INT41358

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Context Info
Confidence 0.79
First Reported 1981
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 6.06
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pf4) extracellular region (Pf4) protein complex assembly (Pf4)
molecular_function (Pf4) protein complex (Pf4)
Anatomy Link Frequency
platelet 9
plasma 1
coronary artery 1
Pf4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 16 100.00 Very High Very High Very High
headache 16 99.80 Very High Very High Very High
Restless leg syndrome 1 94.60 High High
aspirin 6 94.32 High High
Angina 20 93.36 High High
ischemia 2 82.12 Quite High
cva 26 73.04 Quite High
Catecholamine 2 70.48 Quite High
antagonist 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache 12 99.80 Very High Very High Very High
Coronary Artery Disease 10 98.64 Very High Very High Very High
Increased Venous Pressure Under Development 5 94.60 High High
Heparin-induced Thrombocytopenia 200 94.12 High High
Cv General 3 Under Development 29 93.36 High High
Attention Deficit Hyperactivity Disorder 2 92.92 High High
Atherosclerosis 1 92.84 High High
Peripheral Arterial Disease 5 91.52 High High
Stress 6 90.44 High High
Cerebrovascular Disease 1 87.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Platelet factor 4 release during exercise in patients with coronary artery disease.
Localization (release) of Platelet factor 4 in coronary artery associated with coronary artery disease
1) Confidence 0.79 Published 1984 Journal Am. J. Hematol. Section Title Doc Link 6147087 Disease Relevance 0.54 Pain Relevance 0.13
Platelet aggregation was normal in TH, but the secretion of serotonin and platelet factor 4 (PF4) was significantly increased in response to 0.5 and 2.0 micrograms/ml collagen and to 1.0 mumol/l PAF.
Localization (secretion) of PF4 in Platelet associated with headache and serotonin
2) Confidence 0.77 Published 1993 Journal Cephalalgia Section Abstract Doc Link 8242729 Disease Relevance 0.36 Pain Relevance 0.72
Platelet aggregation was normal in TH, but the secretion of serotonin and platelet factor 4 (PF4) was significantly increased in response to 0.5 and 2.0 micrograms/ml collagen and to 1.0 mumol/l PAF.
Localization (secretion) of platelet factor 4 in Platelet associated with headache and serotonin
3) Confidence 0.77 Published 1993 Journal Cephalalgia Section Abstract Doc Link 8242729 Disease Relevance 0.36 Pain Relevance 0.72
We used a recently described radioimmunoassay for the platelet-secreted protein platelet factor 4 (PF4) to study 162 patients with documented coronary artery disease.
Localization (secreted) of PF4 in platelet associated with coronary artery disease
4) Confidence 0.65 Published 1981 Journal Circulation Section Abstract Doc Link 6973419 Disease Relevance 0.63 Pain Relevance 0.06
The platelet release proteins, beta-thromboglobulin (BTG) and platelet factor 4 (PF4), were markedly elevated in the first 2 days and dropped gradually thereafter.
Localization (release) of PF4 in platelet
5) Confidence 0.25 Published 1994 Journal Int. J. Cardiol. Section Abstract Doc Link 8181885 Disease Relevance 0.42 Pain Relevance 0.35
The platelet release proteins, beta-thromboglobulin (BTG) and platelet factor 4 (PF4), were markedly elevated in the first 2 days and dropped gradually thereafter.
Localization (release) of platelet factor 4 in platelet
6) Confidence 0.25 Published 1994 Journal Int. J. Cardiol. Section Abstract Doc Link 8181885 Disease Relevance 0.42 Pain Relevance 0.35
We have compared prospectively four tests for the measurement of in vivo platelet activation (plasma betaTG, plasma PF4, intraplatelet betaTG and urinary excretion of 11-dehydro-TXB2) and one in vitro platelet function test (ADP-induced platelet aggregation) in 63 well-characterized patients with intermittent claudication and in 18 age- and sex-matched healthy volunteers.
Localization (excretion) of PF4 in plasma associated with restless leg syndrome
7) Confidence 0.19 Published 1997 Journal Thromb. Haemost. Section Abstract Doc Link 9423790 Disease Relevance 0.59 Pain Relevance 0.09
Platelet function was assessed by filtragometry ex vivo (reflecting platelet aggregability), by measuring platelet secretion (beta-thromboglobulin and platelet factor 4 levels in plasma), and by Born aggregometry in vitro.
Localization (secretion) of platelet factor 4 in Platelet
8) Confidence 0.14 Published 1997 Journal Eur. Heart J. Section Abstract Doc Link 9152651 Disease Relevance 0.72 Pain Relevance 0.38
When platelets are activated, PF4 is released into the circulation and some of it binds to the platelet surface.
Localization (released) of PF4 in platelets
9) Confidence 0.14 Published 2005 Journal Thromb J Section Body Doc Link PMC1262784 Disease Relevance 0.44 Pain Relevance 0
Activated platelets on the one hand release PF4, thus causing increased formation of antigen/antibody complexes, and on the other hand cause the massive activation of thrombin, which is the most potent intrinsic activator of platelets.
Localization (release) of PF4 in platelets
10) Confidence 0.12 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721302 Disease Relevance 1.07 Pain Relevance 0.10
Activated platelets release PF4, thus perpetuating the cycle of heparin-induced platelet activation.
Localization (release) of PF4 in platelet
11) Confidence 0.12 Published 2005 Journal Thromb J Section Body Doc Link PMC1262784 Disease Relevance 0.50 Pain Relevance 0

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