INT41395

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Context Info
Confidence 0.61
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 1.34
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gclc) ligase activity (Gclc)
Gclc (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 3 100.00 Very High Very High Very High
Paracetamol 37 99.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 42 99.70 Very High Very High Very High
Hepatotoxicity 4 89.72 High High
Toxicity 6 70.60 Quite High
Stupor 1 66.32 Quite High
Cancer 6 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low
Chronic Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BB significantly increased both HO-1 and GCLC protein at this time point, CCl4 increased GCLC protein alone, although FS did not alter either of these proteins.
Positive_regulation (increased) of GCLC
1) Confidence 0.61 Published 2008 Journal Toxicology Section Abstract Doc Link 18078705 Disease Relevance 0.06 Pain Relevance 0.38
Interestingly, the effects on gamma-GCS varied markedly according to the compound: BSO and DEM increased gamma-GCS enzyme activity, although only DEM, but not BSO, resulted in an increase in gamma-GCS(h) mRNA and protein.
Positive_regulation (increase) of gamma-GCS
2) Confidence 0.59 Published 2000 Journal Hepatology Section Abstract Doc Link 10915739 Disease Relevance 0.22 Pain Relevance 0.07
In contrast, APAP and CCl(4) both increased gamma-GCS(h) mRNA and protein; however, there was a marked dose-dependent decrease in gamma-GCS activity.
Positive_regulation (increased) of gamma-GCS
3) Confidence 0.48 Published 2000 Journal Hepatology Section Abstract Doc Link 10915739 Disease Relevance 0.21 Pain Relevance 0.07
Hepatocellular response to chemical stress in CD-1 mice: induction of early genes and gamma-glutamylcysteine synthetase.
Positive_regulation (induction) of gamma-glutamylcysteine synthetase associated with stress
4) Confidence 0.48 Published 2000 Journal Hepatology Section Title Doc Link 10915739 Disease Relevance 0.33 Pain Relevance 0.07
Interestingly, the effects on gamma-GCS varied markedly according to the compound: BSO and DEM increased gamma-GCS enzyme activity, although only DEM, but not BSO, resulted in an increase in gamma-GCS(h) mRNA and protein.
Positive_regulation (increased) of gamma-GCS
5) Confidence 0.39 Published 2000 Journal Hepatology Section Abstract Doc Link 10915739 Disease Relevance 0.28 Pain Relevance 0.07
At these doses maximum effects on gamma-GCS and GSH were observed 2-4 hr after BSO administration; initial gamma-GCS activity and GSH content were restored approximately 16 hr post BSO.
Positive_regulation (restored) of gamma-GCS
6) Confidence 0.39 Published 1984 Journal Biochem. Pharmacol. Section Abstract Doc Link 6148944 Disease Relevance 0.07 Pain Relevance 0.05
BB significantly increased both HO-1 and GCLC protein at this time point, CCl4 increased GCLC protein alone, although FS did not alter either of these proteins.
Positive_regulation (increased) of GCLC
7) Confidence 0.38 Published 2008 Journal Toxicology Section Abstract Doc Link 18078705 Disease Relevance 0.05 Pain Relevance 0.36
Treatment with APAP for 1h caused a significant increase in the levels of haem oxygenase-1 (HO-1; 2.85-fold) and glutamate cysteine ligase (GCLC; 1.62-fold) mRNA.
Positive_regulation (increase) of GCLC associated with glutamate and paracetamol
8) Confidence 0.36 Published 2008 Journal Toxicology Section Abstract Doc Link 18078705 Disease Relevance 0.13 Pain Relevance 0.58
As expected, increased mRNA levels from three NRF2 target genes, HO-1, GSTa2, and GCLC were found in CRIF1 knockdown cells when compared with control cells (Fig. 7C).


Positive_regulation (increased) of GCLC
9) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2898415 Disease Relevance 0 Pain Relevance 0

General Comments

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