INT41460

Context Info Confidence 0.10 First Reported 1984 Last Reported 1984 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.10 Pain Relevance 0.36

cytoplasm (Crh, Pomc) extracellular space (Crh, Pomc) extracellular region (Crh, Pomc) cell-cell signaling (Pomc) response to stress (Crh) generation of precursor metabolites and energy (Pomc)

Anatomy Link Frequency pituitary 1 Crh (Rattus norvegicus) Pomc (Rattus norvegicus)

Pain Link Frequency Relevance Heat Thalamus 5 99.70 Neurotransmitter 1 98.60 analgesia 1 95.36 Pain 1 25.00

Disease Link Frequency Relevance Heat Nociception 1 96.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

The presence of CRF-immunopositive structures in the thalamus suggests that CRF not only functions as a hypophysiotropic hormone regulating the release of ACTH and beta-endorphin from the pituitary, but also as a neurotransmitter or neuromodulator, playing an important role in nociception and analgesia.

CRF Regulation (regulating) of beta-endorphin in pituitary associated with nociception, neurotransmitter, thalamus and analgesia

1) Confidence 0.10 Published 1984 Journal Brain Res. Section Abstract Doc Link 6151862 Disease Relevance 0.10 Pain Relevance 0.36

General Comments

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