INT41428

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.32
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.26
Pain Relevance 3.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Vom2r2) signal transducer activity (Vom2r2)
Anatomy Link Frequency
NMU 1
Vom2r2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 9 99.76 Very High Very High Very High
agonist 11 99.74 Very High Very High Very High
antidepressant 7 99.26 Very High Very High Very High
Morphine 11 97.88 Very High Very High Very High
Desipramine 1 93.84 High High
Pain 36 92.32 High High
fortral 2 92.24 High High
Endep 1 92.00 High High
Thermal hyperalgesia 5 91.04 High High
qutenza 1 88.56 High High
Disease Link Frequency Relevance Heat
Nociception 4 99.88 Very High Very High Very High
Death 3 95.04 Very High Very High Very High
Pain 35 92.32 High High
Hyperalgesia 6 91.04 High High
Neuropathic Pain 15 82.52 Quite High
INFLAMMATION 17 79.36 Quite High
Cognitive Disorder 7 77.60 Quite High
Ganglion Cysts 11 41.76 Quite Low
Apoptosis 1 26.36 Quite Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that a number of neuroleptics and antidepressant agents display a potent or moderate affinity to alpha 2-receptor sites.
2-receptor Binding (affinity) of associated with antidepressant
1) Confidence 0.32 Published 1984 Journal Biol. Psychiatry Section Abstract Doc Link 6149771 Disease Relevance 0 Pain Relevance 0.49
In a third experiment, MO (10 micrograms), CLON (10 micrograms), and dexmedetomidine (1 microgram), an alpha 2-agonist with higher affinity for the alpha 2-receptor than CLON, or SAL were injected intrathecally twice daily for 21 days starting 24 h after axotomy.
2-receptor Binding (affinity) of associated with agonist, clonidine and morphine
2) Confidence 0.08 Published 1993 Journal Anesth. Analg. Section Abstract Doc Link 8100405 Disease Relevance 0.15 Pain Relevance 1.97
We found a potent and selective sigma 1 receptor agonist, SA4503 (1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydro-chloride), with high affinity for the sigma 1 receptor subtype (IC50 = 17 nM), but low affinity for the sigma 2 receptor subtype (IC50 = 1800 nM).
2 receptor Binding (affinity) of associated with agonist
3) Confidence 0.02 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8960858 Disease Relevance 0.06 Pain Relevance 0.30
One that stands out is neuromedin U (NMU) which has been shown to have an emerging physiological role in nociception upon binding to the NMU receptor 2 [40].
receptor 2 Binding (binding) of in NMU associated with nociception
4) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949723 Disease Relevance 1.04 Pain Relevance 0.60

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox