INT41340

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Context Info
Confidence 0.47
First Reported 1984
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.76
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Htr1a) plasma membrane (Htr1a) signal transducer activity (Htr1a)
Anatomy Link Frequency
brain 1
Htr1a (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 28 100.00 Very High Very High Very High
Eae 50 99.32 Very High Very High Very High
Dopamine 7 99.20 Very High Very High Very High
5HT 18 99.10 Very High Very High Very High
adenocard 13 98.80 Very High Very High Very High
antidepressant 100 98.30 Very High Very High Very High
antagonist 78 97.76 Very High Very High Very High
fluoxetine 3 93.48 High High
Clonidine 9 93.44 High High
Potency 1 88.80 High High
Disease Link Frequency Relevance Heat
Neuroblastoma 1 96.92 Very High Very High Very High
Aggression 6 88.24 High High
Psychosis 1 87.76 High High
Anxiety Disorder 4 80.00 Quite High
Hypothermia 5 59.60 Quite High
Depression 18 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 5 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 3 5.00 Very Low Very Low Very Low
Thinness 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, the results indicate that the antidepressant-like effect of adenosine in the FST appears to be mediated, at least in part, by an interaction with 5-HT1A receptors.
5-HT1A Binding (interaction) of associated with adenocard and antidepressant
1) Confidence 0.47 Published 2005 Journal Brain Res. Bull. Section Abstract Doc Link 16140163 Disease Relevance 0 Pain Relevance 0.91
2-adrenoceptor and low affinity for the imidazoline sites, but this compound also binds to the 5-HT1A, 5HT1B, 5-HT1D and dopamine D2 sites [14].
5-HT1A Binding (binds) of associated with dopamine
2) Confidence 0.47 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2572591 Disease Relevance 0.06 Pain Relevance 0.65
The antiaggressive effect correlates with 5-HT1A receptor affinity in vitro and with generalization to the 8-OHDPAT-induced discriminative stimulus.
5-HT1A Binding (affinity) of
3) Confidence 0.36 Published 1993 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7870899 Disease Relevance 0.32 Pain Relevance 0.62
On the other hand, our locomotor activity results suggest the existence of interaction between group II mGlu receptors and serotonin 5HT1A and 5HT2A receptors.
5HT1A Binding (interaction) of associated with eae and serotonin
4) Confidence 0.35 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0.29 Pain Relevance 0.64
Cultured NCB-20 mouse neuroblastoma X Chinese hamster brain clonal hybrid cells express an adenylate cyclase-coupled receptor for serotonin (5HT) which corresponds pharmacologically to the 5HT1 receptor in whole brain, except for its much lower affinity for serotonin.
5HT1 receptor Neg (except) Binding (affinity) of in brain associated with neuroblastoma, 5ht and serotonin
5) Confidence 0.02 Published 1984 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 6146253 Disease Relevance 0.10 Pain Relevance 0.34

General Comments

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