INT4144

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Context Info
Confidence 0.68
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 64
Total Number 65
Disease Relevance 39.94
Pain Relevance 6.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SHBG)
Anatomy Link Frequency
blood 5
Plasma 3
liver 3
adrenal glands 2
follicle 2
SHBG (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 36 100.00 Very High Very High Very High
intrathecal 3 99.84 Very High Very High Very High
rheumatoid arthritis 118 99.44 Very High Very High Very High
Opioid 8 99.36 Very High Very High Very High
Dismenorea 30 97.56 Very High Very High Very High
depression 72 96.76 Very High Very High Very High
headache 49 95.76 Very High Very High Very High
carbamazepine 23 95.76 Very High Very High Very High
chronic noncancer pain 1 94.52 High High
Angina 14 94.44 High High
Disease Link Frequency Relevance Heat
Hypertension 452 100.00 Very High Very High Very High
Diabetes Mellitus 298 100.00 Very High Very High Very High
Insulin Resistance 89 100.00 Very High Very High Very High
Thyroid Disease 7 99.88 Very High Very High Very High
Cardiovascular Disease 153 99.64 Very High Very High Very High
Metabolic Syndrome 74 99.64 Very High Very High Very High
Peripheral Arterial Disease 45 99.52 Very High Very High Very High
Rheumatoid Arthritis 137 99.44 Very High Very High Very High
Stress 270 99.36 Very High Very High Very High
Hypotension 42 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During treatment with propylthiouracil and levothyroxine, the plasma concentrations of thyroid hormone, sex hormones and sex hormone-binding globulin normalised and the gynaecomastia disappeared.
Gene_expression (concentrations) of hormone-binding globulin in thyroid
1) Confidence 0.68 Published 2002 Journal Ned Tijdschr Geneeskd Section Abstract Doc Link 11851085 Disease Relevance 0.45 Pain Relevance 0.09
In HP basal testosterone levels were lower than those in NS (1.25 +/- 0.3 vs 7.34 +/- 1.5 ng/ml, p < 0.05) and were restored to normal by hormonal replacement (6.91 +/- 1.3 ng/mL) in HP, both SBP and DBP as well as PR were normal in basal conditions and were not modified by testosterone replacement.
Gene_expression (normal) of SBP
2) Confidence 0.65 Published 1996 Journal J. Endocrinol. Invest. Section Abstract Doc Link 8905472 Disease Relevance 0.14 Pain Relevance 0.40
A reduced double product (SBP X HR) with submaximal exertion results in a decrease in cardiac work and correlates with enhanced exercise capacity and delay in onset of angina during exercise testing.
Gene_expression (product) of SBP associated with angina
3) Confidence 0.65 Published 1986 Journal Am. J. Cardiol. Section Abstract Doc Link 3513517 Disease Relevance 1.04 Pain Relevance 0.09
We therefore recommend that you should consider free testosterone or BAT measurements in all men other than healthy lean young men (whose SHBG levels are presumably normal and whose measured total testosterone concentration is reliable).
Gene_expression (levels) of SHBG
4) Confidence 0.59 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948422 Disease Relevance 0.23 Pain Relevance 0
Production of SHBG is inhibited by insulin; therefore, low levels of SHBG are associated with elevated insulin levels.
Gene_expression (Production) of SHBG
5) Confidence 0.58 Published 2008 Journal Trends Cardiovasc Med Section Body Doc Link PMC2577131 Disease Relevance 1.40 Pain Relevance 0
Sex-hormone-binding globulin (SHBG) is a glycoprotein produced by the liver which binds circulating estrogens and testosterone.
Gene_expression (produced) of SHBG in liver
6) Confidence 0.58 Published 2008 Journal Trends Cardiovasc Med Section Body Doc Link PMC2577131 Disease Relevance 1.38 Pain Relevance 0
Sex-hormone-binding globulin (SHBG) is a glycoprotein produced by the liver which binds circulating estrogens and testosterone.
Gene_expression (produced) of Sex-hormone-binding globulin in liver
7) Confidence 0.58 Published 2008 Journal Trends Cardiovasc Med Section Body Doc Link PMC2577131 Disease Relevance 1.40 Pain Relevance 0
Night SBP was higher only in patients with antihypertensive treatment.
Gene_expression (higher) of SBP
8) Confidence 0.58 Published 2004 Journal J Hum Hypertens Section Abstract Doc Link 14973514 Disease Relevance 0.83 Pain Relevance 0.06
Testosterone, SHBG, DHEA and DHEAS (for suspected cases with PCO syndrome)
Gene_expression (Testosterone) of SHBG associated with syndrome and polycystic ovary syndrome
9) Confidence 0.58 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2844387 Disease Relevance 1.29 Pain Relevance 0.08
We recently reported also that sex hormone-binding globulin
   (SHBG) is an important determinant of dyslipidemia and cardiometabolic disorders, especially in
   women, independent of abdominal obesity and insulin resistance 10 which warrants the investigation also of the association between SHBG and
   adiponectin levels.
Gene_expression (levels) of SHBG associated with metabolic syndrome and insulin resistance
10) Confidence 0.56 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.07 Pain Relevance 0.11
Although in this study, soy supplementation for one year did not produce any estrogenic effects as assessed by circulating sex hormone levels, it did decrease SHBG concentrations Decreases in SHBG result in increases in the availability of circulating estrogens [65].
Gene_expression (levels) of sex hormone
11) Confidence 0.56 Published 2005 Journal Nutr J Section Body Doc Link PMC554088 Disease Relevance 0.22 Pain Relevance 0
If pregnancy is not desired, oral contraceptive pills provide several benefits, including lowering ovarian androgen production, maintaining monthly menses, and raising sex hormone binding globulin (SHBG), which lowers free testosterone and mitigates some of the hyperandrogenism with lower doses of glucocorticoid therapy.
Gene_expression (raising) of SHBG associated with hyperandrogenism
12) Confidence 0.55 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2896848 Disease Relevance 0.49 Pain Relevance 0.10
Age-related decreases in insulin-like growth factor 1 (IGF-1) and increases in insulin-like growth factor binding protein 2 (IGFBP-2) levels may also impair bone formation directly or via an increase in serum SHBG levels (Amin et al 2004, 2007).
Gene_expression (levels) of SHBG
13) Confidence 0.55 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682396 Disease Relevance 0.53 Pain Relevance 0.04
Loss of significant weight has been reported to result in spontaneous resumption of ovulation (Crosignani et al 2003), improvement in fertility (Norman et al 2004), increased SHBG, and reduced basal level of insulin (Huber-Buchholz et al 1999; Tolino et al 2005).
Gene_expression (level) of SHBG
14) Confidence 0.55 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994046 Disease Relevance 1.59 Pain Relevance 0.04
Still, some of them increase the hepatogen production of SHBG–reducing, free testosterone levels.
Gene_expression (production) of SHBG
15) Confidence 0.51 Published 2010 Journal International Journal of Trichology Section Body Doc Link PMC3002408 Disease Relevance 1.06 Pain Relevance 0.04
At the same time insulin decreases the production of SHBG in the liver, leading to increased levels of free active testosterone.
Gene_expression (production) of SHBG in liver
16) Confidence 0.51 Published 2010 Journal International Journal of Trichology Section Body Doc Link PMC3002408 Disease Relevance 1.26 Pain Relevance 0.03
As a result, studies have used low SHBG levels as a marker of insulin resistance in both cardiovascular disease (Sherif et al. 1998) and in preeclampsia (Carlsen et al. 2005, Spencer et al. 2005, Wolf et al. 2002).
Gene_expression (resistance) of SHBG associated with cardiovascular disease, insulin resistance and pre-eclampsia
17) Confidence 0.51 Published 2008 Journal Trends Cardiovasc Med Section Body Doc Link PMC2577131 Disease Relevance 1.41 Pain Relevance 0
If pregnancy is not desired, oral contraceptive pills provide several benefits, including lowering ovarian androgen production, maintaining monthly menses, and raising sex hormone binding globulin (SHBG), which lowers free testosterone and mitigates some of the hyperandrogenism with lower doses of glucocorticoid therapy.
Gene_expression (raising) of hormone binding globulin associated with hyperandrogenism
18) Confidence 0.48 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2896848 Disease Relevance 0.49 Pain Relevance 0.10
Hepatic enzyme inducing AEDs can alter the synthesis and metabolism of sex steroids, serum levels of sex hormone binding globulin (SHBG) as well as central feedback mechanisms [61,62,66].
Gene_expression (synthesis) of SHBG
19) Confidence 0.48 Published 2006 Journal Nutr Metab (Lond) Section Body Doc Link PMC1586194 Disease Relevance 0.19 Pain Relevance 0.15
In both Met-anov and Met-ov groups, serum levels of LH, T, A, DHEAS, SHBG, fasting insulin, and AMH as well as the Ferriman-Gallwey score, FAI, GIR and HOMA, were significantly (p < 0.05) better than those in PCOS controls and significantly (p < 0.05) worse than those in non-PCOS controls (Table 1).
Gene_expression (levels) of SHBG associated with polycystic ovary syndrome
20) Confidence 0.47 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2912910 Disease Relevance 0.26 Pain Relevance 0

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