INT4137

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Context Info
Confidence 0.69
First Reported 1976
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 73
Total Number 75
Disease Relevance 48.57
Pain Relevance 12.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
skin 2
liver 2
jejunum 2
plasma 1
canal 1
C3 (Homo sapiens)
Pain Link Frequency Relevance Heat
analgesia 4 99.98 Very High Very High Very High
Pain 30 99.84 Very High Very High Very High
Morphine 20 99.84 Very High Very High Very High
Inflammation 228 99.78 Very High Very High Very High
Angina 29 99.52 Very High Very High Very High
anesthesia 20 99.42 Very High Very High Very High
spinal inflammation 27 99.24 Very High Very High Very High
ischemia 122 99.22 Very High Very High Very High
cytokine 52 98.98 Very High Very High Very High
Migraine 11 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 591 99.96 Very High Very High Very High
Thrombocytopenia 103 99.96 Very High Very High Very High
Pain 26 99.84 Very High Very High Very High
Acute Coronary Syndrome 9 99.84 Very High Very High Very High
INFLAMMATION 309 99.78 Very High Very High Very High
Apoptosis 89 99.78 Very High Very High Very High
Hemolytic Uremic Syndrome 35 99.60 Very High Very High Very High
Cv General 3 Under Development 48 99.52 Very High Very High Very High
Nose Bleeds 1 99.50 Very High Very High Very High
Flavivirus Infection 960 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mean maximum level of sensory analgesia increased from T6 (group 1), to T5 (group 2) and T3 (group 3), with an absolute maximum level of C3 (statistically not significant).
Positive_regulation (increased) of C3 associated with analgesia
1) Confidence 0.69 Published 1990 Journal Reg Anaesth Section Abstract Doc Link 2356345 Disease Relevance 0 Pain Relevance 0.49
Only a slight increase in C3 was observed after spinal anesthesia.
Positive_regulation (increase) of C3 in spinal associated with anesthesia
2) Confidence 0.68 Published 1976 Journal Ann Anesthesiol Fr Section Abstract Doc Link 984516 Disease Relevance 0 Pain Relevance 0.45
On laboratory examination, serum IgM, C3, and C4 were mildly elevated.
Positive_regulation (elevated) of C3
3) Confidence 0.62 Published 1990 Journal Rinsho Shinkeigaku Section Abstract Doc Link 2279359 Disease Relevance 0.80 Pain Relevance 0.18
In keeping with the above results, jejunum tissue specimens showed no increase in the presence of activated C3 over the course of IR, when compared to their healthy controls (Fig. 6B.
Positive_regulation (activated) of C3 in jejunum
4) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.25 Pain Relevance 0.07
The lack of activated complement components as well as a clear increase in local C3 mRNA expression levels may illustrate the intestines response aimed at protection and preservation.
Spec (clear) Positive_regulation (increase) of C3 mRNA in intestines
5) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.33 Pain Relevance 0.08
This result suggests that the activation of the (C4b2b) C3 convertase was not mediated by differences on the levels of immune complexes in DF and DHF patients.
Positive_regulation (activation) of C3 associated with flavivirus infection and dengue
6) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.45 Pain Relevance 0
There was a significant rise in C5b-9 membrane attack complex (P =.0012) with a corresponding fall in C3 (P =.0013) and C4 (P =.0002) levels and a rise in C3 degradation product levels (P =.0006).
Positive_regulation (rise) of C3
7) Confidence 0.45 Published 2004 Journal Liver Transpl. Section Abstract Doc Link 14762866 Disease Relevance 0 Pain Relevance 0.12
Dilution alone cannot explain the fall in C3 and C4 levels as there is a corresponding increase in membrane attack complex and C3 degradation product levels with time.
Positive_regulation (increase) of C3
8) Confidence 0.45 Published 2004 Journal Liver Transpl. Section Abstract Doc Link 14762866 Disease Relevance 0 Pain Relevance 0.09
Dilution alone cannot explain the fall in C3 and C4 levels as there is a corresponding increase in membrane attack complex and C3 degradation product levels with time.
Positive_regulation (increase) of C3
9) Confidence 0.45 Published 2004 Journal Liver Transpl. Section Abstract Doc Link 14762866 Disease Relevance 0 Pain Relevance 0.09
The in vitro antioxidant activity, evaluated in human epithelial or transformed neoplastic keratinocyte cells, HaCaT, and normal dermal fibroblasts in terms of cell survival following ultraviolet B (UVB) irradiation, was significantly increased in the presence of Cu2(asp)4, Cu(sal)2, and CuSO4.
Positive_regulation (increased) of asp in fibroblasts
10) Confidence 0.45 Published 2005 Journal J. Biol. Inorg. Chem. Section Abstract Doc Link 16261369 Disease Relevance 0.19 Pain Relevance 0.16
Pregnancy can be associated with laboratory changes, including increases in ESR and C3, and classical complement activation with decreased C4, which complicate disease assessment[11].
Positive_regulation (increases) of C3 associated with disease
11) Confidence 0.37 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2860355 Disease Relevance 1.40 Pain Relevance 0
Laboratory evaluation showed hemolytic anemia with fragmentation, thrombocytopenia, elevated lactic dehydrogenase level, low haptoglobin level, low complement C3 level, and elevated antistreptolysin-O titer.
Positive_regulation (elevated) of C3 associated with hemolytic anemia and thrombocytopenia
12) Confidence 0.37 Published 2005 Journal Am. J. Kidney Dis. Section Abstract Doc Link 16183409 Disease Relevance 1.57 Pain Relevance 0.09
Myelography and computerized tomography of the cervical spine performed under general anesthesia demonstrated only a minimal rotation of C3 with respect to C4 and a rather narrow cervical canal.
Positive_regulation (rotation) of C3 in canal associated with anesthesia
13) Confidence 0.37 Published 1982 Journal Childs Brain Section Abstract Doc Link 7128247 Disease Relevance 0.67 Pain Relevance 0.26
No significant differences for the elevated C3 and C4 levels at the 1st day were observed between the two diseases groups (AMI1 vs AP1 --> C3: p = 0.879, C4: p = 0.818).
Positive_regulation (elevated) of C3 associated with disease
14) Confidence 0.37 Published 2007 Journal Bangladesh Med Res Counc Bull Section Abstract Doc Link 18783065 Disease Relevance 0.41 Pain Relevance 0.16
At the 7th day, C3 and C4 levels were further elevated in AMI, while they remained at the similar elevated levels in AP (C3 --> AMI 7: 173.1 +/- 28.0, AP 7: 149.0 +/- 41.0, CS: 132.0 +/- 8.0, ANOVA: p = 0.0000; C4 --> AMI 7: 46.0 +/- 7.0, AP 7: 36.0 +/- 15.0, CS: 29.0 +/- 6.0, ANOVA: p = 0.0000).
Positive_regulation (elevated) of C3
15) Confidence 0.37 Published 2007 Journal Bangladesh Med Res Counc Bull Section Abstract Doc Link 18783065 Disease Relevance 0.40 Pain Relevance 0.15
In our model no deposition of activated C3 in reperfused jejunum was detected, using immunohistochemical and Western blot analysis.
Neg (no) Positive_regulation (activated) of C3 in jejunum
16) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737143 Disease Relevance 0.44 Pain Relevance 0.12
In order to determine whether the lower levels of C3 were indeed the result of high levels of complement system activity during infection, the C3 levels of the DHF patients were also measured during the convalescent phase (Figure 1B).
Spec (whether) Positive_regulation (levels) of C3 associated with flavivirus infection and infection
17) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.26 Pain Relevance 0
0.005) increase in the C3 levels of the DHF patients after they recovered from the acute infection, and these levels were not significantly different from the levels found in control patients, confirming that the C3 was consumed at higher levels in DHF patients than in DF patients during the acute stage of the dengue infection.
Positive_regulation (consumed) of C3 associated with flavivirus infection, dengue and infection
18) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.63 Pain Relevance 0
These results suggest the presence of an increased availability of the C3bBb C3 convertase in DHF patients that may be responsible for the higher consumption of C3 and increased production of C3a and C5a in these patients.
Positive_regulation (consumption) of C3 associated with flavivirus infection
19) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.02 Pain Relevance 0
During the convalescent phase, the mean factor D levels in the DF patients returned to that of DHF patients and control subjects (Figure 5B), suggesting that the levels of factor D in DF patients were reduced during acute dengue infection, limiting the rate of conversion of the C3bBB into the active C3 convertase, C3bBb, in these patients.
Positive_regulation (active) of C3 associated with flavivirus infection, dengue and infection
20) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.68 Pain Relevance 0

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