INT4141

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Context Info
Confidence 0.31
First Reported 1976
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 19
Total Number 19
Disease Relevance 2.96
Pain Relevance 4.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger1) signal transducer activity (Ptger1)
Anatomy Link Frequency
PGE1 9
blood 2
muscle 1
brain 1
sympathetic 1
Ptger1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 9 100.00 Very High Very High Very High
Cannabinoid 8 100.00 Very High Very High Very High
Cannabinoid receptor 3 100.00 Very High Very High Very High
nociceptor 1 100.00 Very High Very High Very High
fibrosis 2 99.98 Very High Very High Very High
Morphine 15 99.72 Very High Very High Very High
adenocard 2 99.44 Very High Very High Very High
Clonidine 1 98.50 Very High Very High Very High
antagonist 1 98.24 Very High Very High Very High
palliative 6 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Fibrosis 4 99.98 Very High Very High Very High
Priapism 4 99.72 Very High Very High Very High
Increased Venous Pressure Under Development 21 98.60 Very High Very High Very High
Pressure And Volume Under Development 2 96.88 Very High Very High Very High
Hepatocellular Cancer 4 96.56 Very High Very High Very High
Cv Unclassified Under Development 5 94.00 High High
Drug Dependence 2 94.00 High High
Stable Angina Pectoris 2 89.20 High High
Ulcers 1 85.12 High High
Disease 1 84.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interactions of prostaglandin E1 (PGE1) with morphine have been reported in several test systems and an hypothesis has been advanced for a role of prostaglandins in morphine analgesia and physical dependence.
prostaglandin E1 Binding (Interactions) of in PGE1 associated with physical dependence, analgesia and morphine
1) Confidence 0.31 Published 1976 Journal Prostaglandins Section Abstract Doc Link 986671 Disease Relevance 0.09 Pain Relevance 0.76
Interactions of prostaglandin E1 (PGE1) with morphine have been reported in several test systems and an hypothesis has been advanced for a role of prostaglandins in morphine analgesia and physical dependence.
PGE1 Binding (Interactions) of in PGE1 associated with physical dependence, analgesia and morphine
2) Confidence 0.31 Published 1976 Journal Prostaglandins Section Abstract Doc Link 986671 Disease Relevance 0.09 Pain Relevance 0.76
PGE1 has long been recognized as an effective inhibitor of gastric acid secretion when administered intravenously.
PGE1 Binding (recognized) of in PGE1
3) Confidence 0.25 Published 1985 Journal Dig. Dis. Sci. Section Abstract Doc Link 3932041 Disease Relevance 0.22 Pain Relevance 0.11
The effect was maintained during the presence of PGE1 in the organ bath, while rapid tachyphylaxis was observed with the ACh-releasing action of nicotine.
PGE1 Binding (presence) of associated with nicotine
4) Confidence 0.23 Published 1981 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 6115927 Disease Relevance 0 Pain Relevance 0.34
Concentrations of PGE1 associated with 50% reversal of aggregation (C50) were 2.4 +/- 0.3 x 10(-8) M in normal subjects and 6.3 +/- 1.6 x 10(-7) M in patients (p < 0.01).
PGE1 Binding (associated) of in PGE1
5) Confidence 0.20 Published 1995 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 7564342 Disease Relevance 0.16 Pain Relevance 0.21
This finding suggests there is no interaction between Ca ions and PGE1 in the contractile mechanism of the guinea pig heart muscle.
PGE1 Neg (no) Binding (interaction) of in muscle
6) Confidence 0.19 Published 1976 Journal Acta Physiol Acad Sci Hung Section Abstract Doc Link 1031242 Disease Relevance 0 Pain Relevance 0.08
PGE1 also inhibits aggregation of platelets [24] and increases peripheral venous pressure [25] in experimental studies.
PGE1 Binding (aggregation) of in platelets
7) Confidence 0.10 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2358890 Disease Relevance 0.30 Pain Relevance 0
Alpha adrenergic agonists and antagonists as clonidine, guanfacine, yohimbine, phenylephrine and prazosin inhibited the [3H]-QNB binding to rat brain cortex muscarinic acetylcholine receptor (mAChR, M-1 subtype), heart (M-2 subtype) and parotid gland homogenate (M-3 subtype) in a dose-dependent competitive fashion.
M-1 subtype Binding (binding) of in M-1 associated with antagonist, agonist and clonidine
8) Confidence 0.09 Published 1990 Journal Life Sci. Section Abstract Doc Link 1980330 Disease Relevance 0 Pain Relevance 0.30
Forskolin synergistically potentiated adenosine 3',5'-cyclic monophosphate formation by prostaglandin E1 (PGE1) in rat normal hepatocytes freshly prepared by collagenase digestion and rat ascites hepatoma AH66 cells, but dose-dependently inhibited the accumulation by PGE1 in AH66F cells.
PGE1 Binding (formation) of in PGE1 associated with pressure and volume under development, adenocard and hepatocellular cancer
9) Confidence 0.05 Published 1989 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 2545854 Disease Relevance 0.33 Pain Relevance 0.12
Forskolin synergistically potentiated adenosine 3',5'-cyclic monophosphate formation by prostaglandin E1 (PGE1) in rat normal hepatocytes freshly prepared by collagenase digestion and rat ascites hepatoma AH66 cells, but dose-dependently inhibited the accumulation by PGE1 in AH66F cells.
prostaglandin E1 Binding (formation) of in PGE1 associated with pressure and volume under development, adenocard and hepatocellular cancer
10) Confidence 0.05 Published 1989 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 2545854 Disease Relevance 0.33 Pain Relevance 0.12
We report in this retrospective study the results obtained with the first two drugs proposed to reduce the relatively high rates of priapism and fibrosis bound to the papaverine intracavernous injections, i.e. the alpha-blocking agent Moxisylyte (Mox), and prostaglandin E1 (PGE1).
PGE1 Binding (bound) of in PGE1 associated with fibrosis and priapism
11) Confidence 0.05 Published 1996 Journal Int. J. Impot. Res. Section Abstract Doc Link 8858388 Disease Relevance 0.39 Pain Relevance 0.14
We report in this retrospective study the results obtained with the first two drugs proposed to reduce the relatively high rates of priapism and fibrosis bound to the papaverine intracavernous injections, i.e. the alpha-blocking agent Moxisylyte (Mox), and prostaglandin E1 (PGE1).
prostaglandin E1 Binding (bound) of in PGE1 associated with fibrosis and priapism
12) Confidence 0.05 Published 1996 Journal Int. J. Impot. Res. Section Abstract Doc Link 8858388 Disease Relevance 0.39 Pain Relevance 0.14
METHODS: The study, double-blinded, randomised, assessed intravenous infusion of LPC 1.2 g/day in combination with PGE-1, 60 mg/day (LPC group: 37 patients), or PGE-1 only (control group: 38 patients) in a total of 75 patients suffering from CLI.
PGE-1 Binding (combination) of
13) Confidence 0.03 Published 2009 Journal Cardiovasc Drugs Ther Section Body Doc Link 19548076 Disease Relevance 0.09 Pain Relevance 0
METHODS: The study, double-blinded, randomised, assessed intravenous infusion of LPC 1.2 g/day in combination with PGE-1, 60 mg/day (LPC group: 37 patients), or PGE-1 only (control group: 38 patients) in a total of 75 patients suffering from CLI.
PGE-1 Binding (combination) of
14) Confidence 0.03 Published 2009 Journal Cardiovasc Drugs Ther Section Body Doc Link 19548076 Disease Relevance 0.09 Pain Relevance 0
Before the operation, pulmonary blood flow from a ducus arteriosus was maintained by lipo prostaglandin E1 (PGE1).
PGE1 Binding (lipo) of in blood
15) Confidence 0.02 Published 2008 Journal Kyobu Geka Section Abstract Doc Link 18464488 Disease Relevance 0.07 Pain Relevance 0.17
Before the operation, pulmonary blood flow from a ducus arteriosus was maintained by lipo prostaglandin E1 (PGE1).
prostaglandin E1 Binding (lipo) of in blood
16) Confidence 0.02 Published 2008 Journal Kyobu Geka Section Abstract Doc Link 18464488 Disease Relevance 0.07 Pain Relevance 0.17
Previous studies of the structure-activity relationships (SAR) for binding of a series of AC-bicyclic cannabinoid structures to the cannabinoid receptors in rat brain (believed to comprise the CB1 subtype) demonstrated the importance of the A-ring aryl C-3 side chain and phenolic hydroxyl substituents, and elucidated the importance of a C-ring hydroxyalkyl substituent [Melvin et al.
CB1 subtype Binding (binding) of in brain associated with cannabinoid receptor and cannabinoid
17) Confidence 0.02 Published 1995 Journal Drug Des Discov Section Abstract Doc Link 8872458 Disease Relevance 0 Pain Relevance 0.31
Interaction of bradykinin and prostaglandin E1 on cardiac pressor reflex and sympathetic afferents.
prostaglandin E1 Binding (Interaction) of in sympathetic associated with nociceptor and bradykinin
18) Confidence 0.00 Published 1986 Journal Am. J. Physiol. Section Title Doc Link 3706568 Disease Relevance 0 Pain Relevance 0.43
Opiate receptor down-regulation and desensitization were homologous as indicated by the lack of apparent change in muscarinic, alpha 2-adrenergic, and PGE1 receptor binding and also retention, albeit modulation, of the ability of carbachol and norepinephrine to inhibit PGE1-stimulated increases in cyclic AMP levels after 24 hr of etorphine treatment.
PGE1 Binding (binding) of in PGE1 associated with opiate and immobilon
19) Confidence 0.00 Published 1983 Journal Mol. Pharmacol. Section Abstract Doc Link 6314114 Disease Relevance 0.32 Pain Relevance 0.67

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