INT41313

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Context Info
Confidence 0.78
First Reported 1984
Last Reported 2010
Negated 0
Speculated 6
Reported most in Body
Documents 68
Total Number 74
Disease Relevance 34.24
Pain Relevance 11.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gpx1) mitochondrion (Gpx1) oxidoreductase activity (Gpx1)
nucleus (Gpx1) lipid metabolic process (Gpx1) cytoplasm (Gpx1)
Anatomy Link Frequency
liver 6
kidney 5
endometrium 4
blood 4
brain 3
Gpx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 2 100.00 Very High Very High Very High
Chronic pancreatitis 4 99.56 Very High Very High Very High
Inflammation 265 99.28 Very High Very High Very High
Visceral pain 28 99.20 Very High Very High Very High
Spinal cord 4 99.20 Very High Very High Very High
Neuropathic pain 2 98.64 Very High Very High Very High
fluoxetine 16 98.38 Very High Very High Very High
Paracetamol 38 98.32 Very High Very High Very High
cytokine 81 97.96 Very High Very High Very High
Pain score 4 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 6 100.00 Very High Very High Very High
Aids-related Complex 192 99.84 Very High Very High Very High
Diabetes Mellitus 667 99.68 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

32 99.60 Very High Very High Very High
Pancreatitis 8 99.56 Very High Very High Very High
Cancer 90 99.36 Very High Very High Very High
Insulin Resistance 60 99.34 Very High Very High Very High
Stress 865 99.28 Very High Very High Very High
INFLAMMATION 311 99.28 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

28 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data are accumulating to link alteration or abnormality of GPX1 expression to etiology of cancer, cardiovascular disease, neurodegeneration, autoimmune disease, and diabetes.
Gene_expression (expression) of GPX1 associated with autoimmune disease, diabetes mellitus, cardiovascular disease and cancer
1) Confidence 0.78 Published 2007 Journal Annu. Rev. Nutr. Section Abstract Doc Link 17465855 Disease Relevance 0.97 Pain Relevance 0.12
However, the GPX1-/- and DKO cells were more resistant to peroxynitrite-mediated protein nitration than were the WT cells.
Gene_expression (resistant) of GPX1
2) Confidence 0.67 Published 2006 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 16636302 Disease Relevance 0.48 Pain Relevance 0.74
OBJECTIVE: To determine the expression of glutathione peroxidase (GPx) in the eutopic and ectopic endometria during the menstrual cycle in endometriosis and adenomyosis.
Spec (determine) Gene_expression (expression) of GPx associated with endometriosis and dismenorea
3) Confidence 0.67 Published 2000 Journal Fertil. Steril. Section Abstract Doc Link 10927050 Disease Relevance 0.34 Pain Relevance 0.26
On the other hand, the expression of GPx1 (cytosolic GPx) is highly responsive to Se status.
Gene_expression (expression) of GPx1
4) Confidence 0.54 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.06 Pain Relevance 0
RESULT(S): The analyses revealed phase-dependent changes of GPx expression in the surface and glandular epithelia in the eutopic endometrium during the menstrual cycle in the fertile controls, i.e., the expression was weak in the early proliferative phase, gradually increased, was most marked in the early secretory phase, and decreased thereafter.
Gene_expression (expression) of GPx in endometrium
5) Confidence 0.52 Published 2000 Journal Fertil. Steril. Section Body Doc Link 10927050 Disease Relevance 0.15 Pain Relevance 0
The expression of GPx in the eutopic endometrium in endometriosis lost the variation during the menstrual cycle.
Gene_expression (expression) of GPx in endometrium
6) Confidence 0.52 Published 2000 Journal Fertil. Steril. Section Body Doc Link 10927050 Disease Relevance 0.13 Pain Relevance 0
CONCLUSION(S): The aberrant expression of GPx in the eutopic endometrium throughout the cycle suggests a pathological role in endometriosis and adenomyosis.


Gene_expression (expression) of GPx in endometrium
7) Confidence 0.52 Published 2000 Journal Fertil. Steril. Section Body Doc Link 10927050 Disease Relevance 0.11 Pain Relevance 0
The expression of GPx in adenomyosis was persistently marked over the control levels throughout the menstrual cycle.
Gene_expression (expression) of GPx
8) Confidence 0.52 Published 2000 Journal Fertil. Steril. Section Body Doc Link 10927050 Disease Relevance 0.12 Pain Relevance 0
In order to investigate the anti-inflammatory mechanism of MKGS, we analyzed the activities of glutathione peroxidase (GPx) and glutathione reductase (GRx) in the liver, and the levels of interleukin-1beta (IL-1beta), tumor necrosis factor (TNF-alpha), malondialdehyde (MDA) and nitric oxide (NO) in the edema paw tissue.
Spec (analyzed) Gene_expression (activities) of GPx in MKGS associated with pressure and volume under development, necrosis, inflammation and cancer
9) Confidence 0.48 Published 2010 Journal Am. J. Chin. Med. Section Abstract Doc Link 20503470 Disease Relevance 0.78 Pain Relevance 0.46
GPx2 (gastrointestinal GPx) and GPx5 (sperm nuclei GPx) have tissue specific localization, while the expression of GPx3 (extracellular GPx) was found to be extremely low in mouse brain 41.
Gene_expression (expression) of GPx in brain
10) Confidence 0.47 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.13 Pain Relevance 0
On the other hand, the expression of GPx1 (cytosolic GPx) is highly responsive to Se status.
Gene_expression (expression) of GPx
11) Confidence 0.47 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.06 Pain Relevance 0
The enzymes directly scavenging ROS included glutathione peroxidase 1 (GPx1, also a selenoenzyme), catalase (Cat), superoxide dismutases 1 and 2 (SOD1, SOD2); phase II enzymes included glutamylcysteine synthetase heavy chain and light chain (GCS-HC, GCS-LC); glutathione S-transferase omega 1 and alpha 2 (GSTo1, GSTa2), and heme oxygenase-1 (HO-1); selenoproteins thioredoxin reductases 1 (TR1), and selenoprotein H (SelH) were also investigated.
Spec (investigated) Gene_expression (included) of GPx1
12) Confidence 0.47 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0 Pain Relevance 0
The enzymes directly scavenging ROS included glutathione peroxidase 1 (GPx1, also a selenoenzyme), catalase (Cat), superoxide dismutases 1 and 2 (SOD1, SOD2); phase II enzymes included glutamylcysteine synthetase heavy chain and light chain (GCS-HC, GCS-LC); glutathione S-transferase omega 1 and alpha 2 (GSTo1, GSTa2), and heme oxygenase-1 (HO-1); selenoproteins thioredoxin reductases 1 (TR1), and selenoprotein H (SelH) were also investigated.
Spec (investigated) Gene_expression (included) of glutathione peroxidase 1
13) Confidence 0.47 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0 Pain Relevance 0
The cell lysate was centrifuged for 10 min at 10,000 x g, the supernatant was collected for GSH and GPx assays.
Gene_expression (assays) of GPx
14) Confidence 0.47 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0 Pain Relevance 0.03
The impact of these compounds on mRNA expression of GPX, TNF-alpha, and MCP-1 indicated that these compounds could act at a transcription level.
Gene_expression (expression) of GPX
15) Confidence 0.46 Published 2009 Journal J. Food Sci. Section Abstract Doc Link 19799668 Disease Relevance 0.44 Pain Relevance 0.58
Unexpectedly, the expression of the enzymes that directly scavenge ROS decreased, including superoxide dismutases 1 and 2, glutathione peroxidase 1, and catalase.
Gene_expression (expression) of glutathione peroxidase 1
16) Confidence 0.42 Published 2007 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC1925139 Disease Relevance 0.09 Pain Relevance 0
Therefore, the increased GPx activity after Se supplementation observed in this study is most likely attributable to GPx1, as potentially counteracts the downregulation of GPx1 expression by long-term Rot treatment.

5.

Gene_expression (expression) of GPx1
17) Confidence 0.42 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.07 Pain Relevance 0
Figure 3 indicates that the ability of direct scavenging Rot-induced ROS may be compromised in HT22 cells since the expression of the enzymes that dismutate superoxide (SOD1, SOD2) or reduce hydrogen peroxide (GPx1, catalase) was decreased following the Rot treatment.
Gene_expression (expression) of GPx1
18) Confidence 0.42 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.12 Pain Relevance 0
-glutamyl transpeptidase, GPX glutathione peroxidase, GR glutathione reductase, GST glutathione-S-transferase, GSSG glutathione disulfideFigure 3Heat shock protein 70 protein levels in kidney tissues from Ames dwarf and wild-type mice at 3, 12, and 24 months of age.
Gene_expression (glutathione peroxidase) of GPX in kidney associated with shock
19) Confidence 0.41 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.51 Pain Relevance 0
GPx2 (gastrointestinal GPx) and GPx5 (sperm nuclei GPx) have tissue specific localization, while the expression of GPx3 (extracellular GPx) was found to be extremely low in mouse brain 41.
Gene_expression (expression) of GPx in brain
20) Confidence 0.41 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1925139 Disease Relevance 0.19 Pain Relevance 0

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