INT41461

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Context Info
Confidence 0.10
First Reported 1984
Last Reported 1984
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Crh, Pomc) extracellular space (Crh, Pomc) extracellular region (Crh, Pomc)
cell-cell signaling (Pomc) response to stress (Crh) generation of precursor metabolites and energy (Pomc)
Anatomy Link Frequency
pituitary 2
Crh (Rattus norvegicus)
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thalamus 5 99.70 Very High Very High Very High
Neurotransmitter 1 98.60 Very High Very High Very High
analgesia 1 95.36 Very High Very High Very High
Pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 1 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presence of CRF-immunopositive structures in the thalamus suggests that CRF not only functions as a hypophysiotropic hormone regulating the release of ACTH and beta-endorphin from the pituitary, but also as a neurotransmitter or neuromodulator, playing an important role in nociception and analgesia.
CRF Regulation (regulating) of Localization (release) of beta-endorphin in pituitary associated with nociception, neurotransmitter, thalamus and analgesia
1) Confidence 0.10 Published 1984 Journal Brain Res. Section Abstract Doc Link 6151862 Disease Relevance 0.10 Pain Relevance 0.36

General Comments

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