INT4134

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Context Info
Confidence 0.58
First Reported 1975
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 2.97
Pain Relevance 4.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Glce)
Anatomy Link Frequency
liver 1
Glce (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 47 99.84 Very High Very High Very High
qutenza 20 99.00 Very High Very High Very High
aspirin 7 97.52 Very High Very High Very High
Analgesic 10 95.20 Very High Very High Very High
adenocard 2 62.16 Quite High
Disease Link Frequency Relevance Heat
Crigler-najjar Syndrome 4 100.00 Very High Very High Very High
Toxicity 8 99.52 Very High Very High Very High
Sprains And Strains 3 99.44 Very High Very High Very High
Necrosis 14 98.96 Very High Very High Very High
Hyperbilirubinemia 3 98.92 Very High Very High Very High
Overdose 2 98.76 Very High Very High Very High
Jaundice 1 97.96 Very High Very High Very High
Hepatotoxicity 6 86.56 High High
Death 1 86.20 High High
Nephrotoxicity 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Homozygous members of the mutant Gunn strain of Wistar rats suffer an inherited autosomal recessive deficiency of glucuronyl transferase resulting in unconjugated hyperbilirubinaemia and jaundice.
Negative_regulation (deficiency) of glucuronyl transferase associated with hyperbilirubinemia, jaundice and sprains and strains
1) Confidence 0.58 Published 1976 Journal J. Pathol. Section Abstract Doc Link 1003268 Disease Relevance 0.60 Pain Relevance 0
Studies in the rat given an overdose of the drug showed that within 24 hours there was a striking reduction in the activity of bilirubin glucuronyl-transferase and the content of cytochrome P.450 in the liver.
Negative_regulation (reduction) of glucuronyl-transferase in liver associated with overdose
2) Confidence 0.51 Published 1976 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 981967 Disease Relevance 0.27 Pain Relevance 0.26
Homozygous Gunn rats, mutant Wistars genetically lacking glucuronyl transferase, develop renal papillary necrosis after single oral doses of aspirin and of phenacetin.
Negative_regulation (lacking) of glucuronyl transferase associated with aspirin and necrosis
3) Confidence 0.43 Published 1976 Journal J. Pathol. Section Abstract Doc Link 1003266 Disease Relevance 0.25 Pain Relevance 0.29
Fasting did not depress the level of the enzyme, glucuronyl transferase, or the basal level of the co-substrate, UDP-glucuronic acid (UDPGA).
Neg (not) Negative_regulation (depress) of glucuronyl transferase
4) Confidence 0.33 Published 1988 Journal Biochem. Pharmacol. Section Abstract Doc Link 3128294 Disease Relevance 0 Pain Relevance 0.37
Homozygous members of the mutant Gunn strain of Wistar rats genetically lack the enzyme uridine diphosphate glucuronyl transferase.
Negative_regulation (lack) of glucuronyl transferase associated with sprains and strains
5) Confidence 0.21 Published 1975 Journal Br J Exp Pathol Section Abstract Doc Link 1203171 Disease Relevance 0.38 Pain Relevance 0.47
Homozygous and heterozygous Gunn rats are, respectively, severely and moderately deficient in glucuronyl transferase.
Negative_regulation (deficient) of glucuronyl transferase
6) Confidence 0.16 Published 1989 Journal Hepatology Section Abstract Doc Link 2501210 Disease Relevance 0.24 Pain Relevance 0.38
A genetic deficiency in bilirubin UDP-glucuronyl transferase may predispose humans and animals to the toxicity of drugs that are extensively glucuronidated, if other glucuronyl transferase isoenzymes are concurrently deficient.
Negative_regulation (deficiency) of glucuronyl transferase associated with toxicity
7) Confidence 0.14 Published 1989 Journal Hepatology Section Abstract Doc Link 2501210 Disease Relevance 0.25 Pain Relevance 0.25
A genetic deficiency in bilirubin UDP-glucuronyl transferase may predispose humans and animals to the toxicity of drugs that are extensively glucuronidated, if other glucuronyl transferase isoenzymes are concurrently deficient.
Negative_regulation (deficient) of glucuronyl transferase associated with toxicity
8) Confidence 0.12 Published 1989 Journal Hepatology Section Abstract Doc Link 2501210 Disease Relevance 0.25 Pain Relevance 0.31
Enhanced acetaminophen toxicity in rats with bilirubin glucuronyl transferase deficiency.
Negative_regulation (deficiency) of glucuronyl transferase associated with toxicity, paracetamol and crigler-najjar syndrome
9) Confidence 0.12 Published 1989 Journal Hepatology Section Title Doc Link 2501210 Disease Relevance 0.29 Pain Relevance 0.45
Uridine dinucleotide phosphate (UDP)-glucuronyl transferase activity was decreased by dietary piperine and the combination of curcumin and capsaicin.
Negative_regulation (decreased) of glucuronyl transferase associated with qutenza
10) Confidence 0.11 Published 2006 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 17487234 Disease Relevance 0 Pain Relevance 0.43
Hepatic microsomal glucuronyl transferase activity was significantly decreased in vitro by addition of capsaicin or piperine.
Negative_regulation (decreased) of glucuronyl transferase associated with qutenza
11) Confidence 0.10 Published 2006 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 17487234 Disease Relevance 0 Pain Relevance 0.61
However remarkably little impairment of several enzyme systems in microsome, such as cytochrome P450 content, arylhydrocarbon hydroxylase and glucuronyl transferase has been reported (Thorgeirsson et al., 1976, Chiu and Bhakthan, 1978: Willson and Hart, 1977, Yamada et al., 1981).
Negative_regulation (impairment) of glucuronyl transferase
12) Confidence 0.05 Published 1983 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 6665301 Disease Relevance 0.44 Pain Relevance 0.48

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