INT41315

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Context Info
Confidence 0.66
First Reported 1984
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.78
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
dendrites 1
muscle 1
Fbxo23 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
GABAergic 2 99.60 Very High Very High Very High
Potency 3 97.82 Very High Very High Very High
gABA 9 96.68 Very High Very High Very High
Neurotransmitter 4 96.06 Very High Very High Very High
tetrodotoxin 1 92.56 High High
Fibrositis 1 92.12 High High
withdrawal 8 87.24 High High
alcohol 56 86.80 High High
Hippocampus 1 81.20 Quite High
Central nervous system 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Sleep Disorders 7 92.12 High High
Alcohol Addiction 7 87.24 High High
Toxicity 7 66.48 Quite High
Overdose 10 60.48 Quite High
Poisoning 1 57.92 Quite High
Drug Dependence 59 57.12 Quite High
Convulsion 5 50.32 Quite High
Coma 2 16.40 Low Low
Nicotine Addiction 17 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GHB is accumulated by the vesicular inhibitory aminoacid transporter (VIAAT) and released by depolarization via a Ca2+ dependent-mechanism.
Localization (released) of GHB
1) Confidence 0.66 Published 2005 Journal Med Sci (Paris) Section Abstract Doc Link 15745703 Disease Relevance 0.27 Pain Relevance 0.43
gamma-Hydroxybutyrate (GHB) fulfills the main criteria of a neurotransmitter: it is unevenly distributed in C.N.S.; it is synthesized from succinic semi-aldehyde by a specific semi-aldehyde succinic reductase localized in neurons, in some dendrites and synaptic terminals; GHB is released by tissue slice depolarization, this release being reduced by 50-60% in a Ca++ free medium.
Localization (released) of GHB in dendrites associated with neurotransmitter
2) Confidence 0.43 Published 1984 Journal C. R. Acad. Sci. III, Sci. Vie Section Abstract Doc Link 6145513 Disease Relevance 0 Pain Relevance 0.32
Despite its use for this purpose a recent literature review produced no empirical evidence that GHB-induced hormone release yielded any increase in muscle mass.
Localization (release) of GHB in muscle
3) Confidence 0.06 Published 2004 Journal Harm Reduct J Section Body Doc Link PMC419978 Disease Relevance 0.39 Pain Relevance 0.21
The high potency of luteolin for inhibiting GHB uptake suggested that this compound may be effective at increasing the renal clearance of GHB.
Localization (clearance) of GHB associated with potency
4) Confidence 0.03 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0.13 Pain Relevance 0.05

General Comments

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