INT41474

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Context Info
Confidence 0.75
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 1.56
Pain Relevance 2.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ADRB2) plasma membrane (ADRB2) nucleus (ADRB2)
lysosome (ADRB2) cytoplasm (ADRB2) signal transducer activity (ADRB2)
Anatomy Link Frequency
myometrium 1
ADRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 46 100.00 Very High Very High Very High
agonist 165 99.00 Very High Very High Very High
Morphine 2 94.48 High High
opioid receptor 1 93.84 High High
aspirin 3 87.44 High High
Clonidine 3 85.24 High High
Calcium channel 8 83.88 Quite High
Opioid 2 82.04 Quite High
noradrenaline 7 79.84 Quite High
Dismenorea 4 62.44 Quite High
Disease Link Frequency Relevance Heat
Hypertension 3 99.52 Very High Very High Very High
Bordatella Infection 1 97.28 Very High Very High Very High
Nicotine Addiction 15 96.44 Very High Very High Very High
Obesity 12 96.00 Very High Very High Very High
Coronary Artery Disease 19 92.68 High High
Myocardial Infarction 16 90.68 High High
Asthma 72 80.00 Quite High
Stress 12 76.24 Quite High
Pre-term Labor 8 70.32 Quite High
Hyperplasia 1 67.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this cell line, endogenous beta2-adrenergic receptors (beta2-ARs) are coexpressed with the exogenous delta-ORs.
Gene_expression (coexpressed) of beta2-AR
1) Confidence 0.75 Published 1999 Journal Cell Prolif. Section Abstract Doc Link 10614711 Disease Relevance 0.07 Pain Relevance 0.48
The ADRB3 is predominant over the ADRB2 and its expression is increased during pregnancy
Gene_expression (over) of ADRB2
2) Confidence 0.67 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0 Pain Relevance 0.25
Binding competition studies, transcripts and protein analysis were then performed to determine whether any changes in the number of ADRB2 and ADRB3 binding sites and in the transcript and protein expression might explain the observed change in the contractile response between non-pregnant and pregnant myometrium to ADRB2 and ADRB3 agonists.
Gene_expression (expression) of ADRB2 in myometrium associated with agonist
3) Confidence 0.67 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0 Pain Relevance 0.07
The ADRB3 is predominant over the ADRB2 and its expression is increased during pregnancy
Gene_expression (predominant) of ADRB2
4) Confidence 0.67 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0 Pain Relevance 0.25
The ADRB3 shares 40 to 50% amino acid sequence identity with ADRB1 and ADRB2.
Gene_expression (shares) of ADRB2
5) Confidence 0.67 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0.45 Pain Relevance 0.23
2-Agonist pharmacogenomic studies have focused on the effect of ADRB2 variants on the response or adverse outcomes of ?
Gene_expression (variants) of ADRB2 associated with agonist
6) Confidence 0.66 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2892049 Disease Relevance 0.25 Pain Relevance 0.27
Isoprenaline (beta 1- and beta 2-adrenoreceptor agonist) and procaterol (beta 2-adrenoreceptor agonist) increased the release, propranolol (beta 1- and beta 2-adrenoreceptor antagonist) reduced it, and prenalterol (beta 1-adrenoreceptor agonist) and atenolol (beta 1-adrenoreceptor antagonist) had no effect.
Gene_expression (antagonist) of beta 2-adrenoreceptor associated with antagonist and agonist
7) Confidence 0.53 Published 1984 Journal J Auton Pharmacol Section Abstract Doc Link 6152266 Disease Relevance 0 Pain Relevance 0.90
They were treated mainly with beta-adrenergic receptor blockers or angiotensin-converting enzyme (ACE)-inhibitors, only two patients were on anti-arrhythmic therapy.
Gene_expression (treated) of beta-adrenergic receptor
8) Confidence 0.44 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2958976 Disease Relevance 0.69 Pain Relevance 0.09
The presence of transfected B2AR prevents the oxidation of Asc under both conditions.
Gene_expression (transfected) of B2AR
9) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001466 Disease Relevance 0 Pain Relevance 0
In addition, SCH-202676 inhibited antagonist binding to the beta2-adrenergic receptor expressed in Escherichia coli, a system devoid of classical heterotrimeric G proteins.
Gene_expression (expressed) of beta2-adrenergic associated with antagonist
10) Confidence 0.01 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11125021 Disease Relevance 0.10 Pain Relevance 0.41

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