INT4147

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Context Info
Confidence 0.49
First Reported 1976
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 3.94
Pain Relevance 2.88

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signal transduction (LHB) small molecule metabolic process (LHB) extracellular region (LHB)
cellular nitrogen compound metabolic process (LHB) cell-cell signaling (LHB)
Anatomy Link Frequency
follicle 4
plasma 2
hypothalamus 1
LHB (Homo sapiens)
Pain Link Frequency Relevance Heat
Cluster headache 6 99.84 Very High Very High Very High
Endogenous opioid 2 98.82 Very High Very High Very High
narcan 6 98.42 Very High Very High Very High
Dismenorea 12 95.56 Very High Very High Very High
opiate 7 93.12 High High
Pain 5 89.00 High High
antagonist 5 86.08 High High
headache 1 85.76 High High
Morphine 4 78.36 Quite High
Dopamine 3 77.32 Quite High
Disease Link Frequency Relevance Heat
Cluster Headache 6 99.84 Very High Very High Very High
Cancer 5 98.80 Very High Very High Very High
Pituitary Cancer 3 98.56 Very High Very High Very High
Insulin Resistance 3 97.52 Very High Very High Very High
Reprotox - General 1 14 95.56 Very High Very High Very High
Dysmenorrhea 8 95.48 Very High Very High Very High
Syndrome 2 94.40 High High
Recurrence 1 94.24 High High
Acth-secreting Pituitary Adenoma 3 90.48 High High
Pain 3 89.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma levels of estrogen, progesterone, luteinizing hormone (LH), testosterone, and beta-endorphin were determined at each experimental session.
Spec (determined) Gene_expression (levels) of luteinizing hormone in Plasma
1) Confidence 0.49 Published 1997 Journal Psychosom Med Section Abstract Doc Link 9316184 Disease Relevance 0.24 Pain Relevance 0.24
Immunohistochemistry revealed the presence of adrenocorticotropin (ACTH) in all four biopsies, alpha-subunit of glycoprotein hormones, and, to a lesser extent, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in the third and fourth tumor resection specimens.
Gene_expression (presence) of luteinizing hormone in follicle associated with cancer
2) Confidence 0.21 Published 1991 Journal Hum. Pathol. Section Abstract Doc Link 1649119 Disease Relevance 0.98 Pain Relevance 0.09
Both the LH and the FSH profiles are thought secondary to a fundamental increase in GnRH from the hypothalamus which ultimately favors the gene expression of LHb over FSHb (Azziz et al 2006).
Gene_expression (expression) of LHb in hypothalamus
3) Confidence 0.08 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504056 Disease Relevance 1.14 Pain Relevance 0
Following the drug administrations, progesterone, estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin plasma levels were measured.
Gene_expression (levels) of luteinizing hormone in plasma
4) Confidence 0.07 Published 1999 Journal Gynecol. Endocrinol. Section Abstract Doc Link 10599553 Disease Relevance 0.35 Pain Relevance 0.35
Total, free and carrier protein-bound testosterone levels were significantly diminished only in chronic CH, where luteinizing hormone (LH) peak values after intravenous administration of LHRH were also decreased.
Gene_expression (administration) of luteinizing hormone associated with cluster headache
5) Confidence 0.03 Published 1989 Journal Cephalalgia Section Abstract Doc Link 2663174 Disease Relevance 0.44 Pain Relevance 0.53
Levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone-estradiol binding globulin (TeBG), estrogen, and progesterone were measured in 15 women with premenstrual tension (PMT) syndrome and compared with a control group of 17 women.
Gene_expression (Levels) of luteinizing hormone in follicle associated with syndrome and dismenorea
6) Confidence 0.02 Published 1976 Journal J. Steroid Biochem. Section Abstract Doc Link 987514 Disease Relevance 0.55 Pain Relevance 0.46
The levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), 17 beta-estradiol and progesterone were also measured.
Gene_expression (levels) of luteinizing hormone in follicle
7) Confidence 0.01 Published 1997 Journal Gynecol. Endocrinol. Section Abstract Doc Link 9174847 Disease Relevance 0 Pain Relevance 0.18
All samples were assayed for luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin.
Gene_expression (assayed) of luteinizing hormone in follicle
8) Confidence 0.01 Published 1993 Journal Hum. Reprod. Section Abstract Doc Link 8501180 Disease Relevance 0.14 Pain Relevance 0.48
Do endogenous opioid peptides mediate the effects of photoperiod on release of luteinizing hormone and prolactin in ovariectomized ewes?
Gene_expression (hormone) of luteinizing hormone associated with narcan and endogenous opioid
9) Confidence 0.01 Published 1985 Journal Biol. Reprod. Section Title Doc Link 4005347 Disease Relevance 0.09 Pain Relevance 0.55

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