INT41494

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Context Info
Confidence 0.58
First Reported 1980
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 11.73
Pain Relevance 19.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tacr1) response to stress (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
neurons 10
spinal cord 4
brain 4
dorsal horn 4
joints 4
Tacr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 539 100.00 Very High Very High Very High
dorsal root ganglion 388 100.00 Very High Very High Very High
Calcitonin gene-related peptide 106 100.00 Very High Very High Very High
antagonist 64 100.00 Very High Very High Very High
Spinal cord 49 100.00 Very High Very High Very High
Dorsal horn 34 100.00 Very High Very High Very High
Pain 98 99.98 Very High Very High Very High
electroacupuncture 8 99.98 Very High Very High Very High
analgesia 6 99.86 Very High Very High Very High
Morphine 5 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 391 100.00 Very High Very High Very High
Stress 28 100.00 Very High Very High Very High
Pain 108 99.98 Very High Very High Very High
Nociception 78 99.82 Very High Very High Very High
INFLAMMATION 223 99.00 Very High Very High Very High
Nervous System Injury 53 97.68 Very High Very High Very High
Depression 9 95.92 Very High Very High Very High
Hyperalgesia 48 94.20 High High
Inflammatory Pain 14 92.52 High High
Pressure And Volume Under Development 40 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the basis of loss of lamina I NK-1R staining, lumbar intrathecal SSP-sap was seven times more potent than SP-sap and produced no loss of NK-1R expressing neurons in deeper laminae (III-VI or X).
Neg (no) Negative_regulation (loss) of Gene_expression (expressing) of NK-1R in neurons associated with intrathecal
1) Confidence 0.58 Published 2007 Journal Neuroscience Section Abstract Doc Link 17418497 Disease Relevance 0.23 Pain Relevance 0.57
Electroacupuncture suppresses spinal expression of neurokinin-1 receptors induced by persistent inflammation in rats.
Negative_regulation (suppresses) of Gene_expression (expression) of neurokinin-1 in spinal associated with inflammation and electroacupuncture
2) Confidence 0.58 Published 2005 Journal Neurosci. Lett. Section Title Doc Link 15908113 Disease Relevance 0.78 Pain Relevance 1.13
The greatest loss in co-expression of nAChR subunits with NK1-r was observed with alpha3, alpha5, beta2 and beta4 subunits.
Negative_regulation (loss) of Gene_expression (co-expression) of NK1-r
3) Confidence 0.57 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18037142 Disease Relevance 0.08 Pain Relevance 0.77
In addition, after chronic administration baclofen was no longer capable of inducing analgesia or of inhibiting the increased expression of NK-1R mRNA and CGP 44532 was still fully effective in both regards.
Negative_regulation (inhibiting) of Gene_expression (expression) of NK-1R mRNA associated with analgesia
4) Confidence 0.55 Published 1998 Journal Life Sci. Section Abstract Doc Link 9585130 Disease Relevance 0.40 Pain Relevance 1.05
Hippocampal neurokinin-1 receptor and brain-derived neurotrophic factor gene expression is decreased in rat models of pain and stress.
Negative_regulation (decreased) of Gene_expression (expression) of neurokinin-1 in brain associated with stress and pain
5) Confidence 0.49 Published 2005 Journal Neuroscience Section Title Doc Link 15964488 Disease Relevance 0.90 Pain Relevance 0.78
Results showed that either stress or pain down-regulates expression of both NK-1 receptor and BDNF genes in the hippocampus.
Negative_regulation (down-regulates) of Gene_expression (expression) of NK-1 receptor in hippocampus associated with stress, pain and hippocampus
6) Confidence 0.41 Published 2005 Journal Neuroscience Section Abstract Doc Link 15964488 Disease Relevance 1.31 Pain Relevance 0.84
Data indicate that a possible mechanism for this effect is a GABA(B) receptor-induced blockade of neurokinin-1 (NK-1) receptor gene expression in the spinal cord.
Negative_regulation (blockade) of Gene_expression (expression) of neurokinin-1 in spinal cord associated with gaba and spinal cord
7) Confidence 0.40 Published 1998 Journal Life Sci. Section Abstract Doc Link 9585130 Disease Relevance 0.40 Pain Relevance 0.82
Three weeks after intrathecal administration of SSP-saporin, NK1R immunoreactivity in lamina I of the spinal cord was significantly reduced, but cystometric parameters in awake rats were not altered.
Negative_regulation (reduced) of Gene_expression (immunoreactivity) of NK1R in lamina associated with spinal cord and intrathecal
8) Confidence 0.40 Published 2005 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 15692058 Disease Relevance 0.30 Pain Relevance 0.75
CONCLUSION: EA-Futu (LI 18) can significantly suppress pain reaction of neck incision in the rat, which is closely associated with its effects in downregulating the expression of SP, NK-1 R, COX-1 and upregulating that of 5-HT 1 AR and 5-HT 2 AR in the spinal dorsal horn.


Negative_regulation (downregulating) of Gene_expression (expression) of NK-1 R in spinal
9) Confidence 0.37 Published 2010 Journal Zhen Ci Yan Jiu Section Body Doc Link 20626139 Disease Relevance 0 Pain Relevance 0
Neither the NMDA receptor blocker MK-801 nor the GABA(B) agonist baclofen decreased NK1R internalization produced by 1 microM capsaicin applied to the slices, but they inhibited the internalization produced by 0.3 microM capsaicin applied to the slices or 1 microM capsaicin applied to the root.
Neg (Neither) Negative_regulation (decreased) of Gene_expression (produced) of NK1R associated with gaba, qutenza, nmda receptor and agonist
10) Confidence 0.37 Published 2003 Journal Neuroscience Section Abstract Doc Link 14568027 Disease Relevance 0 Pain Relevance 1.44
Effects of analgesic or antidepressant drugs on pain- or stress-evoked hippocampal and spinal neurokinin-1 receptor and brain-derived neurotrophic factor gene expression in the rat.
Negative_regulation (stress-evoked) of Gene_expression (expression) of neurokinin-1 receptor in brain associated with stress, pain, antidepressant and analgesic
11) Confidence 0.36 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 16956981 Disease Relevance 1.28 Pain Relevance 1.60
In both instances, baclofen reduced Fos expression not only in neurons that express the neurokinin-1 receptor, but also in neurons that do not.
Negative_regulation (reduced) of Gene_expression (express) of neurokinin-1 receptor in neurons
12) Confidence 0.30 Published 2001 Journal Neuroscience Section Abstract Doc Link 11274791 Disease Relevance 0.16 Pain Relevance 0.88
As shown in Figs 3A and 3B, the time-dependent (10–360 min) exposure of cultured DRG neurons to SP (200 pg/dish) resulted in a significant decrease of the neurokinin-1 receptor expression in the membrane fractions (104 ± 15%, 74 ± 4% and 42 ± 5%, 14 ± 1% in Figs 3A and 3B, respectively, compared with the control at 10 min).
Negative_regulation (decrease) of Gene_expression (expression) of neurokinin-1 in neurons associated with dorsal root ganglion and substance p
13) Confidence 0.29 Published 2007 Journal Mol Pain Section Body Doc Link PMC2235838 Disease Relevance 0.39 Pain Relevance 0.60
Interestingly, we observed a gradual decrease of the neurokinin-1 receptor expression in the membrane fraction from the untreated DRG neurons (the control).
Negative_regulation (decrease) of Gene_expression (expression) of neurokinin-1 in neurons associated with dorsal root ganglion
14) Confidence 0.29 Published 2007 Journal Mol Pain Section Body Doc Link PMC2235838 Disease Relevance 0.40 Pain Relevance 0.58
Interestingly, a significant reduction in the percentage of neurons expressing neurokinin-1 receptor on their membranes was observed after the time-dependent stimulation of 200 pg/dish SP (85 ± 4%, 71 ± 7% and 56 ± 5%, 32 ± 2% in Figs 2Av–viii, respectively) in comparison to their respective controls (p > 0.05, p > 0.05 and p < 0.05, p < 0.001, respectively).
Negative_regulation (reduction) of Gene_expression (expressing) of neurokinin-1 in neurons associated with substance p
15) Confidence 0.29 Published 2007 Journal Mol Pain Section Body Doc Link PMC2235838 Disease Relevance 0.25 Pain Relevance 0.26
The capsaicin-induced body movement was inhibited by a tachykinin NK1-receptor antagonist RP-67580 with an ID50 value of 3.5 mg/kg, s.c.
Negative_regulation (inhibited) of Gene_expression (antagonist) of NK1-receptor in body associated with qutenza and antagonist
16) Confidence 0.26 Published 1999 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10440532 Disease Relevance 0.22 Pain Relevance 1.20
Down-regulation of NK-1 receptor gene expression occurred as early as 24 h and persisted through the 21st day post-CFA administration.
Negative_regulation (regulation) of Gene_expression (expression) of NK-1 receptor gene
17) Confidence 0.24 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.22 Pain Relevance 0.30
Nociception-induced neurokinin-1 receptor messenger RNA expression in the dorsal horn was blocked by morphine, but was not affected by naltrexone.
Negative_regulation (blocked) of Gene_expression (expression) of neurokinin-1 receptor in dorsal horn associated with nociception, dorsal horn and morphine
18) Confidence 0.23 Published 1995 Journal Neuroscience Section Abstract Doc Link 7536308 Disease Relevance 0.51 Pain Relevance 1.03
Real-time PCR was used to evaluate gene expression of NK-1R, NR-1, and NR-2A.
Negative_regulation (evaluate) of Gene_expression (expression) of NK-1R
19) Confidence 0.22 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15922485 Disease Relevance 0.50 Pain Relevance 0.33
Addition of indomethacin to co-cultures inhibited the effect of FLS cells from acutely inflamed joints on neurokinin 1 receptor expression, suggesting an important role for prostaglandins.
Negative_regulation (inhibited) of Gene_expression (expression) of neurokinin 1 receptor in joints
20) Confidence 0.18 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860064 Disease Relevance 1.00 Pain Relevance 0.75

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