INT41394

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Context Info
Confidence 0.43
First Reported 1984
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.78
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gclc) ligase activity (Gclc)
Gclc (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 1 92.72 High High
Paracetamol 11 84.88 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 8 92.76 High High
Death 2 87.84 High High
Targeted Disruption 8 85.92 High High
Toxicity 3 82.64 Quite High
Stress 6 79.84 Quite High
Necrosis 2 64.00 Quite High
Stupor 1 57.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At these doses maximum effects on gamma-GCS and GSH were observed 2-4 hr after BSO administration; initial gamma-GCS activity and GSH content were restored approximately 16 hr post BSO.
Regulation (effects) of gamma-GCS
1) Confidence 0.43 Published 1984 Journal Biochem. Pharmacol. Section Abstract Doc Link 6148944 Disease Relevance 0.06 Pain Relevance 0
Two factors important in its detoxification are UDP-glucuronosyltransferase (UDP-GT), an ARE-regulated phase-II drug-metabolizing enzyme, and glutathione (GSH), an antioxidant molecule whose synthesis depends on ARE-regulated gamma-glutamylcysteine synthetase (gammaGCS).
Regulation (regulated) of gamma-glutamylcysteine synthetase
2) Confidence 0.39 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11134556 Disease Relevance 0.64 Pain Relevance 0.16
The down-regulation of GCLC in RXRalpha-deficient mice led to 40% and 45% reductions in the rate of glutathione (GSH) synthesis and level of hepatic GSH, respectively.
Regulation (regulation) of GCLC
3) Confidence 0.26 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 14978233 Disease Relevance 0.15 Pain Relevance 0.25
Interestingly, the effects on gamma-GCS varied markedly according to the compound: BSO and DEM increased gamma-GCS enzyme activity, although only DEM, but not BSO, resulted in an increase in gamma-GCS(h) mRNA and protein.
Regulation (effects) of gamma-GCS
4) Confidence 0.23 Published 2000 Journal Hepatology Section Abstract Doc Link 10915739 Disease Relevance 0.29 Pain Relevance 0.07
Two factors important in its detoxification are UDP-glucuronosyltransferase (UDP-GT), an ARE-regulated phase-II drug-metabolizing enzyme, and glutathione (GSH), an antioxidant molecule whose synthesis depends on ARE-regulated gamma-glutamylcysteine synthetase (gammaGCS).
Regulation (regulated) of gammaGCS
5) Confidence 0.17 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11134556 Disease Relevance 0.65 Pain Relevance 0.16

General Comments

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