioid peptide, dynorphin A (Dyn A) (1-17), is rapidly cleaved in vivo to the relatively more stable fragment Dyn A(2-17) which also produces excitatory behaviours in rodents via a non-opioid mechanism.
Protein_catabolism (cleaved) of opioid peptide associated with dynorphin, endogenous opioid and opioid
5) Confidence 0.04 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19580825 Disease Relevance 0.17 Pain Relevance 0.55
Sustained activation by peptides for 30 min caused a marked decrease of both [3H]diprenorphine binding sites and hDOR immunoreactivity, observed in a Western blot, whereas a moderate reduction by 30% was observed after a 30- and 60-min etorphine exposure in binding experiments without opioid receptor degradation.
Protein_catabolism (degradation) of opioid receptor associated with opioid receptor and immobilon
6) Confidence 0.02 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12672796 Disease Relevance 0.16 Pain Relevance 0.61
For example, sorting and lysosomal degradation of the Delta Opioid Receptor (DOR), a GPCR, is Hrs and Vps4 dependent but does not require TSG101 (ESCRT-I) [21].
Protein_catabolism (degradation) of Opioid Receptor associated with opioid
7) Confidence 0.01 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.29 Pain Relevance 0.10
Several peptide fragments are produced by proteolytic cleavage of the opioid peptide precursor proenkephalin A, and among these are a number of enkephalin fragments, in particular bovine adrenal medulla peptide 22 (BAM22).
Protein_catabolism (cleavage) of opioid peptide in adrenal medulla associated with medulla, enkephalin and opioid
8) Confidence 0.01 Published 2002 Journal Nat. Neurosci. Section Abstract Doc Link 11850634 Disease Relevance 0 Pain Relevance 0.33

General Comments

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