INT41470

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Context Info
Confidence 0.85
First Reported 1984
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) response to stress (Oxt)
cytoplasm (Oxt)
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 3 99.40 Very High Very High Very High
opiate 3 96.98 Very High Very High Very High
Dynorphin 5 96.38 Very High Very High Very High
antagonist 2 91.52 High High
narcan 7 90.64 High High
Locus ceruleus 1 86.80 High High
Opioid 2 75.00 Quite High
withdrawal 2 74.64 Quite High
tail-flick 2 72.56 Quite High
Endogenous opioid 1 55.04 Quite High
Disease Link Frequency Relevance Heat
Stress 2 92.84 High High
Sleep Disorders 1 78.48 Quite High
Weight Gain 1 63.60 Quite High
Hypotension 1 28.24 Quite Low
Cardiovascular Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here the existence of an opposite psycho-physiological pattern associated with relaxation and growth and which is activated by certain types of non-noxious stimuli and integrated by oxytocin is proposed.
Protein_catabolism (integrated) of oxytocin
1) Confidence 0.85 Published 1997 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 9401603 Disease Relevance 0.31 Pain Relevance 0.14
The opiate inactive fragment [des-Tyr1]dynorphin (1-17) did not change the evoked VP and OT release, indicating that the dynorphin effect was mediated by opiate receptors. beta-Endorphin (10(-6) M and 10(-7) M) did not alter the evoked VP and OT secretion. 10(-6) M [Leu]enkephalin induced a stimulation of the evoked OT, but not VP release; 10(-7) M [Leu]enkephalin had no effect, neither on VP nor on OT release.
Protein_catabolism (evoked) of OT associated with dynorphin, enkephalin and opiate
2) Confidence 0.51 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6152015 Disease Relevance 0 Pain Relevance 1.12

General Comments

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