INT41359

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Context Info
Confidence 0.46
First Reported 1984
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 3.32
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Atp2b4)
Anatomy Link Frequency
plasma 2
nerve 1
D-M 1
reticulum 1
Atp2b4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
halothane 15 99.58 Very High Very High Very High
isoflurane 14 98.34 Very High Very High Very High
tetrodotoxin 2 93.56 High High
lidocaine 1 87.64 High High
local anesthetic 2 86.80 High High
midbrain 1 84.68 Quite High
Potency 1 82.96 Quite High
Pain 4 80.40 Quite High
Bile 6 55.92 Quite High
anesthesia 1 55.44 Quite High
Disease Link Frequency Relevance Heat
Disease 2 99.82 Very High Very High Very High
Diabetes Mellitus 12 97.92 Very High Very High Very High
Apoptosis 110 96.04 Very High Very High Very High
Aging 7 87.16 High High
Sprains And Strains 6 86.32 High High
Obesity 11 85.20 High High
Pain 4 80.40 Quite High
Disorder Of Lipid Metabolism 6 80.32 Quite High
Injury 12 73.88 Quite High
Hepatotoxicity 52 66.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclopiazonic acid (10 microM), a specific inhibitor of endoplasmic reticulum Ca(2+) ATPases, reversibly abolished the events.
Negative_regulation (inhibitor) of ATPases in reticulum
1) Confidence 0.46 Published 2000 Journal J. Neurophysiol. Section Abstract Doc Link 10634866 Disease Relevance 0 Pain Relevance 0.14
A wide spectrum of structurally disparate inhalational anesthetics reduce brain synaptic plasma membrane Ca(2+)-ATPase (PMCA) activity, whereas phospholipid methyltransferase I (PLMTI) is enhanced by anesthetics.
Negative_regulation (reduce) of PMCA in plasma
2) Confidence 0.40 Published 1996 Journal Life Sci. Section Abstract Doc Link 8890928 Disease Relevance 0.24 Pain Relevance 0.13
Pyrethroid insecticides have been reported to increase transmembrane sodium influx and inhibit ion-dependent ATPases in insect, squid, and toad nerve tissues.
Negative_regulation (inhibit) of ATPases in nerve
3) Confidence 0.37 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6327330 Disease Relevance 0 Pain Relevance 0
Several rat models with incidental or disease-induced reduction of PMCA and enhancement of PLMTI activities manifest increased sensitivity to inhalational anesthetics.
Negative_regulation (reduction) of PMCA associated with disease
4) Confidence 0.26 Published 1996 Journal Life Sci. Section Abstract Doc Link 8890928 Disease Relevance 0.38 Pain Relevance 0.20
For F344/BNF1 rats, MED for halothane was reduced to 87%, PMCA activity was diminished to 90% in cortical SPM and 72% DM SPM, and PLMTI activity was increased to 133% in cortical SPM and 112% in DM SPM.
Negative_regulation (diminished) of PMCA associated with halothane
5) Confidence 0.17 Published 1996 Journal Life Sci. Section Abstract Doc Link 8890927 Disease Relevance 0.34 Pain Relevance 0.32
For aged Fisher-344 rats, MEDs for halothane, desflurane, isoflurane and xenon were reduced to 81%, 82%, 67% and 86%, respectively, of young controls; PMCA activity was diminished to 91% in cortical SPM and 82% in DM SPM; and cortical and DM PLMTI activities were increased to 131% and 114% of young control.
Negative_regulation (diminished) of PMCA associated with isoflurane and halothane
6) Confidence 0.17 Published 1996 Journal Life Sci. Section Abstract Doc Link 8890927 Disease Relevance 0.38 Pain Relevance 0.34
Cerebral and D-M PMCA activities were each reduced to about 90% of control values 2 weeks after STZ induction.
Negative_regulation (reduced) of PMCA in D-M
7) Confidence 0.16 Published 1995 Journal Life Sci. Section Abstract Doc Link 7752806 Disease Relevance 0.82 Pain Relevance 0.29
CsA-induced peroxidation of membrane lipids was coupled with significant inhibition of membrane ATPases.
Negative_regulation (inhibition) of ATPases
8) Confidence 0.10 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2291455 Disease Relevance 0.21 Pain Relevance 0.03
Approximately the same concentrations of each agent gave 50% inhibition of both ATPases, for example 7.9 and 10 mM tetracaine for Mg2+-ATPase and (Na+ + K+)-ATPase, respectively; these concentrations are 10-fold higher than required for inhibition of mitochondrial F1-ATPase.
Negative_regulation (inhibition) of ATPases
9) Confidence 0.09 Published 1984 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6147163 Disease Relevance 0 Pain Relevance 0.29
In the present study, reduction in the activities of ATPases in CsA administered rats may be due to the oxidation of membrane lipids and proteins.
Negative_regulation (reduction) of ATPases
10) Confidence 0.07 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2291455 Disease Relevance 0.31 Pain Relevance 0.03
An alternative mechanism of action could be the inhibition by vanadate of several ATPases, including both plasma and endoplasmic reticulum membrane Ca-ATPases and plasma membrane NaK-ATPases (Ortiz et al. 1984, Garrahan & Rega 1988), although there are no reports of this having anti-apoptotic effects.
Negative_regulation (inhibition) of ATPases in plasma associated with apoptosis
11) Confidence 0.01 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.64 Pain Relevance 0

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