INT4133

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Context Info
Confidence 0.47
First Reported 1976
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 17
Disease Relevance 8.24
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Npc1) nuclear envelope (Npc1) Golgi apparatus (Npc1)
endoplasmic reticulum (Npc1) plasma membrane (Npc1) lysosome (Npc1)
Anatomy Link Frequency
plasma 1
liver 1
nerve cell 1
heart 1
Npc1 (Mus musculus)
Pain Link Frequency Relevance Heat
local anesthetic 2 98.04 Very High Very High Very High
Inflammation 12 83.24 Quite High
opiate 2 75.00 Quite High
narcan 1 61.52 Quite High
fibrosis 6 59.32 Quite High
agonist 1 50.08 Quite High
anesthesia 7 50.00 Quite Low
thoracic epidural anesthesia 2 50.00 Quite Low
cytokine 6 24.72 Low Low
imagery 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 343 100.00 Very High Very High Very High
Nicotine Addiction 120 99.76 Very High Very High Very High
Atherosclerosis 48 99.32 Very High Very High Very High
Liver Disease 9 98.68 Very High Very High Very High
Coronary Artery Disease 168 98.60 Very High Very High Very High
Hydrops Fetalis 9 95.04 Very High Very High Very High
Pressure And Volume Under Development 3 93.20 High High
Jaundice 21 87.28 High High
Diabetes Mellitus 36 83.84 Quite High
INFLAMMATION 19 83.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of cholesterol to NPC1 and dissociation both appear accelerated by NPC2 [83].
NPC1 Binding (Binding) of
1) Confidence 0.47 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0 Pain Relevance 0
The mature native NPC1 is a large (1252 amino acids) glycoprotein with 13 transmembrane domains, that resides primarily in late endosomes and interacts transiently with lysosomes and the trans-Golgi network [54,80].
NPC1 Binding (interacts) of
2) Confidence 0.37 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0.47 Pain Relevance 0
Interaction of functional NPC1 gene Polymorphism with smoking on coronary heart disease

Background

NPC1 Binding (Interaction) of in heart associated with coronary artery disease and nicotine addiction
3) Confidence 0.36 Published 2010 Journal BMC Med Genet Section Title Doc Link PMC2966454 Disease Relevance 0.95 Pain Relevance 0
NPC1 ploymorphism interact with smoking on coronary atherosclerosis
NPC1 Binding (interact) of associated with nicotine addiction and atherosclerosis
4) Confidence 0.36 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 1.80 Pain Relevance 0
Using four-by-two table to estimate additive interaction between +644A/G and cigarette smoking, we found no interaction between NPC1 genotype and cigarette smoking on risk for CHD (Table 5).


NPC1 Neg (no) Binding (interaction) of associated with coronary artery disease and nicotine addiction
5) Confidence 0.36 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 1.93 Pain Relevance 0
Furthermore in multiplicative interaction mode, there was a significant interaction between NPC1 +644A > G and cigarette smoking on risk for CHD.
NPC1 Binding (interaction) of associated with coronary artery disease and nicotine addiction
6) Confidence 0.33 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 1.34 Pain Relevance 0
Niemann-Pick C disease is now recognized as a relatively common cause of liver disease in early life.
Niemann-Pick Binding (recognized) of in liver associated with liver disease and disease
7) Confidence 0.31 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 1.00 Pain Relevance 0
Of the three primary sub-cellular fractions derived from mouse brain homogenates, the P3 (microsomal) fraction binds 3H-di-hydromorphine stereo-specifically with the highest capacity per mg. of protein; this level is nearly as great as that bound by purified synaptosomal plasma membranes (SPM).
SPM Binding (bound) of in plasma
8) Confidence 0.30 Published 1976 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 981782 Disease Relevance 0 Pain Relevance 0.13
As the amount of pDNA of the D-SPM/pDNA complex was 13.5??
D-SPM/pDNA Binding (complex) of
9) Confidence 0.13 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896664 Disease Relevance 0 Pain Relevance 0
Accumulation of the aggregates of D-SPM/pDNA and serum protein could entrap the pDNA inside the complex by impeding the disassociation of the pDNA from the D-SPM, after its uptake into the cells' cytoplasm.
D-SPM/pDNA Binding (aggregates) of
10) Confidence 0.13 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896664 Disease Relevance 0.24 Pain Relevance 0.03
The weight-mixing ratio of D-SPM/pDNA was fixed to 16, and the amount of pDNA administered was varied from 9.5??
D-SPM/pDNA Binding (ratio) of
11) Confidence 0.13 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896664 Disease Relevance 0 Pain Relevance 0
Accumulation of the aggregates of D-SPM/pDNA and serum protein could entrap the pDNA inside the complex by impeding the disassociation of the pDNA from the D-SPM, after its uptake into the cells' cytoplasm.
D-SPM Binding (disassociation) of
12) Confidence 0.13 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896664 Disease Relevance 0.22 Pain Relevance 0.03
We also showed that the D-SPM/pDNA complex was formed within a nanometer range.
D-SPM/pDNA Binding (complex) of
13) Confidence 0.12 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896664 Disease Relevance 0 Pain Relevance 0
In addition, we also evaluated the size of the D-SPM/pDNA particle complex and its pDNA protection efficiency against a nuclease.

2.

D-SPM/pDNA Binding (complex) of
14) Confidence 0.12 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896664 Disease Relevance 0.15 Pain Relevance 0.04
We investigated modulations of lipid dynamics and lipid-protein interactions of rat brain synaptosomal plasma membrane (SPM) as one of the possible mechanisms by which the local anesthetic bupivacaine (BPV) has an adverse effect on nerve cell function, with SPM-bound enzyme activity used as a functional probe.
SPM Binding (interactions) of in nerve cell associated with local anesthetic
15) Confidence 0.07 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9390604 Disease Relevance 0.07 Pain Relevance 0.10
Eight patients underwent TEA, and 9 underwent LCSD (3 patients had both procedures).
LCSD Binding (underwent) of
16) Confidence 0.06 Published 2010 Journal Circulation Section Body Doc Link 20479150 Disease Relevance 0.08 Pain Relevance 0
The use of PENTO and SPM is not associated with hyperglycemia.
SPM Binding (associated) of
17) Confidence 0.01 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18165568 Disease Relevance 0 Pain Relevance 0

General Comments

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