INT41475

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Context Info
Confidence 0.49
First Reported 1984
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.18
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ADRB2) plasma membrane (ADRB2) nucleus (ADRB2)
lysosome (ADRB2) cytoplasm (ADRB2) signal transducer activity (ADRB2)
ADRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 6 99.96 Very High Very High Very High
antagonist 5 99.96 Very High Very High Very High
Neurotransmitter 1 90.84 High High
Clonidine 3 87.16 High High
noradrenaline 7 81.76 Quite High
Serotonin 1 72.36 Quite High
opiate 1 71.32 Quite High
Opioid 1 70.84 Quite High
Disease Link Frequency Relevance Heat
Affective Disorder 2 96.64 Very High Very High Very High
Squamous Cell Carcinoma 1 83.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lithium suppresses signaling and induces rapid sequestration of beta2-adrenergic receptors.
Positive_regulation (induces) of Localization (sequestration) of beta2-adrenergic
1) Confidence 0.49 Published 2001 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 11594766 Disease Relevance 0.18 Pain Relevance 0.22
Isoprenaline (beta 1- and beta 2-adrenoreceptor agonist) and procaterol (beta 2-adrenoreceptor agonist) increased the release, propranolol (beta 1- and beta 2-adrenoreceptor antagonist) reduced it, and prenalterol (beta 1-adrenoreceptor agonist) and atenolol (beta 1-adrenoreceptor antagonist) had no effect.
Positive_regulation (increased) of Localization (release) of beta 2-adrenoreceptor associated with antagonist and agonist
2) Confidence 0.37 Published 1984 Journal J Auton Pharmacol Section Abstract Doc Link 6152266 Disease Relevance 0 Pain Relevance 0.90

General Comments

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