INT41381

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Context Info
Confidence 0.44
First Reported 1984
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.29
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plg) extracellular space (Plg) extracellular region (Plg)
Anatomy Link Frequency
retina 2
liver 2
skin 2
uterine 2
lung 2
Plg (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 13 100.00 Very High Very High Very High
analgesia 4 100.00 Very High Very High Very High
agonist 20 99.98 Very High Very High Very High
tolerance 4 83.84 Quite High
addiction 7 75.00 Quite High
Inflammation 8 68.56 Quite High
narcan 3 68.40 Quite High
withdrawal 2 67.04 Quite High
opioid receptor 4 25.00 Low Low
antagonist 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 174 99.68 Very High Very High Very High
Bullous Skin Disease 304 98.96 Very High Very High Very High
Targeted Disruption 7 98.56 Very High Very High Very High
Melanoma 17 96.96 Very High Very High Very High
Lewis Lung Carcinoma 1 96.44 Very High Very High Very High
Diabetes Mellitus 72 96.12 Very High Very High Very High
Metastasis 15 94.68 High High
Acantholysis 65 93.96 High High
Adhesions 56 90.92 High High
Toxicity 6 79.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prolyl-leucyl-glycinamide (PLG) at a low dose (10 ng/mouse) administered intracerebroventricularly (i.c.v.) did not affect morphine analgesia, but produced a greater increase in the ED50 of morphine-pretreated (100 mg/kg of morphine sulfate) mice as compared to control mice.
Positive_regulation (increase) of Gene_expression (produced) of PLG associated with analgesia and morphine
1) Confidence 0.44 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6148243 Disease Relevance 0.20 Pain Relevance 1.21
AAV-mediated stable expression of angiostatin slowed tumor growth and prolonged survival in the highly aggressive B16F10 melanoma and Lewis lung carcinoma models of experimental metastasis.
Positive_regulation (mediated) of Gene_expression (expression) of angiostatin in lung associated with melanoma, cancer, lewis lung carcinoma and metastasis
2) Confidence 0.26 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 1.04 Pain Relevance 0
The rAAV-angiostatin injections led to sustained angiostatin gene expression in retina as confirmed by RT-PCR, and reduced extravascular albumin accumulation in STZ-induced diabetic retina.
Positive_regulation (led) of Gene_expression (expression) of angiostatin in retina associated with diabetes mellitus
3) Confidence 0.19 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2533034 Disease Relevance 0.45 Pain Relevance 0
The expression of plasminogen mRNA from hepatocyte is dependent on the cell density and stimulation [47] and is solely expressed in liver.
Positive_regulation (dependent) of Gene_expression (expression) of plasminogen mRNA in liver
4) Confidence 0.09 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0.15 Pain Relevance 0.03
Moreover, plasminogen activator activity and expression of the urokinase-type plasminogen activator receptor (uPAR) system were found to be increased following treatment with PV- and PF-IgG/serum in keratinocytes in vitro as well as in PV patientsÂ’ skin (Feliciani et al. 2003; Hashimoto et al. 1983; Lo Muzio et al. 2002; Schaefer et al. 1996; Seishima et al. 1997; Yamamoto et al. 2007b), possibly via phospholipase C (PLC)-mediated signalling (Esaki et al. 1995).
Positive_regulation (increased) of Gene_expression (expression) of plasminogen in skin associated with bullous skin disease
5) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.35 Pain Relevance 0
These results do not exclude PLA2G4A from playing a role in oxytocin-stimulated uterine PG production.
Positive_regulation (stimulated) of Gene_expression (production) of PG in uterine
6) Confidence 0.02 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1868772 Disease Relevance 0.10 Pain Relevance 0
In contrast, non-specific PLA2 inhibitors significantly diminished both basal and agonist-induced PG production [10-12].
Positive_regulation (induced) of Gene_expression (production) of PG associated with agonist
7) Confidence 0.02 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1868772 Disease Relevance 0 Pain Relevance 0.05
Cells overexpressing PLA2G6 produced similar quantities of the two PGs and these values were significantly higher than PG production by non-transfected cells.
Positive_regulation (higher) of Gene_expression (production) of PG
8) Confidence 0.02 Published 2007 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1868772 Disease Relevance 0 Pain Relevance 0

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