INT4148

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Context Info
Confidence 0.77
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 2.71
Pain Relevance 4.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (HRH1) plasma membrane (HRH1) nucleus (HRH1)
cytoplasm (HRH1) signal transducer activity (HRH1)
Anatomy Link Frequency
trachea 1
embryonic kidney 1
HRH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 37 100.00 Very High Very High Very High
agonist 26 100.00 Very High Very High Very High
Analgesic 2 100.00 Very High Very High Very High
interstitial cystitis 3 99.84 Very High Very High Very High
Morphine 3 99.84 Very High Very High Very High
qutenza 15 99.64 Very High Very High Very High
tolerance 5 99.48 Very High Very High Very High
Mexiletine 6 99.18 Very High Very High Very High
Serotonin 36 98.98 Very High Very High Very High
Physical dependence 5 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 15 99.84 Very High Very High Very High
Interstitial Cystitis 3 99.84 Very High Very High Very High
Pruritus 7 99.16 Very High Very High Very High
Drug Dependence 6 98.92 Very High Very High Very High
INFLAMMATION 35 97.92 Very High Very High Very High
Pressure And Volume Under Development 5 81.12 Quite High
Overactive Bladder 2 77.92 Quite High
Serotonin Syndrome 5 55.60 Quite High
Depression 48 48.00 Quite Low
Ganglion Cysts 1 44.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, pre-therapeutic evaluation of histamine receptor expression in IC patients may help to optimize therapy by using a patient-specific cocktail of subtype-specific histamine receptor antagonists.
Gene_expression (expression) of histamine receptor associated with antagonist and interstitial cystitis
1) Confidence 0.77 Published 2006 Journal World J Urol Section Abstract Doc Link 16609864 Disease Relevance 0.46 Pain Relevance 0.36
To examine if this is also true for mexiletine, we have systematically measured mexiletine sensitivity of the Na channel isoforms, rH1, (mu)1, and rBII, which were transiently expressed in human embryonic kidney (HEK) 293 cells.
Gene_expression (expressed) of rH1 in embryonic kidney associated with mexiletine
2) Confidence 0.36 Published 2002 Journal FEBS Lett. Section Abstract Doc Link 11904157 Disease Relevance 0 Pain Relevance 0.49
The mechanism of action of most TCAs is noradrenaline and serotonin reuptake inhibition.38 They also antagonize post- synaptic histamine H1, ?
Gene_expression (synaptic) of histamine H1 associated with noradrenaline, serotonin and tricyclic antidepressant
3) Confidence 0.16 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 0.13 Pain Relevance 0.72
In previous work with the mouse implantation model, we found that histamine receptor antagonists could be used to reduce biomaterial-mediated acute inflammatory responses [Error!
Gene_expression (antagonists) of histamine receptor associated with inflammatory response and antagonist
4) Confidence 0.12 Published 2007 Journal J Transl Med Section Body Doc Link PMC1929055 Disease Relevance 0.25 Pain Relevance 0.25
Influence of beta-adrenergic antagonists, H1-receptor blockers, analgesics, diuretics, and quinolone antibiotics on the cellular accumulation of the anticancer drug, daunorubicin: P-glycoprotein modulation.
Gene_expression (modulation) of H1-receptor associated with analgesic and antagonist
5) Confidence 0.12 Published 2001 Journal Anticancer Res. Section Title Doc Link 11396174 Disease Relevance 0 Pain Relevance 0.25
On the other hand, studies of the histamine H1 receptor and ?
Gene_expression (studies) of histamine H1 receptor
6) Confidence 0.10 Published 2007 Journal BMC Bioinformatics Section Body Doc Link PMC1904246 Disease Relevance 0 Pain Relevance 0
Existing data on the expression of H(4) histamine receptor in the CNS are conflicting and inconclusive.
Gene_expression (expression) of histamine receptor
7) Confidence 0.04 Published 2009 Journal Brain Res. Section Abstract Doc Link 19046950 Disease Relevance 0 Pain Relevance 0.34
The effects of L-histidine and of specific histamine receptor agonists, on the expression of morphine tolerance and physical dependence in mice.
Gene_expression (expression) of histamine receptor associated with physical dependence, tolerance, agonist and morphine
8) Confidence 0.02 Published 1976 Journal Agents Actions Section Title Doc Link 987696 Disease Relevance 0.35 Pain Relevance 0.82
To address this question, we examined the effects of neonatal capsaicin treatment on allergic reactions and H1 histamine receptor-expressing sensory neurones in mice.
Gene_expression (expressing) of histamine receptor associated with qutenza and hypersensitivity
9) Confidence 0.02 Published 2008 Journal Acta Derm. Venereol. Section Abstract Doc Link 18779880 Disease Relevance 0.75 Pain Relevance 0.39
Different roles of capsaicin-sensitive and H1 histamine receptor-expressing sensory neurones in itch of mosquito allergy in mice.
Gene_expression (expressing) of histamine receptor associated with qutenza, hypersensitivity and pruritus
10) Confidence 0.02 Published 2008 Journal Acta Derm. Venereol. Section Title Doc Link 18779880 Disease Relevance 0.78 Pain Relevance 0.55
In the guinea pig trachea, 100 nM PGE(2) and 1 microM PGE(2) ethanolamide produced contractions of 51.8 +/- 10.6 and 38.9 +/- 5.6% (of the histamine E(max)), respectively.
Gene_expression (produced) of histamine E in trachea
11) Confidence 0.01 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12023517 Disease Relevance 0 Pain Relevance 0.05

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